Weissbuch Version August 2013

3.3. Therapie der P. knowlesi-Malaria
• Obwohl eine Chloroquin- Therapie wirksam sein dürfte, ist
wegen der raschen Replikation und der damit verbundenen
Hyperpara­sitämie eine Therapie wie bei einer Falciparum-
Malaria empfohlen.
4. Meldung
Bitte alle Malariapatienten an Dr. Marcel Stöckle, Klinik für
­Infektiologie & Spitalhygiene, Universitätsspital Basel melden
(marcel.stoeckle@usb.ch; intern: 86635).
(Erfassung aller Malariapatienten).
5. Literatur
­ ­ 1. Alving AS, Arnold J, Hockwald RS, Clayman CB, Dern RJ, Beutler E,
Flanagan CL. Potentiation of the curative action of primaquine in vivax
malaria by quinine and chloroquine.
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2. Blum J, Tichelli A, Hatz C. Diagnostische und therapeutische Probleme
der Malaria tertiana. Praxis 1999, 88: 985-991
­ ­ 3. Cox-Singh J, Davis T Lee K et al. Plasmodium knowlesi malaria in
humans is widely distributed and potentially life threatening. CID 2008;
46:165-71
­ ­ 4. D’Acremont V, Landry P, Darioli R et al. Treatment of imported malaria
in an ambulatory setting: prospective study. Brit Med J 2002; 324:875-7
5. Dondorp A, Fanello C, Hendriksen I et al. Artesunate versus quinine in
the treatment of severe falciparum malaria in ­African children (AQUA-
MAT): an open-label, randomised trial. Lancet 2010; 376:1647-57
­ ­ 6. Hatz Ch. Malaria. In Internistische Notfälle, ­Editor Schoenenberger R.,
2009: 296-299.
­ ­ 7. Nuesch R, Scheller M, Gyr N. Hospital admissions for malaria in Basel,
Switzerland: an epidemiological review of 150 cases. J Travel Med
2000;7:95-7
8. Orton L, Gardner N. Drugs for treating uncomplicated
malaria in pregnant women.
Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004912
­ ­ 9. Riddle MS, Jackson JL, Sanders JW, Blazes DL. ­Exchange transfusion
as an adjunct therapy in severe Plasmodium ­falciparum Malaria:
A Meta-analysis. Clin Inf Dis 2002; 34:1192-8
10. South East Asian Quinine Artesunate Malaria Trial ­(SEAQUAMAT)
group. Artesunate versus quinine for treatment of severe falciparum
malaria: a randomised trial. Lancet 2005; 366:717-25
11. Vivona S, Brewer GJ, Conrad M, Alving AS. The ­concurrent weekly
administration of chloroquine and primaquine for the prevention
of Korean vivax malaria. Bull WHO 1961; 25(2):267-269
12. WHO Guidelines for the treatment of malaria. Second edition. 2010
www.fevertravel.ch
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