Environmental Profiles of Chemical Flame-Retardant Alternatives for

Doses: 0, 25, 100, and 400 mg/kg/day
Vehicle: Corn oil
Exposure duration, frequency: Once by oral gavage daily on gestational days 6-15
Method: Body weight, food consumption, clinical signs, pregnancy rates, and necropsy of dams;
uterine contents (including implants and resorption) at day 19 of gestation, corpora lutea; fetal
viability and weight, crown-rump length, external, visceral (1/3 fetuses), and skeletal
abnormalities; extensive statistical analyses.
Results: High-dose dams exhibited clinical signs (urine stains, hunched appearance, and
alopecia); sporadic signs of urine stains and hunched appearance occurred in a few mid-dose
dams, but not at the low-dose. Food consumption was statistically lower in mid-dose dams on
days 7-11 and in high-dose group throughout (days 7-15). During Days 6-11, significant
(p