A<strong>le</strong>xan<strong>de</strong>r, F. E., Jarrett, R. F., Lawrence, D., Armstrong, A. A., Freeland, J., Gokha<strong>le</strong>, D. A., Kane, E., Taylor, G. M., Wright, D. H. & Cartwright, R. A. (2000). Risk factors for Hodgkin's disease by Epstein-Barr virus (EBV) status: prior infection by EBV and other agents. Br J Cancer 82, 1117-1121. Al<strong>le</strong>n, C. D., Okada, T. & Cyster, J. G. (2007). Germinal-center organization and cellular dynamics. Immunity 27, 190-202. Anagnostopoulos, I. & Stein, H. (2000). [Large B-cell lymphomas: variants and entities]. Pathologe 21, 178-189. Ansari, A. & Emery, V. C. (1999). The U69 gene of human herpesvirus 6 enco<strong>de</strong>s a protein kinase which can confer ganciclovir sensitivity to baculoviruses. J Virol 73, 3284-3291. Aouam, K., Bel Hadj Ali, H., Youssef, M., Chaabane, A., Amri, M., Boughattas, N. A. & Zili, J. E. (2008). Carbamazepine-induced DRESS and HHV6 primary infection: the importance of skin tests. Epi<strong>le</strong>psia 49, 1630-1633. Arbuck<strong>le</strong>, J. H., Medveczky, M. M., Luka, J., Had<strong>le</strong>y, S. H., Luegmayr, A., Ablashi, D., Lund, T. C., Tolar, J., De Meir<strong>le</strong>ir, K., Montoya, J. G., Komaroff, A. L., Ambros, P. F. & Medveczky, P. G. The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro. Proc Natl Acad Sci U S A 107, 5563-5568. Armstrong, A. A., A<strong>le</strong>xan<strong>de</strong>r, F. E., Cartwright, R., Angus, B., Krajewski, A. S., Wright, D. H., Brown, I., Lee, F., Kane, E. & Jarrett, R. F. (1998). Epstein-Barr virus and Hodgkin's disease: further evi<strong>de</strong>nce for the three disease hypothesis. Leukemia 12, 1272- 1276. Asano, Y., Yoshikawa, T., Suga, S., Kobayashi, I., Nakashima, T., Yazaki, T., Kajita, Y. & Ozaki, T. (1994). Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum). Pediatrics 93, 104-108. Bai, M., Papoudou-Bai, A., Horianopoulos, N., Grepi, C., Agnantis, N. J. & Kanavaros, P. (2007). Expression of bcl2 family proteins and active caspase 3 in classical Hodgkin's lymphomas. Hum Pathol 38, 103-113. Baillargeon, J., Piper, J. & Leach, C. T. (2000). Epi<strong>de</strong>miology of human herpesvirus 6 (HHV- 6) infection in pregnant and nonpregnant women. J Clin Virol 16, 149-157. Balachandran, N., Amelse, R. E., Zhou, W. W. & Chang, C. K. (1989). I<strong>de</strong>ntification of proteins specific for human herpesvirus 6-infected human T cells. J Virol 63, 2835-2840. Bandobashi, K., Daibata, M., Kamioka, M., Tanaka, Y., Kubonishi, I., Taguchi, H., Ohtsuki, Y. & Miyoshi, I. (1997). Human herpesvirus 6 (HHV-6)-positive Burkitt's lymphoma: establishment of a novel cell line infected with HHV-6. Blood 90, 1200-1207. Barone, S. R., Kaplan, M. H. & Krilov, L. R. (1995). Human herpesvirus-6 infection in children with first febri<strong>le</strong> seizures. J Pediatr 127, 95-97. Barth, T. F., Martin-Subero, J. I., Joos, S., Menz, C. K., Hasel, C., Mechtersheimer, G., Parwaresch, R. M., Lichter, P., Siebert, R. & Mool<strong>le</strong>r, P. (2003). Gains of 2p involving the REL locus correlate with nuc<strong>le</strong>ar c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma. Blood 101, 3681-3686. Beut<strong>le</strong>r, A. S., Li, S., Nicol, R. & Walsh, M. J. (2005). Carbamazepine is an inhibitor of histone <strong>de</strong>acetylases. Life Sci 76, 3107-3115. Bhattarakosol, P., Pancharoen, C. & Mekmullica, J. (2001). Seropreva<strong>le</strong>nce of anti-human herpes virus-6 IgG antibody in children of Bangkok, Thailand. Southeast Asian J Trop Med Public Health 32, 143-147. Birnbaum, T., Padovan, C. S., Sporer, B., Rupprecht, T. A., Ausserer, H., Jaeger, G. & 162
Pfister, H. W. (2005). Severe meningoencephalitis caused by human herpesvirus 6 <strong>type</strong> B in an immunocompetent woman treated with ganciclovir. Clin Infect Dis 40, 887-889. Black, J. B., Lopez, C. & Pel<strong>le</strong>tt, P. E. (1992). Induction of host cell protein synthesis by human herpesvirus 6. Virus Res 22, 13-23. Boccara, O., Va<strong>le</strong>yrie-Allanore, L., Crickx, B. & Descamps, V. (2006). Association of hypogammaglobulinemia with DRESS (Drug Rash with Eosinophilia and Systemic Symptoms). Eur J Dermatol 16, 666-668. Bocquet, H., Bagot, M. & Roujeau, J. C. (1996). Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS). Semin Cutan Med Surg 15, 250-257. Bocquet, H., Bourgault-Villada, I., Delfau-Larue, M. H., Wechs<strong>le</strong>r, J., Revuz, J. & Roujeau, J. C. (1995). [Hypersensitivity syndrome caused by dapsone. Transient circulating clone T]. Ann Dermatol Venereol 122, 514-516. Bonnafous, P., Boutol<strong>le</strong>au, D., Naesens, L., Deback, C., Gautheret-Dejean, A. & Agut, H. (2008). Characterization of a cidofovir-resistant HHV-6 mutant obtained by in vitro se<strong>le</strong>ction. Antiviral Res 77, 237-240. Bonnafous, P., Naesens, L., Petrella, S., Gautheret-Dejean, A., Boutol<strong>le</strong>au, D., Sougakoff, W. & Agut, H. (2007). Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet. Antivir Ther 12, 877-888. Braeuninger, A., Kuppers, R., Strick<strong>le</strong>r, J. G., Wacker, H. H., Rajewsky, K. & Hansmann, M. L. (1997). Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-<strong>de</strong>rived tumor B cells. Proc Natl Acad Sci U S A 94, 9337-9342. Braun, D. K., Dominguez, G. & Pel<strong>le</strong>tt, P. E. (1997). Human herpesvirus 6. Clin Microbiol Rev 10, 521-567. Brauninger, A., Hansmann, M. L., Strick<strong>le</strong>r, J. G., Dummer, R., Burg, G., Rajewsky, K. & Kuppers, R. (1999). I<strong>de</strong>ntification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma. N Engl J Med 340, 1239-1247. Callot, V., Roujeau, J. C., Bagot, M., Wechs<strong>le</strong>r, J., Chosidow, O., Souteyrand, P., Morel, P., Dubertret, L., Avril, M. F. & Revuz, J. (1996). Drug-induced pseudolymphoma and hypersensitivity syndrome. Two different clinical entities. Arch Dermatol 132, 1315- 1321. Cao, W., Lee, S. H. & Lu, J. (2005). CD83 is preformed insi<strong>de</strong> monocytes, macrophages and <strong>de</strong>ndritic cells, but it is only stably expressed on activated <strong>de</strong>ndritic cells. Biochem J 385, 85-93. Carbone, A., Gloghini, A., Gattei, V., Aldinucci, D., Degan, M., De Paoli, P., Zagonel, V. & Pinto, A. (1995). Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines. Blood 85, 780-789. Challoner, P. B., Smith, K. T., Parker, J. D., MacLeod, D. L., Coulter, S. N., Rose, T. M., Schultz, E. R., Bennett, J. L., Garber, R. L., Chang, M. & et al. (1995). Plaqueassociated expression of human herpesvirus 6 in multip<strong>le</strong> sc<strong>le</strong>rosis. Proc Natl Acad Sci U S A 92, 7440-7444. Chatterjee, M. & Wu, S. (2001). Involvement of Fas receptor and not tumor necrosis factoralpha receptor in ultravio<strong>le</strong>t-induced activation of acid sphingomyelinase. Mol Carcinog 30, 47-55. Chen, M., Popescu, N., Woodworth, C., Berneman, Z., Corbellino, M., Lusso, P., Ablashi, 163
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Sommaire Liste des figures p.7 List
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Liste des tableaux Tableau 1 Caract
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IE immediate early Ig immunoglobuli
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Sous-famille Virus Alphaherpesvirin
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Environnement bibliographique Parti
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II.2. Génome Le génome d’HHV-6
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U2-U19 U27-U37 U38-U40 U41-U46 U48-
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sont détectés environ 3h après l
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détails ultérieurement. De façon
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a b Figure 6 : Effet cytopathogène
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XI.1. Analogues nucléosidiques L
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Acyclovir (Zovirax ®) Valacyclovir
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Partie 2 : Le syndrome d’hypersen
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jours, et pouvant atteindre 38 à 4
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Carbamazépine, phénytoïne, valpr
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III. Implication virale Une étroit
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sus-citées (figure 11). Des travau
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La reconnaissance du syndrome le pl
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A B Figure 12 : Coupe histologique
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lymphome nodulaire est surtout fré
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maladie indolente avec des récidiv
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Facteurs associés à un pronostic
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Les cellules HRS présentent un imm
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IV.3. Dérégulation de l’express
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