Environmental Profiles of Chemical Flame-Retardant Alternatives for

Results: No mortality after 14 days; initial signs of moderate depression
Reference: Ref. 55
Additional Studies and Information:
Other studies available only in secondary sources reported similar results. An acute inhalation
LC50 of >5,220 mg/m 3 was reported for Sprague-Dawley rats exposed to aerosol of Proprietary
A [Formulation 1] (Ref. 7 as reported in Ref. 61).
Acute Eye Irritation (OPPTS Harmonized Guideline 870.2400; OECD Guideline 405)
Conclusion:
The available eye irritation data were judged adequate to meet the endpoint.
Basis for Conclusion:
Two reasonably adequate studies report similar results in rabbits: mild reversible irritation of the
conjunctiva. The studies are summarized below.
Type: Acute eye irritation
Species, strain, sex, number: Rabbit, New Zealand White, sex not specified; 6
Doses: 0.1 mL
Purity: No data, [Formulation 2]
Vehicle: None
Method: Cited CFR [U.S. Federal Hazardous Substances Labelling Act] Section 191.12,
chapter 1, title 21. Following instillation of Proprietary A, eyes were examined at 24, 48, and 72
hours.
Results: Mild conjunctival effects in 3/6 that cleared by 48 hours.
Reference: Ref. 52
Type: Acute (24-hour) eye irritation
Species, strain, sex, number: Rabbit, New Zealand White, male and female; 9 total
Doses: 0.1 mL
Purity: No data
Vehicle: None
Method: U.S. EPA Hazard Evaluation. 1978. Fed. Reg. 43: 163: pp. 37331-37402. Thirty
seconds following instillation of Proprietary A, the treated eyes of three rabbits were washed,
treated eyes were not washed in 6 rabbits. The untreated eye of each animal served as a control.
The cornea, iris and conjunctiva of each eye were examined at 24, 48, and 72 hours, and at 4 and
7 days after instillation of Proprietary A using the Draize scoring method.
Results: No signs of eye irritation were observed (average total Draize score of zero).
Reference: Ref. 57; robust summary from Ref. 4
4-7