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Introduction to Acoustics

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884 Part F Biological and Medical <strong>Acoustics</strong><br />

Part F 21.5<br />

a)<br />

b)<br />

c)<br />

small compared <strong>to</strong> 10 m of water, so the pressure added<br />

because of the depth of the fluid can be ignored compared<br />

<strong>to</strong> atmospheric pressure. A force balance on the<br />

equa<strong>to</strong>r of the bubble equates the pressure force Pπr 2<br />

<strong>to</strong> the surface tension force σ2πr. Thus the pressure<br />

Fig. 21.64a–c Two small ultrasound imaging systems,<br />

based on the request of the Defense Advanced Research<br />

Project Administration for general-purpose handheld<br />

systems with full function (a) and (b) and an applicationspecific<br />

imaging system. (a) Terason scanner using a lap<strong>to</strong>p<br />

computer; (b) SonoSite scanner using cus<strong>to</strong>m electronics;<br />

(c) Application-specific ultrasound scanners (BladderScan)<br />

are palm-sized and fully au<strong>to</strong>matic. This instrument shows<br />

no image, but displays the volume of urine in the bladder<br />

as a number or an alarm, depending on the application<br />

in the bubble above the ambient pressure is P = 2σ/r.<br />

In the absence of a surfactant, the surface tension of<br />

water is 70 d/cm. When r = 1.4 µm, P = 1 atm; this<br />

is a huge chemical potential <strong>to</strong> drive the contained<br />

gas in<strong>to</strong> solution. If a bubble is 0.14 mm in diameter,<br />

<strong>to</strong>o large <strong>to</strong> pass through a capillary (red blood<br />

cells are 8 µm in diameter), then the pressure elevation<br />

in the bubble caused by surface tension is 0.01 atm<br />

and the gas contained in the bubble has a low driving<br />

force <strong>to</strong> diffuse in<strong>to</strong> solution. So, large bubbles<br />

are more stable than small bubbles. If the surface tension<br />

is reduced by applying a surfactant (shell) <strong>to</strong> the<br />

bubble, then small bubbles become stable. If the gas<br />

contained in the bubble is less soluble in blood and/or<br />

has a low diffusion constant, then the bubble has a longer<br />

life.<br />

Pressure<br />

MPa<br />

0.2<br />

0.1<br />

0<br />

r<br />

Fig. 21.65 Contrast agent bubble. An ultrasound contrast<br />

bubble is a system consisting of a gas inside the bubble,<br />

a surfactant, a surrounding liquid, and solutes including<br />

gases and surfactants in the liquid solvent. Thermodynamics<br />

and the transport of heat and of the dissolved gasses and<br />

dissolved surfactant materials all contribute <strong>to</strong> the response<br />

of a bubble <strong>to</strong> ultrasound exposure. Interactions between<br />

bubbles are also important fac<strong>to</strong>rs in contrast agent dynamics.<br />

Here are the expected sizes for a bubble based on<br />

an isothermal ideal gas model without considering surface<br />

tension for an ultrasound intensity of 87.5kPa<br />

r<br />

r

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