Proceedings of the 10th International Colloquium on Paratuberculosis

More documents

Recommendations

Info

#74 Economic analysis <strong>of</strong> Johne’s disease control strategies for dairy herds Jaesung Cho, Loren W. Tauer, Rebecca L. Smith, Zhao Lu, Ynte H. Schukken, Yrjo T. Grohn Cornell University, USA Johne's Disease (JD) is a challenge to <strong>the</strong> dairy industry because <strong>of</strong> <strong>the</strong> pervasive economic loss it generates on dairy farms over extended periods <strong>of</strong> time. Effective control <strong>of</strong>ten requires years <strong>of</strong> diligent efforts. It is crucial for dairy producers to find economically optimal strategies for JD control that will reduce economic losses and <strong>the</strong>reby maximize pr<strong>of</strong>itability. The objective <strong>of</strong> this study was to determine <strong>the</strong> most economically optimal method for JD control. A discrete optimal control model was constructed to maximize Net Present Value (NPV) <strong>of</strong> a farm pr<strong>of</strong>it subject to economic and production constraints as well as equations <strong>of</strong> motion that model <strong>the</strong> dynamics <strong>of</strong> MAP transmission within <strong>the</strong> dairy herd. A GAMS/MINOS program was coded to empirically solve this model for optimal control strategies. Control strategies included test-based culling intervention with annual, semi-annual, and quarterly MAP testing, improved calf hygiene practices as well as <strong>of</strong>f-farm calf-rearing, both for a closed farm and an open farm. Control strategies were compared to determine <strong>the</strong> most effective method for JD control over <strong>the</strong> extended planning duration <strong>of</strong> a dairy farm. Parameters related to JD such as <strong>the</strong> rates <strong>of</strong> transition between JD states, and animal turnover in <strong>the</strong> dynamic model <strong>of</strong> MAP transmission, were both obtained from previous literature and ongoing research at Cornell. The model allows evaluation <strong>of</strong> effective controls by farm characteristics. Results show that control or elimination <strong>of</strong> Johne's disease at <strong>the</strong> farm level requires at least one <strong>of</strong> <strong>the</strong> JD control strategies, o<strong>the</strong>rwise <strong>the</strong> disease spreads unchecked through <strong>the</strong> herd. The most cost effective control depends upon economic parameters, which varies by farm and year. Control tactics <strong>of</strong>ten display interesting dynamics. Test and cull <strong>of</strong>ten produces a cyclical but damping pattern as calves become infected before diseased cows are identified and culled. 209
#79 Vaccination for Paratuberculosis in New Zealand farmed deer herds Peter Raymond Wilson, Lesley Stringer, Cord Heuer, Kathy Goodwin-Ray, Jaimie Hunnam, Colin Mackintosh, IVABS Massey University, Palmerston North, New Zealand; AgResearch Invermay, Mosgiel, New Zealand Aim: To evaluate Silirum ® in farmed deer. Method: Initial studies demonstrated 0.5, 1.0 and 2.0ml doses to three-month-old farmed red and red x wapiti deer (C. elaphus) were clinically safe, produced equivalent antibody and cellular immune responses, and caused few significant injection site lesions. Subsequently, six commercial deer farms previously reporting ≥5% annual incidence <strong>of</strong> clinical disease in young deer were selected for investigation <strong>of</strong> efficacy and crossreactivity with bovine tuberculosis tests. In March-April 2008, 180 - 1120 deer/farm were randomised to vaccination (0.5ml Silirum ® , n=1671) and control (n=1664) groups at 3.5 – 4.5 months <strong>of</strong> age, and managed toge<strong>the</strong>r on pasture. Clinical disease, mortality, weight and slaughter data were collected, and 25 vaccinated and control deer per farm faecal sampled for Map culture in November 2008. In January 2009, 180 vaccinated and 181 control deer from three farms underwent a comparative mid-cervical test (CCT) for bovine tuberculosis, also interpreted as a single mid-cervical test (MCT). Results: By May 2009 when 95% <strong>of</strong> deer had been slaughtered, disease had been diagnosed in nine vaccinated and 22 control deer on four farms, a tentative overall efficacy <strong>of</strong> 59% against clinical disease (p=0.02). Some injection site residual lesions were evident but did not affect carcass processing or value. Fifty nine (47%) vaccinates and 68 (55%) controls were faecal culture positive (p=0.2). Tuberculosis testing yielded 44% vaccinates and 23% controls MCT positive, respectively, and correspondingly, two and three were CCT positive. Two controls remained positive to an ancillary Elisa test. Final data will be presented. Conclusion: Despite <strong>the</strong> low incidence <strong>of</strong> clinical Ptb, <strong>the</strong>se data suggest that Silirum ® may aid control <strong>of</strong> clinical disease in young farmed deer. Fur<strong>the</strong>r data are now needed to better quantify efficacy. Tuberculin testing suggests that <strong>the</strong> risk <strong>of</strong> indistinguishable cross-reactivity is low in herds without tuberculosis. #83 Prevalence reducing factors in <strong>the</strong> Danish control programme on bovine paratuberculosis Søren Saxmose Nielsen, University <strong>of</strong> Copenhagen, Denmark A risk-based control programme on paratuberculosis in Danish dairy cattle was initiated in 2006. In total, 1265 herds (~28% <strong>of</strong> all dairy herds and ~40% <strong>of</strong> all dairy cows) were enrolled in <strong>the</strong> programme by April 2009. Cows are categorised as High-Risk or Low-Risk animals based on 3-4 annual milk antibody ELISA tests. High- Risk animals require management practices reducing calves exposure to milk and faeces from <strong>the</strong>se cows. Moreover, repeated test-positive cows are recommended to be slaughtered prior to next calving. The objective <strong>of</strong> this study was to assess <strong>the</strong> development in within-herd test-prevalences for different management practices. A questionnaire on management practices was distributed to all participating herds in January 2009. A total <strong>of</strong> 1075 (85%) herd-managers returned <strong>the</strong> questionnaire. Only <strong>the</strong> 679 herds that started in 2006 were included in <strong>the</strong> present analyses, because <strong>the</strong> effect <strong>of</strong> changes in management on prevalence would be expected at <strong>the</strong> earliest after 2 to 3 years. Results <strong>of</strong> univariable analyses showed that: a) culling <strong>of</strong> repeated test-positive cows reduced <strong>the</strong> testprevalence by 7%-points; b) cleaning <strong>of</strong> calving area subsequent to High-Risk cows’ calvings led to a reduction <strong>of</strong> 3%-points; c) separation <strong>of</strong> High-Risk animals from Low-Risk animals resulted in a reduction <strong>of</strong> 2%-points; and d) use <strong>of</strong> colostrum from Low-Risk animals only, resulted in a reduction <strong>of</strong> 1.5%-points. Feeding practices using milk from High-Risk cows did not reduce <strong>the</strong> prevalence. The control programme has been running for ~3 years in <strong>the</strong> herds included, and it is assumed that <strong>the</strong> full effect will only be observed after 4-8 years. However, already after 3 years, reduced prevalences were observed due to changes in specific management practices. The reductions are not additive due to possible confounding, which could not be assessed at this point in time because <strong>of</strong> <strong>the</strong> distribution <strong>of</strong> management factors. 210
Page 1 and 2:
Book of Abstracts
Page 4 and 5:
Proceedings <stron
Page 6 and 7:
Grant Support and Sponsorship <stro
Page 8 and 9:
Scott Wells - Planning Committee Ch
Page 10 and 11:
Monday, August 10, 2009 - All sessi
Page 12 and 13:
Kari Røste Lybeck, Anne Kristine S
Page 14 and 15:
1120-1140 #88: Influence of
Page 16 and 17:
Concurrent Session B - Rm 175 Wille
Page 18 and 19:
Thursday, August 13 Thursday, Augus
Page 20:
Diagnostics and Genotyping Convenor
Page 23 and 24:
#229 Detecting Johne’s Disease he
Page 25 and 26:
Kalis CHJ, Hesselink JW, Barkema HW
Page 27 and 28:
MATERIALS AND METHODS Sampling For
Page 29 and 30:
To better determine the</st
Page 31 and 32:
#107 Multilocus Short Sequence Repe
Page 33 and 34:
Fig. 1. Dendogram (showing genetic
Page 35 and 36:
#105 MIRU-VNTR genotyping o
Page 37:
Diagnostics and Genotyping Poster A
Page 40 and 41:
Missouri). Serum from a cow with do
Page 42 and 43:
#7 Significance of
Page 44 and 45:
RESULTS Of the 327
Page 46 and 47:
Direct fecal nested Map PCR testing
Page 48 and 49:
#16 Histopathological and immunohis
Page 50 and 51:
#19 Development of
Page 52 and 53:
#36 Genetic diversity of</s
Page 54 and 55:
#60 Evaluation of
Page 56 and 57:
#66 Comparison of
Page 58 and 59:
(b) IS900 Nested PCR, using p90-p91
Page 60 and 61:
(d) f57 Real Time PCR. The figure o
Page 62 and 63:
• MIRU (3 loci); • VNTR-MIRU (7
Page 64 and 65:
indexes, compared to each single an
Page 66 and 67:
#108 Evaluation of
Page 68 and 69:
#110 Detection and molecular confir
Page 70 and 71:
endoscopic criteria and histopathol
Page 72 and 73:
Bull TJ, McMinn EJ, Sidi-Boumedine
Page 74 and 75:
#131 Seroprevalence of</str
Page 76 and 77:
could be partly attributed to a sma
Page 78 and 79:
#146 Analysis of v
Page 80 and 81:
#162 Comparison of
Page 82 and 83:
#187 Comparison of
Page 84 and 85:
#191 Potentiating day-old blood sam
Page 86 and 87:
samples from the s
Page 88 and 89:
(MAA) (MAP87 and MAP3776) and 1 fro
Page 90 and 91:
#196 Inter- and intra-subtype genot
Page 92 and 93:
RESULTS In 601 (29%) of</st
Page 94 and 95:
#211 Culture of my
Page 96 and 97:
#242 Application and field validati
Page 98 and 99:
#251 Diagnosis of
Page 100 and 101:
Table 2. Paratuberculosis PCR resul
Page 102 and 103:
#254 Programmes on Paratuberculosis
Page 104 and 105:
Fig. 1. European countries specifyi
Page 106 and 107:
A bulk milk quality assurance progr
Page 108 and 109:
Republic of Lithua
Page 110 and 111:
#276 Elimination of</strong
Page 112 and 113:
other projects and
Page 114 and 115:
Woodbine KA, Schukken YH, Green LE,
Page 116 and 117:
Host Response and Immunology Keynot
Page 118 and 119:
#33 MERKAL AWARD LECTURE No interfe
Page 120 and 121:
#75 Interleukin 17 and interleukin
Page 122 and 123:
#173 Local and systemic roles for b
Page 124 and 125:
#23 Role of Mycoba
Page 126 and 127:
Host Response and Immunology Poster
Page 128 and 129:
#28 Intestinal MAP Infection via Pe
Page 130 and 131:
#73 Age susceptibility of</
Page 132 and 133:
#95 Role of nitric
Page 134 and 135:
#134 Analysis of <
Page 136 and 137:
#157 Study of <str
Page 138 and 139:
#163 Immunohistochemical expression
Page 140 and 141:
#193 Development of</strong
Page 142 and 143:
#209 Murine macrophages carrying an
Page 144 and 145:
#224 Application of</strong
Page 146 and 147:
Table 1 UK and Cyprus MAP survey Re
Page 148 and 149:
#228 Mycobacterium avium ssp. parat
Page 150 and 151:
#145 MERKAL AWARD LECTURE Multinomi
Page 152 and 153:
#50 Assessment of
Page 154 and 155:
Table 1. Posterior median (CrIs) <s
Page 156 and 157:
#55 Birth clusters of</stro
Page 158 and 159:
from their dam, se
Page 160 and 161: #88 Influence of b
Page 162 and 163: #104 Relation between faecal shedde
Page 164 and 165: Epidemiology Poster Abstracts 109 1
Page 166 and 167: #22 The Prevalence of</stro
Page 168 and 169: CONCLUSION IS1311-based nested Ma/M
Page 170 and 171: #42 Seroprevalence survey o
Page 172 and 173: #77 Characterisation of</st
Page 174 and 175: Environmental samples were collecte
Page 176 and 177: REFERENCES 1) Chiodini RJ, Van Krui
Page 178 and 179: #113 Effect of soi
Page 180 and 181: #136 Error-adjusted, variance parti
Page 182 and 183: Latium Region Viterbo districts RES
Page 184 and 185: #144 The suitability of</st
Page 186 and 187: #178 Age structure of</stro
Page 188 and 189: A statistically significant lower f
Page 190 and 191: #183 Sero-prevalence of</st
Page 192 and 193: #218 Johne’s disease in t
Page 194 and 195: #244 A survey to estimate t
Page 196 and 197: Control Programs Keynote Lecture Re
Page 198 and 199: #202 Milk quality assurance for par
Page 200 and 201: #141 Control of pa
Page 202 and 203: #198 Use of small
Page 204 and 205: Control Programs Poster Abstracts 1
Page 206 and 207: RESULTS Loss of al
Page 208 and 209: #40 Managing Bovine Johnes Disease
Page 212 and 213: #87 Evaluation of
Page 214 and 215: separately for each existing herd <
Page 216 and 217: #98 An inter-laboratory ring-trial
Page 218 and 219: #120 Paratuberculosis vaccine inter
Page 220 and 221: The statement provides: • A stand
Page 222 and 223: COMPLEMENTARY ASPECTS On-Farm Disea
Page 224 and 225: #168 Paratuberculosis in Iran: past
Page 226 and 227: #180 Behavioural change in owners <
Page 228 and 229: the fact that <str
Page 230 and 231: #182 An integrated risk based appro
Page 232 and 233: etween 0 to 10, depending on <stron
Page 234 and 235: #203 Milk quality assurance for par
Page 236 and 237: #234 Johne’s disease vaccine: a c
Page 238 and 239: Pathogenomics and MAP Biology Conve
Page 240 and 241: #45 Identification of</stro
Page 242 and 243: #117 Adsorption of
Page 244 and 245: #222 Atypical structural features <
Page 246 and 247: Pathogenomics and MAP Biology Persp
Page 248 and 249: 247
Page 250 and 251: #52 Is ‘Indian Bison Type’ Myco
Page 252 and 253: #69 In vitro susceptibility <strong
Page 254 and 255: #118 Cloning, expression and purifi
Page 256 and 257: #176 A reference proteomic pr<stron
Page 258 and 259: #213 Construction the</stro
Page 260 and 261:
#230 Iron concentration dependent s
Page 262 and 263:
261
Page 264 and 265:
263
Page 266 and 267:
Abstract not available at press tim
Page 268 and 269:
#174 Sharing of
Page 270 and 271:
#177 Associations between CARD15 po
Page 272 and 273:
Perspectives Talk: Public Health My
Page 274 and 275:
273
Page 276 and 277:
A total of 206 qua
Page 278 and 279:
Feller, M., K. Huwiler, R. Stephan,
Page 280 and 281:
In 2008, the Ameri
Page 282 and 283:
#115 Crohn’s disease and ruminant
Page 284 and 285:
International John
Page 286 and 287:
#76 Towards improved reporting stan
Page 288 and 289:
#97 The EU ParaTBTools Project - Th
Page 290 and 291:
#241 US Vaccine Initiative through
Page 292 and 293:
Paratuberculosis ELISA Reliable, si
Page 294 and 295:
PRIONICS AG WAGISTRASSE 27A PHONE +
show all

Proceedings of the 10th International Colloquium on Paratuberculosis

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?