Environmental Profiles of Chemical Flame-Retardant Alternatives for

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Concentrations: 0, 100, 333, 1,000, 3,333, and 10,000 :g/plate. Solvent was 95% ethanol. A precipitate was present in the plates at $3,333 ug/plate; tested in triplicate; plus replicate Purity: 98% + Method: Preincubation (20 minutes) and plate incorporation (48 hours) at 37°C. Positive controls were 2-aminoanthracene for all strains with S9, and sodium azide (TA1535 and TA100), 9-aminoacridine (TA1537), and 4-nitro-o-phenylenediamine (TA98) in the absence of S9. Results: No increase over negative control at any concentration; no apparent cytotoxicity; the two highest concentrations tested may have exceeded solubility limits. Reference: Zeiger et al., 1987 Type: Bacterial reverse mutation Species, strain: Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538 Metabolic activation: Tested with and without Aroclor 1254-induced liver S9 from male Sprague-Dawley rats Concentrations: 0, 10, 100, 500, and 1,000 :g/plate. Solvent was DMSO; tested in triplicate; plus replicate Purity: No data, white crystals Method: Plate incorporation, 48 hour incubation at 37°C; apparently only one plate for each concentration. Negative and positive controls. Results: No increase in revertants over negative control at any concentration; highest concentration reportedly produced some evidence of physiological effect. Saccharomyces cerivisiae D4 also tested. Reference: Litton Bionetics, Inc., 1978a • In vitro Mammalian Cell Gene Mutation Test (OPPTS Harmonized Guideline 870.5300; OECD Guideline 476) Type: Mammalian Cell Gene Mutation Test: Forward Mutation Species, strain: Mouse lymphoma L5178Y Metabolic activation: Tested with and without Aroclor 1254-induced liver S9 from male Sprague-Dawley rats Concentrations: 0, 3.13 (only without S9), 6.26, 12.5, 25, 50, and 75 (only with S9) :g/plate. Solvent was DMSO; tested in triplicate; plus replicate Purity: No data, white crystals Method: Plate incorporation, 48 hour incubation at 37°C. Negative and positive controls (ethylmethanesulfonate without S9; dimethylnitrosamine with S9). Results: No increase over negative control at any concentration; highest concentration selected during prescreening as a level that reduced growth potential. Reference: Litton Bionetics, Inc., 1978b Other • Mitotic Gene Conversion in Saccharomyces cerevisiae (OPPTS Harmonized Guideline 870.5575) 1-24
Type: Mitotic Gene Conversion Species, strain: Saccharomyces cerevisiae D4 Metabolic activation: Tested with and without Aroclor 1254-induced liver S9 from male Sprague-Dawley rats Concentrations: 0, 10, 100, 500, and 1,000 :g/plate. Solvent was DMSO Purity: No data, white crystals Method: Plate incorporation, 3- to 5-day incubation at 30°C (without S9) or 37°C (with S9). Negative and positive controls Results: No increase over negative control at any concentration; highest concentration reportedly produced some evidence of physiological effect. Reference: Litton Bionetics, Inc. 1978a No studies were available on the genotoxicity of triphenyl phosphate in the following types of types of tests: Gene Mutation in Vivo Chromosomal Aberrations in Vitro Chromosomal Aberrations in Vivo DNA Damage and Repair 1-25
Page 1 and 2: Volume 2 Chemical Hazard Reviews Fu
Page 3 and 4: LIST OF TABLES Page 1-1 Summary of
Page 5 and 6: Flame Retardant Alternatives Triphe
Page 7 and 8: Triphenyl Phosphate: Existing Data
Page 9 and 10: Type: Acute oral LD50 Species, stra
Page 11 and 12: concentration was much higher, but
Page 13 and 14: Vehicle: Not reported, but acute or
Page 15 and 16: • 90-Day Oral Toxicity in Rodents
Page 17 and 18: Subchronic Inhalation Toxicity: 90-
Page 19 and 20: hydroureter, enlarged ureter proxim
Page 21 and 22: NEUROTOXICITY Conclusion: The avail
Page 23 and 24: Critical Studies Type: Delayed neur
Page 25 and 26: Neurotoxicity (Adult) Conclusion: T
Page 27: Species, strain, sex, number: Rat,
Page 31 and 32: Study Reference Ahrens et al., 1978
Page 33 and 34: Study Reference Geiger et al., 1986
Page 35 and 36: Study Reference Mayer et al., 1981
Page 37 and 38: Study Reference Sasaki et al., 1981
Page 39 and 40: those reported in the publicly avai
Page 43 and 44: Algal Toxicity (OPPTS Harmonized Gu
Page 45 and 46: Study Reference Millington et al.,
Page 49 and 50: Chronic Toxicity to Fish (OPPT Harm
Page 51 and 52: Chronic Toxicity to Aquatic Inverte
Page 53 and 54: Log K ow Reference 4.63 Saeger, 197
Page 55 and 56: Oxidation/Reduction: No data Oxidat
Page 57 and 58: Bioconcentration Environmental Fate
Page 59 and 60: Fish Metabolism: Conclusion: The me
Page 61 and 62: Study Type/ Method Innoculum Acclim
Page 63 and 64: Sediment/Water Biodegradation: Conc
Page 65 and 66: References Ahrens, V; Henion, J; Ma
Page 67 and 68: Dorby, A; Keller, R. 1957. Vapor pr
Page 69 and 70: Johnson, MK. 1975. Organophosphorus
Page 71 and 72: Perry, R; Green, D. 1984. Vapor pre
Page 73 and 74: Flame Retardant Alternatives Tribro
Page 75 and 76: Tribromoneopentyl alcohol: Existing
Page 77 and 78: Results: Male mortality was 2/5 at
Page 79 and 80:
Additional Study: An acute inhalati
Page 81 and 82:
application, four rabbits displayed
Page 83 and 84:
Bladder effects were seen in some o
Page 85 and 86:
• Combined Repeated Dose Toxicity
Page 87 and 88:
• Immunotoxicity (OPPTS Harmonize
Page 89 and 90:
tissue, one with rabbit tissue) sug
Page 91 and 92:
Acute Toxicity to Aquatic Organisms
Page 93 and 94:
1-Propanol, 2,2-dimethyl-, tribromo
Page 95 and 96:
Environmental Fate Bioconcentration
Page 97 and 98:
References AmeriBrom, Inc. 1982a. A
Page 99 and 100:
Flame Retardant Alternatives Tris(1
Page 101 and 102:
Tris(1,3-dichloro-2-propyl) phospha
Page 103 and 104:
Species, strain, sex, number: Rat,
Page 105 and 106:
Results: No mortality after 14 days
Page 107 and 108:
Additional Studies: Another study,
Page 109 and 110:
occurred in treated groups compared
Page 111 and 112:
high enough to induce significant r
Page 113 and 114:
Doses: 0, 25, 100, and 400 mg/kg/da
Page 115 and 116:
mid-dose of 20 mg/kg/day as a LOAEL
Page 117 and 118:
Critical Studies Type: Acute oral d
Page 119 and 120:
English summary and therefore could
Page 121 and 122:
Basis for Conclusion: TDCPP has bee
Page 123 and 124:
Gene Mutation in Vivo: C Sex-linked
Page 125 and 126:
TDCPP administered as 2,000 mg/kg b
Page 127 and 128:
Another study showed that the 96-ho
Page 129 and 130:
Study Reference Akzo- Nobel, Inc.,
Page 131 and 132:
Study Reference Sasaki et al., 1981
Page 133 and 134:
Table 3-2. Summary of available acu
Page 135 and 136:
hours (Unpublished study conducted
Page 137 and 138:
Terrestrial Organism Toxicity Acute
Page 139 and 140:
Oxidation/Reduction: No data Meltin
Page 141 and 142:
pH: This chemical does not contain
Page 143 and 144:
Species Rate Comment Reference Kill
Page 145 and 146:
Pyrolysis Products Reference When h
Page 147 and 148:
Brusick, D; Matheson, D; Jagannath,
Page 149 and 150:
Majeska, JB; Matheson, DW. 1983. Qu
Page 151 and 152:
Thomas, MB; Collier, TA. 1985. Tolg
Page 153 and 154:
Proprietary A: Chloroalkyl phosphat
Page 155 and 156:
Proprietary A: Chloroalkyl phosphat
Page 157 and 158:
Basis for Conclusion: The available
Page 159 and 160:
Additional Studies and Information:
Page 161 and 162:
Conclusion: The available subchroni
Page 163 and 164:
Basis for Conclusion: No repeated-e
Page 165 and 166:
Prenatal Developmental Toxicity Stu
Page 167 and 168:
Combined Chronic Toxicity/Carcinoge
Page 169 and 170:
Basis for Conclusion: The delayed n
Page 171 and 172:
histopathological effects in the ne
Page 173 and 174:
Immunotoxicity (OPPTS Harmonized Gu
Page 175 and 176:
C In vitro Mammalian Cell Gene Muta
Page 177 and 178:
Chromosomal Aberration in Vivo: C M
Page 179 and 180:
Aquatic Organism Toxicity Ecotoxici
Page 181 and 182:
Study Reference Species Tested Ref.
Page 183 and 184:
Page 185 and 186:
Acute Toxicity to Freshwater Invert
Page 187 and 188:
Chronic Toxicity to Freshwater and
Page 189 and 190:
Page 191 and 192:
CAS MF MW SMILES Physical/Chemical
Page 193 and 194:
Vapor Pressure (torr//C) Reference
Page 195 and 196:
Bioconcentration Environmental Fate
Page 197 and 198:
Study type/ Method Innoculum Acclim
Page 199 and 200:
Flame Retardant Alternatives Propri
Page 201 and 202:
Proprietary B: Aryl phosphate Exist
Page 203 and 204:
ACUTE TOXICITY Human Health Endpoin
Page 205 and 206:
Additional Studies and Information:
Page 207 and 208:
were elevated in all treated groups
Page 209 and 210:
Basis for Conclusion: No pertinent
Page 211 and 212:
Experiment B. Doses were chosen bas
Page 213 and 214:
These studies may be indicated, for
Page 215 and 216:
• Mammalian Bone Marrow Chromosom
Page 217 and 218:
• Algal Toxicity (OPPTS Harmonize
Page 219 and 220:
Bioconcentration Fish: No data Daph
Page 221 and 222:
Flame Retardant Alternatives Propri
Page 223 and 224:
Proprietary C: Chloroalkyl phosphat
Page 225 and 226:
Basis for Conclusion: Acute oral to
Page 227 and 228:
Acute Eye Irritation (OPPTS Harmoni
Page 229 and 230:
Critical Studies: Type: Dermal sens
Page 231 and 232:
C Reproduction/Developmental Toxici
Page 233 and 234:
• Combined Chronic Toxicity/Carci
Page 235 and 236:
Gene Mutation in Vitro: • Bacteri
Page 237 and 238:
Page 239 and 240:
• Acute Oral Toxicity in Birds (O
Page 241 and 242:
Corrosion Characteristics: No data
Page 243 and 244:
determined at 50°C and it was foun
Page 245 and 246:
Proprietary D: Reactive brominated
Page 247 and 248:
Chemical Identity Proprietary D: Re
Page 249 and 250:
Acute Dermal Irritation (OPPTS Harm
Page 251 and 252:
• Prenatal Developmental Toxicity
Page 253 and 254:
Gene Mutation in vitro C Bacterial
Page 255 and 256:
• Chronic Toxicity to Freshwater
Page 257 and 258:
Page 259 and 260:
Proprietary E: Tetrabromophthalate
Page 261 and 262:
Proprietary E: Tetrabromophthalate
Page 263 and 264:
• Reproduction and Fertility Effe
Page 265 and 266:
GENOTOXICITY Conclusion: No availab
Page 267 and 268:
Acute and Subchronic Toxicity to Te
Page 269 and 270:
Page 271 and 272:
Proprietary F: Halogenated aryl est
Page 273 and 274:
Proprietary F: Halogenated aryl est
Page 275 and 276:
REPRODUCTIVE TOXICITY Conclusion: N
Page 277 and 278:
• Neurotoxicity Screening Battery
Page 279 and 280:
Page 281 and 282:
Henry’s Law Constant: No data 9-1
Page 283 and 284:
Anaerobic Biodegradation: No data P
Page 285 and 286:
Proprietary G: Triaryl phosphate, i
Page 287 and 288:
Page 289 and 290:
Acute Inhalation Toxicity (OPPTS Ha
Page 291 and 292:
SUBCHRONIC TOXICITY Subchronic Oral
Page 293 and 294:
• Prenatal Developmental Toxicity
Page 295 and 296:
Composition of Proprietary G assaye
Page 297 and 298:
Several components of the [Formulat
Page 299 and 300:
As described in unvalidated robust
Page 301 and 302:
Page 303 and 304:
Page 305 and 306:
Sediment/Water Biodegradation: No d
Page 307 and 308:
Proprietary H: Halogenated aryl est
Page 309 and 310:
Proprietary H: Halogenated aryl est
Page 311 and 312:
REPRODUCTIVE TOXICITY Conclusion: N
Page 313 and 314:
IMMUNOTOXICITY Conclusion: No avail
Page 315 and 316:
Page 317 and 318:
Henry’s Law Constant: No data 11-
Page 319 and 320:
Page 321 and 322:
Proprietary I: Organic phosphate es
Page 323 and 324:
Proprietary I: Organic phosphate es
Page 325 and 326:
Page 327 and 328:
CARCINOGENICITY Conclusion: No avai
Page 329 and 330:
No studies were located that were r
Page 331 and 332:
• Chronic Toxicity to Freshwater
Page 333 and 334:
Explosivity: No data Corrosion Char
Page 335 and 336:
Page 337 and 338:
Proprietary J: Aryl phosphate Exist
Page 339 and 340:
Proprietary J: Aryl phosphate Synon
Page 341 and 342:
Results: No deaths. Clinical signs
Page 343 and 344:
As described in a robust summary, m
Page 345 and 346:
third animal on days 2 and 3 only.
Page 347 and 348:
however, identify target organs tha
Page 349 and 350:
Basis for Conclusion: The only avai
Page 351 and 352:
Basis for Conclusion: The available
Page 353 and 354:
EPA proposed guidelines (Ref. 58).
Page 355 and 356:
[Formulation 2] (typically 43% Prop
Page 357 and 358:
No additional, pertinent acute toxi
Page 359 and 360:
Proprietary J: Aryl phosphate CAS M
Page 361 and 362:
Odor: No data Oxidation/Reduction C
Page 363 and 364:
Bioconcentration Environmental Fate
Page 365 and 366:
Degradation and Transport Photolysi
Page 367 and 368:
Sediment Temp. T 1/2 Comments Refer
Page 369 and 370:
Proprietary K: Aryl phosphate Exist
Page 371 and 372:
Proprietary K: Aryl phosphate CAS M
Page 373 and 374:
Page 375 and 376:
Page 377 and 378:
Page 379 and 380:
Page 381 and 382:
Proprietary L: Aryl phosphate Exist
Page 383 and 384:
Proprietary L: Aryl phosphate Synon
Page 385 and 386:
Page 387 and 388:
Page 389 and 390:
Page 391 and 392:
Page 393:
United States Environmental Protect
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