Environmental Profiles of Chemical Flame-Retardant Alternatives for

Chronic Toxicity to Fish (OPPT Harmonized Guideline 850.1400; OECD Guideline 210)
Conclusion:
C The currently available data were judged adequate to meet the chronic toxicity endpoint
for freshwater fish.
C The currently available data were judged inadequate to meet the chronic toxicity endpoint
for saltwater fish.
Basis for Conclusion:
Freshwater Fish
A confidential study for chronic toxicity to freshwater fish was submitted. The study results
indicated a Fish ChV of 0.140 mg/L. These data were judged adequate to meet this endpoint.
Publicly available data are summarized in Table 1-4. Two chronic studies in fish were located.
Both studies were published in Mayer et al. (1981). The study in fathead minnows reported a
NOAEC of 87 :g/L and a LOAEC of 230 :g/L. The study used flow-through conditions and
analytically confirmed the test concentrations; however, the study is considered invalid due to
the large variation in measured concentrations (55-170 :g/L at the NOAEC and 140-390 :g/L at
the LOAEC). The study in rainbow trout is considered to be inadequate because the highest
concentration tested was 1.4 :g/L, a concentration that did not elicit any effects. Also, the
measured concentrations were not given. Therefore, validity of the test could not be
independently evaluated.
Saltwater Fish
No chronic toxicity studies in saltwater fish species were located.
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