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UNIVERSITE DE LIMOGES ECOLE DOCTORA
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Sommaire Liste des figures p.7 List
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VI.2. Nouvelles approches p.71 Trav
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Liste des tableaux Tableau 1 Caract
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IE immediate early Ig immunoglobuli
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Sous-famille Virus Alphaherpesvirin
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Environnement bibliographique Parti
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II.2. Génome Le génome d’HHV-6
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U2-U19 U27-U37 U38-U40 U41-U46 U48-
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sont détectés environ 3h après l
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IV.4. Encapsidation Les signaux sp
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V. Effets du virus sur la cellule h
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VII. Physiopathologie de l’infect
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présence d’ADN de l’HHV-6 dans
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IX. 2. Infection des immunodéprim
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détails ultérieurement. De façon
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a b Figure 6 : Effet cytopathogène
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XI.1. Analogues nucléosidiques L
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Acyclovir (Zovirax ®) Valacyclovir
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Partie 2 : Le syndrome d’hypersen
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jours, et pouvant atteindre 38 à 4
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Carbamazépine, phénytoïne, valpr
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III. Implication virale Une étroit
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sus-citées (figure 11). Des travau
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La reconnaissance du syndrome le pl
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A B Figure 12 : Coupe histologique
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lymphome nodulaire est surtout fré
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maladie indolente avec des récidiv
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Facteurs associés à un pronostic
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Les cellules HRS présentent un imm
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IV.3. Dérégulation de l’express
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Figure 15 : Reprogrammation génét
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Un gain génétique est également
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transgéniques exprimant LMP1 déve
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Références Méthode de détection
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supprimer l’expression de la prot
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Partie 1 : Etude du rôle de l’HH
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Drogue Charge virale Figure 17 : D
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Dilution du stock viral Volume de s
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Page 84 and 85: % viabilité cellulaire 140 120 100
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Page 90 and 91: de monocytoses ou de lymphadénopat
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Page 100 and 101: IV. Article 4 Involvement of human
Page 102 and 103: I. Discussion des articles 4 et 5 L
Page 104 and 105: Récepteur Cytoplasme Figure 24 : M
Page 106 and 107: Conclusions - perspectives Ce trava
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Page 112 and 113: d’orienter la recherche de déré
Page 114 and 115: Alexander, F. E., Jarrett, R. F., L
Page 116 and 117: D. V. & DiPaolo, J. A. (1994a). Hum
Page 118 and 119: Lancet 2, 390. Dutton, A., Reynolds
Page 120 and 121: herpesvirus 6 (HHV6) and human herp
Page 122 and 123: in the IkappaBalpha gene in the mal
Page 124 and 125: development in human germinal centr
Page 126 and 127: (HHV-6) variant A from a parent to
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Page 132 and 133: Torlakovic, E., Tierens, A., Dang,
Page 134 and 135: Young, L. S. & Murray, P. G. (2003)
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