W4-I.1 Beach RH, McCarl BA, Ohrel SB, DeAngelo BJ, Ross MT; rbeach@rti.orgRTI InternationalMODELING U.S. AGRICULTURAL RESPONSE UNDER CLIMATECHANGEClimate change will affect future agricultural production through changes in atmosphericcarbon dioxide levels, average and extreme temperatures, precipitation patternsand intensity, and the frequency and severity of extreme events such as flooding,drought, hail, and hurricanes. Assessing the impact of the climatic changes oncrop yield, output levels and commodity prices, however, also depends on behavioraland adaptive responses in the agricultural sector. In this study, we estimate potentiallong-term implications of climate change on U.S. landowner decisions regarding landuse, crop mix, and production practices, combining a crop process model (EPIC) tocapture the changes in the physical system with a <strong>for</strong>ward-looking dynamic economicmodel of the U.S. <strong>for</strong>estry and agricultural sector (FASOM). Climate-induced changesin crop yields simulated with EPIC were used as inputs into the stochastic version ofFASOM. We observe both substantial increases and decreases in crop yields. In general,yields increase in northern areas relative to southern areas. The patterns of simulatedyield changes <strong>for</strong> a given climate scenario, however, show significant intraregionalvariation depending on the type of crop, irrigation status, and changes in wateravailability, nutrient availability, as well as many other factors. We model crop allocationdecisions based on the relative returns and risk associated with alternative croppingpatterns under future climate scenarios. Our results show substantial changes inregional crop acreage allocation and production patterns as producers switch cropsand practices in response to changes in expected profitability and risk under climatechange, which in turn may in<strong>for</strong>m agricultural adaptation measures. <strong>Final</strong>ly, impactsestimated using FASOM are incorporated within the Applied Dynamic <strong>Analysis</strong> ofthe Global Economy (ADAGE) dynamic computable general equilibrium model toassess interactions with other sectors and macroeconomic impacts.60T3-G.4 Beaudrie CEH, Kandlikar M, Satterfield T, Herr Harthorn B; christian.beaudrie@gmail.comInstitute <strong>for</strong> Resources, Environment and Sustainability, University of British Columbia; Center <strong>for</strong>Nanotechnology in <strong>Society</strong>, University of Cali<strong>for</strong>nia Santa BarbaraEXPERT OPINION AND LIFECYCLE REGULATION FOR EMERG-ING NANOMATERIALSEngineered nanoscale materials (ENMs) present a difficult challenge <strong>for</strong> riskassessors and regulators. Assessment of risks along the life cycle of nanomaterials islimited both by a lack of inventory data (since production in<strong>for</strong>mation is scarce) andby the paucity of impact data (since exposure and toxicity data is lacking). Continuinguncertainty about potential exposure and toxicity of EMNs implies that expert opinionwill play an important role in assessing and regulating risk. This paper employsdata from a recent survey of nanotechnology experts (n=430 nano-scientists andengineers, toxicologists and regulators) alongside a comprehensive review of existingregulatory options across the lifecycle of nanomaterials. We find, overall, differencesin opinions among classes of experts about the lifecycle risk of nanomaterials; differentexpert views of responsibility and preparedness <strong>for</strong> managing any risks posedby nanomaterials; and differing perspectives on barriers to implementing a life cycleapproach to the regulation of nanomaterials and nano-based products.W4-C.4 Becker RA, Moran E, Fensterheim R, Pottenger LH; rick_becker@americanchemistry.comAmerican Chemistry CouncilRECOMMENDATIONS FOR RETOOLING IRISWe now know more than ever about biological systems, modes by which chemicalsinteract with these and dose-dependency of effects which transition from nil (homeostasis)to adaptation to adverse. Yet in IRIS assessments such knowledge seemsnever enough to supersede defaults. Criticisms of IRIS include overreliance on assumptionsinstead of data, inconsistent data evaluation/study integration methodsand opaque justifications <strong>for</strong> conclusions. Our retooling recommendations involveimprovements in data acquisition, data evaluation, risk determination, and transparency.Problem <strong>for</strong>mulation is key <strong>for</strong> data acquisition; if critical data needs are identified,a process and schedule can be agreed. Meaningful dialogue with stakeholdersduring problem <strong>for</strong>mulation should focus assessments on key issues and enable developmentof relevant peer-review charge questions to evaluate these. Retooling dataevaluation requires consistent application of uni<strong>for</strong>m criteria <strong>for</strong> determining methodvalidity, study reliability, data quality, and criteria <strong>for</strong> establishing cause and effect,coupled with a hypothesis-based weight of evidence framework <strong>for</strong> mode of actionevaluation, including evaluation of default(s). In risk determination, modernizationmeans selecting appropriate dose-response methods and conducting quantitative estimatesof central tendency <strong>for</strong> population probability risk distributions, not just upperbounds. Restructuring and enhancing public comments and peer-review processesare also needed to improve transparency and scientific integrity. Enhanced considerationof scientifically relevant public comments by the independent scientific peerreviewers, and documentation that an assessment was revised to adequately addresspeer-review findings and recommendations, should be considered. Given the importanceof IRIS assessments to EPA program offices, other federal agencies, states, andprivate & public sector impacts, retooling along the lines of our recommendations iswarranted.
W1-C.3 Belzer RB; belzer@regulatorycheckbook.orgRegulatory CheckbookFINALLY, A SCIENTIFIC DEFINITION OF ADVERSE EFFECTThe scientific assessment of human health risk has been predicated on the existenceof a scientific definition <strong>for</strong> adverse effects. Yet, ever since Arnold Lehmanintroduced the dawn of health risk assessment in 1949, and proceeding through thousandsof scholarly articles, hundreds of scholarly books, scores of National ResearchCouncil reports, dozens of Federal and State agency guidance documents, myriadlaws and regulations, and the creation in 1980 of the <strong>Society</strong> <strong>for</strong> <strong>Risk</strong> <strong>Analysis</strong>, adverseeffect still lacks a scientific definition. Channeling their inner Justice Potter Steward,theoreticians and practitioners alike profess to know an adverse effect when they seeone. This is surely true, at least <strong>for</strong> effects so bad that even an economist could recognizethem. But it is not true at the margin, where fine distinctions separate adversefrom nonadverse effects and the risk management consequence of assignment aremost meaningful. This paper reviews the domain of conventional definitions of adverseeffect, adding to them several refinements that have been recently proposed byvarious individuals and groups. It is shown that none are genuinely scientific. Someare measurable but not refutable, and all are dependent on the policy judgment of therisk assessor. Most conventional methods are further compromised because they imposethe strong assumption of monotonicity in dose-response, and thus they cannotreconcile the possibility that an effect may be adverse at some doses but beneficial atothers. <strong>Final</strong>ly, none can address the case where, at any given dose, effects may be adverse<strong>for</strong> some persons but beneficial <strong>for</strong> others, or even adverse or beneficial <strong>for</strong> thesame person at the same time. An alternative definition is proposed that is measurableand refutable, and unlike every competing definition, it is independent of the discretionand policy judgment of the risk assessor. Thus, unlike conventional definitionsand their progeny it is scientific in every respect.W2-F.1 Ben-Haim Y; yakov@technion.ac.ilTechnion - Israel Institute of TechnologyOPTIMIZING AND SATISFICING IN THE MANAGEMENT OF RISKWe admire excellence in all areas of endeavor: art, sport, science, business, andrisk management. The fastest runner wins the race and our admiration. The lowestriskdesign - all else being equal - is preferred. `Better`, almost by definition, is `moredesirable` and - by the logic of preference - the best is most preferred. The logic ofpreference is so compelling that there is a moral imperative to do our best. Optimizationalso has deep roots in the physical and natural realms. The laws of physics canbe derived from optimization principles. Biological evolution is a process of selectionof the better over the less good leading - all else being stable - to optimal morphologies.Mathematical economics was quick to adopt the imperative of optimization,which underlies modern theories of economic dynamics. Decision makers oftenface severe uncertainties. Is optimization a good strategy under uncertainty? Uncertaintyhas profound implications <strong>for</strong> any attempt to optimize the outcome of decisions.We first discuss the equity premium paradox from financial economics whichbelies the cardinality of per<strong>for</strong>mance-optimization by economic agents. We contrastper<strong>for</strong>mance-optimization with a strategy of robustly achieving critical goals. Wethen apply this concept to technological risk analysis, and consider a schematic designof a critical but risky infra-structure. <strong>Final</strong>ly, we discuss the importance of disasterrecovery as an integral part of risk management.M2-H.4 Bennett SP, Cheesebrough AJ, Waters J; bennett.steve@gmail.comUS Department of Homeland Security, Office of <strong>Risk</strong> Management and <strong>Analysis</strong>“INTELLIGENT” INTEGRATION OF INTELLIGENT ADVERSARYMODELING INTO HOMELAND SECURITY RISK ANALYSES: THEO-RY AND PRACTICEAs a risk management organization, the U.S. Department of Homeland Security(DHS) is charged with producing relevant and technically defensible risk assessmentsof a wide range of potential adverse events within its mission domain in orderto in<strong>for</strong>m and support decision making. Many of these potential adverse events, suchas pandemics and many <strong>for</strong>ms of natural disasters (as well as drug smuggling and illegalimmigration to a degree) are 1) stochastic in nature, and 2) replete with historicalfrequency and consequence data making analysis of event risks relatively straight<strong>for</strong>ward.However, many events that are intentionally initiated, such as terrorism, are neitherstochastic in nature, nor frequent enough (thankfully) to yield statistically usefulfrequency data. Currently referred to as the “intelligent adversary” problem, the abilityto estimate reasonable and defensible frequencies (or at least relative probabilities)<strong>for</strong> terrorism events is an important research focus of the Department’s risk analysiscommunity. Current DHS “solutions” to this problem have tended to assume thatprobability elicitations of relevant experts capture the equilibrium position of eventprobabilities, incorporating the adaptation, deterrence, and threat-shifting tendenciesof different adversary groups. However, there has been no lack of proposed alternativesolutions from as evidenced from the pages of <strong>Risk</strong> <strong>Analysis</strong> and other topjournals over the past two years. These alternatives have ranged from game theoreticand agent-based methods to recommendations that DHS not attempt to characterizethese likelihoods at all. This presentation will discuss a number of these proposedalternatives from both theoretical and practical perspectives and present a framework<strong>for</strong> evaluating and incorporating intelligent adversary models <strong>for</strong> estimating terrorismfrequencies/probabilities into existing Department risk analysis frameworks.61
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SECOND FLOOR Floor MapConvention Ce