Environmental Profiles of Chemical Flame-Retardant Alternatives for

[Formulation 2] (typically 43% Proprietary J, see Table 1) at concentrations between 0.011 and 0.1
:L/mL (0.2 :L/mL was cytotoxic) did not induce forward mutations in cultured mouse lymphoma
L5178Y/TK +/- cells with or without metabolic activation (Ref. 37).
As described in a robust summary, [Formulation 5] (see Note e in Table 1) at concentrations
between 0.975 and 125 nL/mL ($15.6 nL/mL was cytotoxic) did not induce forward mutations in
cultured mouse lymphoma L5178Y/TK +/- cells with or without metabolic activation (Ref. 39).
Chromosomal Aberration in Vitro
• In Vitro Mammalian Chromosome Aberration Test (OPPTS Harmonized Guideline
870.5375)
As described in a robust summary, [Formulation 5] (see Note e in Table 1) at concentrations
between 0.625 and 20 nL/mL ($2.5 nL/mL was cytotoxic) did not increase the frequency of
chromosomal aberrations in cultured mouse lymphoma L5178Y/TK +/- cells with or without
metabolic activation (Ref. 40).
No studies were located that were relevant to the categories listed below.
Gene Mutation in Vivo
Chromosomal Aberration in Vivo
DNA Damage and Repair
Other
• In vitro Sister Chromatid Exchange Assay (OPPTS Harmonized Guideline 870.5900)
As described in a robust summary, [Formulation 5] (see Note e in Table 1) at concentrations
between 0.625 and 20 nL/mL ($2.5 nL/mL was cytotoxic) did not increase the frequency of sister
chromatid exchanges in cultured mouse lymphoma L5178Y/TK +/- cells with or without metabolic
activation (Ref. 40).
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