Environmental Profiles of Chemical Flame-Retardant Alternatives for

Basis for Conclusion:
The available studies predate the preferred study guidelines, and did not report purity, but
together indicated no mortality at the guideline limit dose of 2,000 mg/kg. The report specifying
a 14-day observation period is presented in more detail.
Type: Acute dermal toxicity
Species, strain, sex, number: Rabbit, New Zealand albino, sex not specified, 4
Dose: 4,640 mg/kg
Purity: [Formulation 2], no data
Vehicle: None
Exposure period: 24 Hour
Method: 4 Rabbits tested occluded; 14-day observation period. Gross necropsy.
Results: Mortality after 14 days = 0/4. No overt signs of toxicity and no gross necropsy
findings. Therefore, dermal acute LD50 >4,640 mg/kg.
Reference: Ref. 54; additional information from robust summary in Ref. 4
Additional Studies and Information:
Other studies available only in secondary sources with minimal detail. A dermal LD50 of
>2,000 mg/kg was reported in male and female Sprague-Dawley rats exposed to [Formulation 3]
(Ref. 19 as reported in Ref. 61). No deaths and no clinical signs were noted 24 hours after
treatment.
Acute Inhalation Toxicity (OPPTS Harmonized Guideline 870.1300; OECD Guideline 403)
Conclusion:
The available acute inhalation toxicity data were judged inadequate to meet the endpoint.
Basis for Conclusion:
The available study on Proprietary A predates the preferred guidelines. The duration was shorter
than currently recommended and no deaths were observed. Analysis of aerosol particle size,
however, was not mentioned so it is not known whether the size was respirable. Necropsies
were not performed.
Type: Acute inhalation toxicity
Species, strain, sex, number: Rat, Sprague-Dawley, 5 males and 5 females
Doses: 9.8 mg/L (9,800 mg/m 3 )
Purity: No data
Vehicle: None
Duration: 1 hour
Method: Observation period = 14 days. Observed daily for signs of toxicity and for mortality.
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