Environmental Profiles of Chemical Flame-Retardant Alternatives for

As described in a robust summary, mortality was 1/10 among New Zealand White rabbits (5/sex)
that received a dose of 2,000 mg/kg [Formulation 5] (see Note e in Table 1) on intact and abraded
skin and were observed for 14 days (Ref. 54 cited in Ref. 1). Clinical signs included depression and
mild diarrhea. No gross lesions were observed at necropsy. A letter from Ref. 52 to EPA suggests
that this study was conducted under 1978 EPA proposed test guidelines.
Acute Inhalation Toxicity (OPPTS Harmonized Guideline 870.1300; OECD Guideline 403)
Conclusion:
The available acute inhalation toxicity data were judged inadequate to meet the endpoint.
Basis for Conclusion:
The only relevant data were for a study available only as a robust summary and for which the
Proprietary J content was uncertain.
As described in a robust summary, no mortality and no body weight effects were observed among
Sprague-Dawley rats (5/sex) that were exposed for 4 hours to an aerosol of [Formulation 5] (see
Note e in Table 1) at the highest attainable concentration, 3.1 mg/L (Ref. 54 cited in Ref. 1); the
particle size distribution of 2.5-2.8 :m suggests that the particles were respirable. Ruffled fur was
the only clinical sign observed over a period of 14 days. The only gross lesions observed were lung
effects (reddened or whitish coloration) in two females.
Acute Eye Irritation (OPPTS Harmonized Guideline 870.2400; OECD Guideline 405)
Conclusion:
The available eye irritation data were judged adequate to meet the endpoint.
Basis for Conclusion:
Despite some uncertainty as to the purity of test substances, the available studies used methods
equivalent to the guidelines and agreed that Proprietary J was not an eye irritant.
Type: Acute eye irritation
Species, strain, sex, number: Rabbit, New Zealand White, 3 (sex not reported)
Doses: 0.1 mL
Purity: Not reported; isomeric mixture of Proprietary J as [Formulation 7]
Vehicle: None
Method: Cites OECD Guideline 405. Eyes examined after 1 hour, then 1, 2, 3, 4, and 7 days.
Results: No positive responses; no damage to cornea or iris. Mild conjunctival inflammation was
observed in 3/3 animals 1 hour after instillation only. All normal by 24 hours.
Reference: Ref. 27
13-8