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Exotic Animal Formulary5

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the effective dose by 25% every 3 weeks; if signs relapse, return to the lowest effective dose; taper drug

dosages over a minimum of 3 weeks.

6. Client education

▪ Determine beforehand how you will document treatment response; identify target signs that can be

monitored by the owner with respect to intensity, duration, and frequency.

▪ Prepare clients for the possibility of trial and error dosing, possible side effects, the duration of treatmen

that may be necessary, and the length of time before onset of desired effects.

▪ Extra-label drug use.

Anxiolytics

Antidepressants

Characteristics

Benzodiazepenes Buspirone

Antipsychotics

Tricyclic

Compounds

(TCAs)

Range of effects

Mild sedation, d

to anxiolysis,

to hypnosis

as dose

increases

Calming

Reduce motor

activity

A variety

including

potent

antihistaminic

activity and

some sedation

Specific examples

Diazepam

Lorazepam

Midazolam

High

potency:

Alprazolam

Clorazepate

— Haloperidol Amitriptyline

Clomipramine

Imipramine

Disadvantages

Can interfere

with

learning and

affect

behavioral

modification

Delayed onset

of action

(2-4 wk)

See below

Delayed onset of

action (2-4 wk)

Potential adverse

effects

Sedation,

ataxia, d

paradoxical

excitation;

rare fatal

idiopathic

hepatic

necrosis in

cats given

diazepam PO

Few to mild;

confusion,

nausea,

anorexia

Extrapyramidal

signs: tremors,

dystonia,

dyskinesia or

akathisia;

transient

anorexia and

regurgitation

Anticholinergic

signs e

476

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