Environmental Profiles of Chemical Flame-Retardant Alternatives for

concentration was much higher, but no signs of toxicity and no deaths were observed. Analysis
of particle size, however, was not mentioned, so it is not known whether the size was respirable.
Necropsies apparently were not performed. The other available study, on TPP vapor (Sutton et
al., 1960), was conducted at an exposure level lower than recommended for a limit test, the
observation period was inadequate, and it appears that the chamber was a closed chamber, which
is not according to guideline.
Type: Acute inhalation toxicity
Species, strain, sex, number: Rat, Wistar, 5 males and 5 females
Doses: 200 mg/L (nominal); administered as a powder; particle size not reported
Purity: No data, commercial product provided by Monsanto, white flakes
Vehicle: None
Duration: 1 hour
Method: 16 CFR 1500.3; 300 mL chamber with air flow of 5 L/minute. Observation period =
14 days. Observed daily for signs of toxicity and for mortality.
Results: Mortality after 14 days 0/5 males, 0/5 females; no overt signs of toxicity
Reference: Food and Drug Research Labs, 1976
Type: Acute inhalation toxicity
Species, strain, sex, number: Mouse, Carworth Farms CF 1, male
Doses, duration, number: 363 mg/m 3 (6 hours exposure, 5 mice) and 757 mg/m 3 (2 and 4 hours
exposure, 7 mice/duration)
Purity: Practical Grade Eastman
Vehicle: None
Method: The mice were exposed to TPP vapor in a battery jar following generation of the vapor
by flowing preheated air through molten TPP at 175-180°C. Observation period = 24 hours.
The mice were observed for signs of cholinergic toxicity and blood cholinesterase was measured
at termination.
Results: No overt signs of toxicity; cholinesterase determinations not considered valid because
controls did not appear to have been sham exposed.
Reference: Sutton et al., 1960
Acute Eye Irritation (OPPTS Harmonized Guideline 870.2400; OECD Guideline 405)
Conclusion:
The available eye irritation data were judged adequate to meet the endpoint.
Basis for Conclusion:
Two reasonably adequate studies report similar results in rabbits: mild reversible irritation
primarily of the conjunctiva. The studies are summarized below.
Type: Acute eye irritation
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