Environmental Profiles of Chemical Flame-Retardant Alternatives for

Subchronic Inhalation Toxicity: 90-Day Inhalation Toxicity (OPPTS Harmonized
Guideline 870.3465; OECD Guideline 413)
Conclusion:
No available subchronic inhalation toxicity data.
Basis for Conclusion:
No repeated-exposure inhalation toxicity studies were located.
REPRODUCTIVE TOXICITY
Conclusion:
The available reproductive toxicity data were judged inadequate to meet the endpoint.
Basis for Conclusion:
A study of reproduction and development in rats exposed for 91 days prior to mating, and
continuing through mating until day 20 of gestation (Welsh et al., 1987) partially characterizes
this endpoint, but is not fully adequate. No other data relevant to this endpoint were located.
• Reproduction/Developmental Toxicity Screening (OPPTS Harmonized Guideline
870.3550; OECD Guideline 421)
A study of reproduction and development in rats exposed for 91 days prior to mating, and
continuing through mating until day 20 of gestation (Welsh et al., 1987) partially satisfies the
reproductive screening component of this guideline, but is not fully adequate, primarily because
it lacks histopathology of male and female reproductive organs. The study is summarized below
under Developmental Toxicity. Findings relevant to reproduction were that there were no
significant differences in number of corpora lutea, implants, implantation efficiency, viable
fetuses, and number of early or late deaths at dietary levels as high as 1.0% TPP (690
mg/kg/day). Because both sexes were treated, and there were no effects on litter size (as
measured by number of viable fetuses), the study provides some evidence that fertility is not
affected by TPP in the rat.
• Combined Repeated Dose Toxicity Study with the Reproduction/Developmental
Toxicity Screening Test (OPPTS Harmonized Guideline 870.3650; OECD Guideline
422)
No studies with this specific design were available.
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