Environmental Profiles of Chemical Flame-Retardant Alternatives for

Additional Studies and Information:
One hour following application of Tolgard TDCP MK1 to the eyes of New Zealand White
rabbits, slight conjunctival redness and slight discharge were noted (Cuthbert and Jackson, 1990
as reported in WHO, 1998); effects cleared by 24 hours.
Acute Dermal Irritation (OPPTS Harmonized Guideline 870.2500; OECD Guideline 404)
Conclusion:
The available dermal irritation data were judged adequate to meet the endpoint.
Basis for Conclusion:
Two reasonably adequate studies, patterned after guidelines in effect at the time, provide similar
results, indicating that TDCPP was a non-irritant when applied for 4 hours (consistent with
current guidelines) and a mild irritant when applied for 24 hours to rabbit skin. Additional
studies provide support. The studies are summarized below.
Critical Studies:
Type: Acute (24-hour) dermal irritation
Species, strain, sex, number: Rabbit, New Zealand, sex not specified, 6
Doses: 0.5 mL
Purity: Not reported; Stauffer Fyrol FR-2
Vehicle: None
Method: Cites “EPA protocol”. Back hair was shaved, each rabbit tested on intact and abraded
skin, occlusive dressing removed after 24 hours, observations at 24 and 72 hours.
Results: No edema on intact or abraded skin in any of the 6 rabbits. Mild erythema was visible
at 24 hours but cleared by 72 hours, resulting in a score of 0.63. The report classified TDCPP as
a mild irritant.
Reference: Stauffer, 1979
Type: Acute (4-hour) dermal irritation
Species, strain, sex, number: Rabbit, not specified (but New Zealand white rabbits were used in
an eye irritation test conducted at the same time)
Doses: 0.5 mL
Purity: Not reported; Stauffer Fyrol FR-2
Vehicle: None
Method: Back hair shaved, each rabbit tested on intact and abraded skin, occlusive dressing
removed after 4 hours, observations at 4, 24 and 48 hours.
Results: No erythema or edema on intact or abraded skin in any of the 6 rabbits.
Reference: Stauffer, 1972c
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