Environmental Profiles of Chemical Flame-Retardant Alternatives for

Proprietary A: Chloroalkyl phosphate (1)
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ACUTE TOXICITY
Chemical Identity
Human Health Endpoints
Acute Oral Toxicity (OPPTS Harmonized Guideline 870.1100; OECD Guidelines 425, 420,
423, 401).
Conclusion:
The available acute oral toxicity data were judged adequate to meet the endpoint.
Basis for Conclusion:
Several acute oral lethality studies were available in a variety of species: rabbits, rats, and mice.
These studies were from the older (pre 1980) literature, did not report substance purity, and do
not fully conform to OPPTS or OECD guidelines, but given the magnitude of the LD50 values
the data are adequate for the evaluation of acute oral toxicity. Acute oral LD50 values generally
exceeded the current limit dose of 2,000 mg/kg. Reports that specified a 14-day observation
period are presented in detail.
Critical Studies:
Type: Acute oral toxicity
Species, strain, sex, number: Rabbit, Dutch-belted, 5 males/group
Doses: 0, 5,000, 7,500, and 10,000 mg/kg
Purity: [Formulation 2]; purity not specifically reported
Vehicle: Not reported
Method: 14-Day post-dosing observation period; observations limited to mortality, clinical
signs, and necropsy. LD50 calculated according to Litchfield and Wilcoxon.
Results: Clinical signs shortly after dosing included ataxia, weakness, and diarrhea; survivors
normal by day 9. Necropsy revealed no abnormalities. Acute oral male rabbit LD50 = 6,800
mg/kg (95% CI 5,615-8,234 mg/kg).
Reference: Robust summary from Ref. 4
Type: Acute oral toxicity
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