Bulletin 2010/45 - European Patent Office
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(C07D) I.1(1)<br />

(51) C07D 333/40 (11) 2 247 583 A1*<br />

A61K 31/381 A61K 31/5377<br />

A61P 27/06<br />

(25) En (26) En<br />

(21) 09703976.2 (22) 15.01.2009<br />

(84) AT BE BG CH CY CZ DE DK EE ES FI FR GB<br />

GR HR HU IE IS IT LI LT LU LV MC MK MT<br />

NL NO PL PT RO SE SI SK TR<br />

AL BA RS<br />

(86) US 2009/031081 15.01.2009<br />

(87) WO 2009/094286 2009/31 30.07.2009<br />

(30) 24.01.2008 US 23365 P<br />

14.01.2009 US 353290<br />

(54) • HYDRAZINE IN DER GLAUKOMTHERAPIE<br />

• HYDRAZINES IN GLAUCOMA THERAPY<br />

• HYDRAZINES DANS LA THÉRAPIE DU<br />

GLAUCOME<br />

(71) ALLERGAN, INC., 2525 Dupont Drive, Irvine,<br />

CA 92612, US<br />

(72) OLD, David, W., Irvine CA 92620, US<br />

DINH, Danny, T., Garden Grove CA 92840,<br />

US<br />

(74) HOFFMANN EITLE, <strong>Patent</strong>- und Rechtsanwälte<br />

Arabellastrasse 4, 81925 München, DE<br />

(51) C07D 401/04 (11) 2 247 584 A1*<br />

C07D 413/14 C07D 417/04<br />

C07D 417/14 A61K 31/4709<br />

A61P 9/00 A61P 35/00<br />

A61P 37/00 A61P 27/02<br />

(25) En (26) En<br />

(21) 09704615.5 (22) 26.01.2009<br />

(84) AT BE BG CH CY CZ DE DK EE ES FI FR GB<br />

GR HR HU IE IS IT LI LT LU LV MC MK MT<br />

NL NO PL PT RO SE SI SK TR<br />

AL BA RS<br />

(86) GB 2009/000211 26.01.2009<br />

(87) WO 2009/093049 2009/31 30.07.2009<br />

(30) 25.01.2008 GB 0801416<br />

(54) • KONDENSIERTE PYRIDINE, DIE ALS<br />

INHIBITOREN VON C-MET WIRKEN<br />

• FUSED PYRIDINES ACTIVE AS INHIBI-<br />

TORS OF C-MET<br />

• PYRIDINES CONDENSÉES ACTIVES À<br />

TITRE D'INHIBITEURS DE C-MET<br />

(71) F. Hoffmann-La Roche AG, Grenzacherstrasse<br />

124, 4070 Basel, CH<br />

(72) FOLKES, Adrian, John, 4070 Basel, CH<br />

GOLDSMITH, Paul, 4070 Basel, CH<br />

PEGG, Neil, Anthony, 4070 Basel, CH<br />

(74) Keen, Celia Mary, J.A. Kemp & Co. 14 South<br />

Square Gray's Inn, GB-London WC1R 5JJ,<br />

GB<br />

C07D 401/04 → (51) C07D 209/42<br />

C07D 401/12 → (51) C07D 239/94<br />

C07D 403/04 → (51) C07D 241/44<br />

(51) C07D 403/06 (11) 2 247 585 A1*<br />

A61K 31/404 A61P 35/00<br />

(25) En (26) En<br />

(21) 09717772.9 (22) 05.03.2009<br />

(84) AT BE BG CH CY CZ DE DK EE ES FI FR GB<br />

GR HR HU IE IS IT LI LT LU LV MC MK MT<br />

NL NO PL PT RO SE SI SK TR<br />

AL BA RS<br />

(86) EP 2009/001568 05.03.2009<br />

(87) WO 2009/109388 2009/37 11.09.2009<br />

(30) 06.03.2008 EP 08004143<br />

Europäisches <strong>Patent</strong>blatt<br />

<strong>European</strong> <strong>Patent</strong> <strong>Bulletin</strong><br />

<strong>Bulletin</strong> européen des brevets<br />

(54) • KRISTALLINE FORMEN VON N-[2-(DIE-<br />

THYLAMINO-)ETHYL]-5-[(5-FLUOR-1,2-<br />

DIHYDRO-2-OXO-3H-INDOL-3-YLIDEN-)<br />

METHYL]-2,4-DIMETHYL-1H-PYRROL-3-<br />

CARBOXAMID UND VERFAHREN ZU<br />

IHRER HERSTELLUNG<br />

• CRYSTAL FORMS OF N-Ý2-(DIETHYLA-<br />

MINO)ETHYL¨-5-Ý(5-FLUORO-1,2-DIHY-<br />

DRO-2-OXO-3H-INDOL-3-YLIDENE)<br />

METHYL¨-2,4-DIMETHYL-1H-PYRROLE-3-<br />

CARBOXAMIDE AND METHODS FOR<br />

THEIR PREPARATION<br />

• FORMES CRISTALLINES DU N-Ý2-(DIÉ-<br />

THYLAMINO)ÉTHYL¨-5-Ý(5-FLUORO-1,2-<br />

DIHYDRO-2-OXO-3H-INDOL-3-YLIDÈNE)<br />

MÉTHYL¨-2,4-DIMÉTHYL-1H-PYRROL-3-<br />

CARBOXAMIDE ET PROCÉDÉS POUR<br />

LEUR PRÉPARATION<br />

(71) ratiopharm GmbH, Graf-Arco-Strasse 3,<br />

89079 Ulm, DE<br />

(72) MOHAMAD, nesrin, <strong>45</strong>326 Essen, DE<br />

BOESE, Roland, <strong>45</strong>326 Essen, DE<br />

LATZ, Rüdiger, 46047 Oberhausen, DE<br />

STRIEGEL, Hans-Günter, 89143 Blaudeuren,<br />

DE<br />

(74) Teipel, Stephan, et al, Lederer & Keller<br />

<strong>Patent</strong>anwälte Prinzregentenstrasse 16,<br />

80538 München, DE<br />

(51) C07D 403/12 (11) 2 247 586 A1*<br />

C07D 405/12 C07D 417/06<br />

C07D 417/14 C07D 471/04<br />

C07D 493/04 C07D 495/04<br />

C07D 513/04 A61K 31/427<br />

A61K 31/4709 A61P 25/00<br />

(25) En (26) En<br />

(21) 09711685.9 (22) 19.02.2009<br />

(84) AT BE BG CH CY CZ DE DK EE ES FI FR GB<br />

GR HR HU IE IS IT LI LT LU LV MC MK MT<br />

NL NO PL PT RO SE SI SK TR<br />

AL BA RS<br />

(86) IB 2009/050689 19.02.2009<br />

(87) WO 2009/104155 2009/35 27.08.2009<br />

(30) 21.02.2008 PCT/IB2008/050622<br />

(54) • 2-AZA-BICYCLO-[2,2,1-]HEPTAN-DERI-<br />

VATE<br />

• 2-AZA-BICYCLO[2.2.1]HEPTANE DERIVA-<br />

TIVES<br />

• DÉRIVÉS DE 2-AZA-BICYCLO[2.2.1]HEP-<br />

TANE<br />

(71) Actelion Pharmaceuticals Ltd., Gewerbestrasse<br />

16, 4123 Allschwil, CH<br />

(72) AISSAOUI, Hamed, F-68840 Pulversheim, FR<br />

BOSS, Christoph, CH-4123 Allschwil, CH<br />

KOBERSTEIN, Ralf, 79539 Lörrach, DE<br />

SIFFERLEN, Thierry, F-68220 Wentzwiller,<br />

FR<br />

TRACHSEL, Daniel, CH-4416 Bubendorf, CH<br />

(74) Ruhlmann, Eric, Actelion Pharmaceuticals<br />

Ltd Gewerbestrasse 16, 4123 Allschwil, CH<br />

C07D 403/12 → (51) C07D 209/42<br />

C07D 403/12 → (51) C07D 239/94<br />

C07D 405/04 → (51) C07D 209/42<br />

C07D 405/04 → (51) C07D 241/44<br />

(51) C07D 405/12 (11) 2 247 587 A1*<br />

C07D 417/12 A61K 31/427<br />

A61K 31/4427 A61P 3/04<br />

A61P 3/10<br />

(25) En (26) En<br />

(21) 09716230.9 (22) 05.02.2009<br />

(84) AT BE BG CH CY CZ DE DK EE ES FI FR GB<br />

GR HR HU IE IS IT LI LT LU LV MC MK MT<br />

NL NO PL PT RO SE SI SK TR<br />

73<br />

Anmeldungen<br />

Applications<br />

Demandes (<strong>45</strong>/<strong>2010</strong>) 10.11.<strong>2010</strong><br />

AL BA RS<br />

(86) EP 2009/000799 05.02.2009<br />

(87) WO 2009/109270 2009/37 11.09.2009<br />

(30) 01.03.2008 EP 08003856<br />

(54) • 5-OXO-2,3,4,5-TETRAHYDRO-BENZO[B]<br />

OXEPIN-4-CARBOXYLSÄURE-AMIDE UND<br />

2,3-DIHYDRO-BENZO[B]OXEPIN-4-CAR-<br />

BOXYLSÄURE-AMIDE ZUR BEHANDLUNG<br />

UND PRÄVENTION VON DIABETES TYP 1<br />

UND 2<br />

• 5-OXO-2, 3,4,5-TETRAHYDRO-BENZO[B]<br />

OXEPINE-4-CARBOXYLIC ACID AMIDES<br />

AND 2,3-DIHYDRO-BENZO[B]OXEPINE-4-<br />

CARBOXYLIC ACID AMIDES FOR TREAT-<br />

MENT AND PREVENTION OF DIABETES<br />

TYP 1 AND 2<br />

• AMIDES D'ACIDE 5-OXO-2,3,4,5-TÉTRA-<br />

HYDRO-BENZOÝB¨OXÉPINE-4-CARBOXY-<br />

LIQUE ET AMIDES D'ACIDE 2,3-DIHYDRO-<br />

BENZOÝB¨OXÉPINE-4-CARBOXYLIQUE<br />

POUR LE TRAITEMENT ET LA PRÉVEN-<br />

TION DU DIABÈTE DE TYPE 1 ET DE TYPE<br />

2<br />

(71) Merck <strong>Patent</strong> GmbH, Frankfurter Strasse<br />

250, 64293 Darmstadt, DE<br />

(72) SAAL, Christoph, 64853 Otzberg, DE<br />

BURGDORF, Lars, Thore, 60389 Frankfurt,<br />

DE<br />

EMDE, Ulrich, 64291 Darmstadt, DE<br />

BEIER, Norbert, 64354 Reinheim, DE<br />

GLEITZ, Johannes, 64289 Darmstadt, DE<br />

CHARON, Christine, F-91940 Gometz-le-<br />

Chatel, FR<br />

C07D 405/12 → (51) C07D 403/12<br />

C07D 409/04 → (51) C07D 209/42<br />

C07D 413/12 → (51) C07D 239/94<br />

C07D 413/14 → (51) C07D 401/04<br />

C07D 417/04 → (51) C07D 401/04<br />

C07D 417/06 → (51) C07D 403/12<br />

C07D 417/12 → (51) C07D 239/94<br />

C07D 417/12 → (51) C07D 405/12<br />

C07D 417/14 → (51) C07D 401/04<br />

C07D 417/14 → (51) C07D 403/12<br />

(51) C07D 471/04 (11) 2 247 588 A2*<br />

C07D 498/04 C07D 513/04<br />

A61P 35/00 A61K 31/4355<br />

A61K 31/4365 A61K 31/437<br />

(25) En (26) En<br />

(21) 09714922.3 (22) 25.02.2009<br />

(84) AT BE BG CH CY CZ DE DK EE ES FI FR GB<br />

GR HR HU IE IS IT LI LT LU LV MC MK MT<br />

NL NO PL PT RO SE SI SK TR<br />

AL BA RS<br />

(86) JP 2009/054007 25.02.2009<br />

(87) WO 2009/107850 2009/36 03.09.2009<br />

(88) 28.01.<strong>2010</strong><br />

(30) 26.02.2008 JP 20080<strong>45</strong>134<br />

01.10.2008 JP 2008256755<br />

(54) • KONDENSIERTES HETEROCYCLISCHES<br />

DERIVAT UND SEINE VERWENDUNG<br />

• FUSED HETEROCYCLIC DERIVATIVE AND<br />

USE THEREOF<br />

• DÉRIVÉ HÉTÉROCYCLIQUE FUSIONNÉ ET<br />

SON UTILISATION<br />

(71) Takeda Pharmaceutical Company Limited, 1-<br />

1, Doshomachi 4-chome Chuo-ku Osaka-shi,<br />

Osaka 541-00<strong>45</strong>, JP

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