Environmental Profiles of Chemical Flame-Retardant Alternatives for

Acute Toxicity to Freshwater Invertebrates (OPPTS Harmonized Guideline 850.1010;
OECD 202)
Conclusion:
The available acute toxicity data for freshwater invertebrates were judged inadequate to meet the
endpoint. However, if the results of the study cited by IPCS (1998) (see below) are confirmed
independently, the data might meet the endpoint given the high degree of agreement of the two
available studies in freshwater invertebrates.
Basis for Conclusion:
The available data are summarized in Table 3-2. A flow-through study revealed a 48-hour LC 50
of TDCPP with Daphnia magna of 3.8 mg/L (95% CI: 3.5-4.2 mg/L) and a NOEC of 1.6 mg/L
(Unpublished study conducted in 1999, summarized in Akzo-Nobel, Inc., 2001a,b). Although
some of the conditions of the study design (such as number of organisms, and water temperature
and chemistry) appear to meet OPPTS Harmonized Guideline 850.1010, other aspects of the
study, including compound purity and condition and fertility of the organisms in culture, were
not reported in the summary. The amount of solvent used in the control group and the TDCPP
treatments might have exceeded the recommended maximum solvent concentration, as per the
OPPTS Guideline (100 mg/L), but this does not appear to have affected the study results. A 48hour
LC 50 of 4.6 mg/L and a NOEC of 1.8 mg/L were reported for daphnia in a study by
SafePharm (1993b), as cited in IPCS (1998). Although the results of the study by SafePharm
(1993b) are in agreement with those of Akzo-Nobel, Inc. (2001a,b), the study by SafePharm
(1993b), or a study summary, was not available to allow for an independent evaluation of these
data. Confirmation of the results of the study by SafePharm (1993b) might allow the acute
freshwater invertebrate toxicity endpoint to be satisfied.
Acute Toxicity to Marine/Estuarine Invertebrates (OPPTS Harmonized Guideline
850.1035)
Conclusion:
No available acute marine/estuarine invertebrate toxicity data.
Basis for Conclusion:
No acute toxicity studies in marine/estuarine invertebrate species were located.
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