Environmental Profiles of Chemical Flame-Retardant Alternatives for

English summary and therefore could not be compared to the guideline protocol. The study
reported no adverse effect in these tests for offspring of dams that were exposed on gestational
days 7-15 at doses as high as 200 mg/kg/day (the highest tested non-lethal dose that was a
LOAEL for increased kidney weight). This study does not fully satisfy the developmental
neurotoxicity endpoint because it omitted some parameters specified under the guideline:
developmental landmarks for sexual maturity, auditory startle test, and neurohistopathological
examinations.
Additional neurotoxicity studies:
• Schedule-Controlled Operant Behavior (mouse or rat)
• OPPTS Harmonized Guideline 870.6500
• Peripheral Nerve Function (rodent)
• OPPTS Harmonized Guideline 870.6850
• Sensory Evoked Potentials (rat, pigmented strain preferred)
• OPPTS Harmonized Guideline 870.6855
These studies may be indicated, for example, to follow up neurotoxic signs seen in other studies,
or because of structural similarity of the substance to neurotoxicants that affect these endpoints.
These studies may be combined with other toxicity studies.
Conclusion: These endpoints do not appear to be applicable to TDCPP.
Basis for Conclusion: Although there are no studies addressing these endpoints, there are no
reliable data for TDCPP, and no structure-activity considerations, that indicate a need for these
follow-up studies.
Other Neurotoxicity Data
Cholinesterase inhibition
Fyrol FR-2 administered at 0, 2,000, or 3,980 mg/kg in corn oil was administered to groups of 10
male Sprague-Dawley rats by oral gavage had no effect on plasma or erythrocyte cholinesterase
levels measured 4 or 14 hours after dosing (Stauffer, 1972b).
IMMUNOTOXICITY
Conclusion:
The available immunotoxicity data were judged inadequate to meet the endpoint.
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