Environmental Profiles of Chemical Flame-Retardant Alternatives for

histopathological effects in the nervous tissues. Conversely, the positive control hens exhibited
consistently lower body weight gain, clinical signs of toxicity (locomotor impairment and ataxia)
that became more severe with time. Histopathology results were not reported for the positive
control.
Reference: Robust summary from Ref. 4
Neurotoxicity (Adult)
Conclusion:
The available adult neurotoxicity data were judged inadequate to meet the endpoint.
Basis for Conclusion:
The chronic oral bioassay by (Ref. 9, 9a, 24) reported no lesions of the brain or spinal cord in
rats exposed to TDCPP at doses as high as 80 mg/kg/day for 2 years, but no functional tests of
neurotoxicity were performed.
• Neurotoxicity Screening Battery (OPPTS Harmonized Guideline 870.6200; OECD
Guideline 424)
No studies of this type were located.
Developmental Neurotoxicity: Developmental Neurotoxicity Study (OPPTS Harmonized
Guideline 870.6300)
Conclusion:
The available developmental neurotoxicity data were judged inadequate to meet the endpoint,
although the available tests suggest that Proprietary A is not a developmental neurotoxin.
Basis for Conclusion:
No studies of this specific design were located. A Japanese-language gavage study by Ref. 59,
described above under Developmental Toxicity, included postnatal neurobehavioral tests (open
field, water maze, rota rod, inclined screen, pain reflex, and Preyer’s reflex) of sensory and
motor function in rats. Full descriptions of these tests were not available in the English summary
and therefore could not be compared to the guideline protocol. The study reported no adverse
effect in these tests for offspring of dams that were exposed on gestational days 7-15 at doses as
high as 200 mg/kg/day (the highest tested non-lethal dose that was a LOAEL for increased
kidney weight). This study does not fully satisfy the developmental neurotoxicity endpoint
because it omitted some parameters specified under the guideline: developmental landmarks for
sexual maturity, auditory startle test, and neurohistopathological examinations.
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