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Proceedings of the 10th International Colloquium on Paratuberculosis

Proceedings of the 10th International Colloquium on Paratuberculosis

Proceedings of the 10th International Colloquium on Paratuberculosis

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The aim <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>the</str<strong>on</strong>g> present study was to evaluate <str<strong>on</strong>g>the</str<strong>on</strong>g> surveillance system regarding MAP in<br />

Swedish cattle, to quantify <str<strong>on</strong>g>the</str<strong>on</strong>g> c<strong>on</strong>tributi<strong>on</strong> from different surveillance comp<strong>on</strong>ents and to<br />

estimate <str<strong>on</strong>g>the</str<strong>on</strong>g> probability that Swedish cattle are free from MAP.<br />

MATERIALS AND METHODS<br />

A stochastic scenario-tree model was used to estimate <str<strong>on</strong>g>the</str<strong>on</strong>g> probability <str<strong>on</strong>g>of</str<strong>on</strong>g> freedom from MAP<br />

infecti<strong>on</strong>. This method has previously been described by Martin and co-workers (Martin et al.,<br />

2007a; Martin et al., 2007b) and allows informati<strong>on</strong> from several different sources, e.g.<br />

random or n<strong>on</strong>-random surveillance data as well as documentati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> differences in risk, to<br />

c<strong>on</strong>tribute to <str<strong>on</strong>g>the</str<strong>on</strong>g> quantitative estimati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> surveillance sensitivities and probability <str<strong>on</strong>g>of</str<strong>on</strong>g><br />

disease. In this type <str<strong>on</strong>g>of</str<strong>on</strong>g> model, factors relating to <str<strong>on</strong>g>the</str<strong>on</strong>g> structure <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>the</str<strong>on</strong>g> study populati<strong>on</strong> and to<br />

<str<strong>on</strong>g>the</str<strong>on</strong>g> probability <str<strong>on</strong>g>of</str<strong>on</strong>g> detecti<strong>on</strong>, or infecti<strong>on</strong>, are included as nodes for which input proporti<strong>on</strong>s or<br />

probabilities are given. One example <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>the</str<strong>on</strong>g> tree-like structure <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>the</str<strong>on</strong>g> model is given in Fig. 1<br />

which shows <str<strong>on</strong>g>the</str<strong>on</strong>g> risk categories and relevant detecti<strong>on</strong> pathways relating to paratuberculosis<br />

investigati<strong>on</strong>s in fallen stock.<br />

Figure 1. Structure <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>the</str<strong>on</strong>g> scenario-tree model for evaluati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> MAP surveillance in Sweden.<br />

This example illustrates <str<strong>on</strong>g>the</str<strong>on</strong>g> surveillance comp<strong>on</strong>ent covering investigati<strong>on</strong>s <str<strong>on</strong>g>of</str<strong>on</strong>g> fallen stock.<br />

Empty arrows indicate corresp<strong>on</strong>ding branches.<br />

In brief, <str<strong>on</strong>g>the</str<strong>on</strong>g> scenario-tree model is used to calculate <str<strong>on</strong>g>the</str<strong>on</strong>g> probability <str<strong>on</strong>g>of</str<strong>on</strong>g> freedom based <strong>on</strong> <str<strong>on</strong>g>the</str<strong>on</strong>g><br />

different probabilities <str<strong>on</strong>g>of</str<strong>on</strong>g> detecting each type <str<strong>on</strong>g>of</str<strong>on</strong>g> infected unit, in case infecti<strong>on</strong> is present in <str<strong>on</strong>g>the</str<strong>on</strong>g><br />

populati<strong>on</strong>. By this approach more weight is given to investigati<strong>on</strong>s in herds and animal <str<strong>on</strong>g>of</str<strong>on</strong>g><br />

known risk categories.<br />

The probability <str<strong>on</strong>g>of</str<strong>on</strong>g> detecti<strong>on</strong> at <str<strong>on</strong>g>the</str<strong>on</strong>g> animal level, i.e. <str<strong>on</strong>g>the</str<strong>on</strong>g> animal-level sensitivity, is used<br />

to calculate <str<strong>on</strong>g>the</str<strong>on</strong>g> herd-level sensitivity. In our model, <str<strong>on</strong>g>the</str<strong>on</strong>g> herd sensitivity was calculated<br />

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