Environmental Profiles of Chemical Flame-Retardant Alternatives for

Results: No mortality after 14 days; initial signs of moderate depression
Reference: Stauffer,1973b
Additional Studies and Information:
Other studies available only in secondary sources reported similar results. An acute inhalation
LC50 of >5,220 mg/m 3 was reported for Sprague-Dawley rats exposed to aerosol of TDCPP
(Amgard TDCP) (Anderson, 1990 as reported in WHO, 1998).
Acute Eye Irritation (OPPTS Harmonized Guideline 870.2400; OECD Guideline 405)
Conclusion:
The available eye irritation data were judged adequate to meet the endpoint.
Basis for Conclusion:
Two reasonably adequate studies report similar results in rabbits: mild reversible irritation of the
conjunctiva. The studies are summarized below.
Type: Acute eye irritation
Species, strain, sex, number: Rabbit, New Zealand White, sex not specified; 6
Doses: 0.1 mL
Purity: No data, Stauffer Fyrol FR-2
Vehicle: None
Method: Cited CFR [U.S. Federal Hazardous Substances Labelling Act] Section 191.12,
chapter 1, title 21. Following instillation of TDCPP, eyes were examined at 24, 48, and 72
hours.
Results: Mild conjunctival effects in 3/6 that cleared by 48 hours.
Reference: Stauffer, 1972c
Type: Acute (24-hour) eye irritation
Species, strain, sex, number: Rabbit, New Zealand White, male and female; 9 total
Doses: 0.1 mL
Purity: No data
Vehicle: None
Method: U.S. EPA Hazard Evaluation. 1978. Fed. Reg. 43: 163: pp. 37331-37402. Thirty
seconds following instillation of TDCPP, the treated eyes of three rabbits were washed, treated
eyes were not washed in 6 rabbits. The untreated eye of each animal served as a control. The
cornea, iris and conjunctiva of each eye were examined at 24, 48, and 72 hours, and at 4 and 7
days after instillation of TDCPP using the Draize scoring method.
Results: No signs of eye irritation were observed (average total Draize score of zero).
Reference: Stauffer, 1979; robust summary from Akzo-Nobel, 2001a for study dated 1979
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