Exotic Animal Formulary5

Table 14-8
Antifungal Agents Used in Wild Mammals. a-c
Agent Dosage Species/Comments
Amphotericin B
0.25 mg/kg IV 3×/wk; maximum
dose 8 mg/kg; 4 mg/kg if
used with an azole 60
Carnivores/efficacy against aspergillosis
may be low; MIC indicated 77
Griseofulvin 1 mg/kg IV q24h 73 Rabbits, rodents
— Administer with fatty meal; may cause
bone marrow depression; monitor
CBC during treatment
25 mg/kg PO q12h or 50 mg/kg
PO q24h 60
Carnivores/dermatophytosis; continue
therapy 2 wk beyond clinical
resolution
25 mg/kg PO q24h×28 days 1,39 Rabbits, rodents, Virginia opossums,
eastern grey
squirrels/dermatophytosis
Itraconazole
(Itrafungol,
Elanco)
Nystatin
100,000 IU/mL
suspension
— Give with meal for most effective
absorption; monitor liver function
5-10 mg/kg PO q24h 38,67 Carnivores, rabbits
— Apply topically to oral lesions
5,000 IU/kg PO q8-12h 59 Opossums
50,000-150,000 IU topically
q6-8h 67
Carnivores/oral candidiasis
Terbinafine 8-20 mg/kg PO q24h 38 Rabbits
10-20 mg/kg PO q24h 67 Carnivores/dermatophytosis; can do
pulse therapy (7 days on, 21 days
off)
Voriconazole — Not recommended in felids due to
significant side effects
4 mg/kg PO q12h 67 Canids
a
Additional drug doses for other classes of wild animals may be found in other chapters of this
formulary.
b
“Carnivores” may include wild North American felids, canids, procyonids, ursids, and mustelids.
c
Many species of wildlife are hunted for human consumption. Drugs prohibited for use in food animals
should not be administered to these species if they will be released to the wild and/or consumed by
humans. See www.farad.org for list of drugs.
Table 14-9
897