Environmental Profiles of Chemical Flame-Retardant Alternatives for

mid-dose of 20 mg/kg/day as a LOAEL. However, as evaluated in NRC (2000), the lowest dose
of 5 mg/kg/day was a LOAEL for atrophy and decreased secretory product of the seminal
vesicle.
Reference: Freudenthal and Henrich, 2000; also Bio/Dynamics (1980), fiche 27 of 32 and
Bio/Dynamics (1981) fiche 6 of 6.
CARCINOGENICITY
Conclusion:
The available carcinogenicity data were judged adequate to meet the endpoint.
Basis for Conclusion:
Increased tumor incidences were observed in a combined chronic toxicity/carcinogenicity assay
in rats exposed to TDCPP in the diet (Freudenthal and Henrich, 2000).
• Carcinogenicity (OPPTS Harmonized Guideline 870.4200; OECD Guideline 451)
No studies of this type were located.
Combined Chronic Toxicity/Carcinogenicity (OPPTS Harmonized Guideline 870.4300;
OECD Guideline 453)
A 2-year feeding bioassay by Freudenthal and Henrich (2000) was consistent with this guideline.
Type: Combined oral chronic toxicity and carcinogenicity assay
Species, strain, sex, number: Rat, Sprague-Dawley, 60/sex/group
Purity: 95%
Doses: 0, 5, 20, and 80 mg/kg body weight/day
Vehicle: None other than feed
Route: In feed; diets blended weekly to achieve target doses
Exposure duration, frequency: 2, ad lib
Method: See description above under Chronic Toxicity
Results: The following neoplastic changes compared to controls were statistically significant
(p