Environmental Profiles of Chemical Flame-Retardant Alternatives for

Another study showed that the 96-hour LC 50 of Proprietary A in rainbow trout (currently
classified as Oncorhynchus mykiss) was 1.4 mg/L (95% CI: 0.9-1.9 mg/L) (Unpublished study
conducted in 1990, summarized in Ref. 4, 5). A NOEC was not observed since one fish died at
0.63 mg/L, the lowest concentration tested. Compound purity was not provided in the summary
and the reported concentrations of Proprietary A in the test water appear to be nominal values.
The guideline for acute toxicity in fish (OPPTS 850.1075) indicates that test concentrations must
be measured during the test if, as was the case in this study, aeration is used. Thus, the study
reported by Ref. 4, 5 does not meet the criteria established by the guideline. The studies by Ref.
46 and Ref. 4, 5 suggest that the 96-hour LC 50 for Proprietary A in fish is in the range of 1 to 5
mg/L, making it moderately toxic to fish. However, the data are inadequate to satisfy the acute
toxicity endpoint for freshwater fish. A 96-hour LC 50 of 1.1 mg/L and a NOEC of 0.56 mg/L for
Proprietary A in rainbow trout (Ref. 42) were reported in Ref. 29. Although the results of the
study by Ref. 42 are in agreement with those of Ref. 4, 5, the study by Ref. 42, or a study
summary, was not available to allow for an independent evaluation of these data. Confirmation
of the results of the study by Ref. 42 might allow the acute toxicity endpoint for freshwater fish
to be satisfied.
Marine Fish
No acute toxicity studies in saltwater fish species were located.
4-29