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Proceedings of the 10th International Colloquium on Paratuberculosis

Proceedings of the 10th International Colloquium on Paratuberculosis

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In 2008, <str<strong>on</strong>g>the</str<strong>on</strong>g> American Academy <str<strong>on</strong>g>of</str<strong>on</strong>g> Microbiologists published its report <strong>on</strong> Mycobacterium<br />

avium paratuberculosis: Infrequent human pathogen or public health threat (2). The<br />

executive summary states, “<str<strong>on</strong>g>the</str<strong>on</strong>g> associati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> MAP and CD is no l<strong>on</strong>ger in questi<strong>on</strong>. The<br />

critical issue today is not whe<str<strong>on</strong>g>the</str<strong>on</strong>g>r MAP is associated with CD, but whe<str<strong>on</strong>g>the</str<strong>on</strong>g>r MAP causes CD<br />

or is <strong>on</strong>ly incidentally present.”<br />

By 2008, <str<strong>on</strong>g>the</str<strong>on</strong>g> majority <str<strong>on</strong>g>of</str<strong>on</strong>g> Koch’s postulates for causati<strong>on</strong> had been effectively met from data<br />

engendered by <str<strong>on</strong>g>the</str<strong>on</strong>g> medical side <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>the</str<strong>on</strong>g> c<strong>on</strong>troversy (3-9).<br />

In 2009, three independent diagnostic laboratories (Michael T. Collins, Saleh A. Naser, and<br />

that <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>the</str<strong>on</strong>g> Centers for Disease C<strong>on</strong>trol and Preventi<strong>on</strong>) recovered Map from <str<strong>on</strong>g>the</str<strong>on</strong>g> blood <str<strong>on</strong>g>of</str<strong>on</strong>g><br />

individuals with Crohn’s disease (10). Naser’s previous recovery <str<strong>on</strong>g>of</str<strong>on</strong>g> Map from <str<strong>on</strong>g>the</str<strong>on</strong>g> blood <str<strong>on</strong>g>of</str<strong>on</strong>g><br />

Crohn’s patients and <str<strong>on</strong>g>the</str<strong>on</strong>g> breast milk <str<strong>on</strong>g>of</str<strong>on</strong>g> two postpartum CD females without corresp<strong>on</strong>ding<br />

recovery from n<strong>on</strong>-Crohn’s diseased individuals had been largely under appreciated.<br />

CONCLUSION<br />

From a medical infectious disease point <str<strong>on</strong>g>of</str<strong>on</strong>g> view, <str<strong>on</strong>g>the</str<strong>on</strong>g> validati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> Naser’s original findings<br />

cuts short <str<strong>on</strong>g>the</str<strong>on</strong>g> argument as to causality. If an individual has certain retroviruses in his or her<br />

white blood cells, he or she has HIV infecti<strong>on</strong>. If <str<strong>on</strong>g>the</str<strong>on</strong>g> individual has hepatitis B or C virus in his<br />

or her white blood cells, he or she has hepatitis infecti<strong>on</strong>. If an individual has Map in his or<br />

her white blood cells, he or she has infecti<strong>on</strong> with map. If <str<strong>on</strong>g>the</str<strong>on</strong>g> vast prep<strong>on</strong>derance <str<strong>on</strong>g>of</str<strong>on</strong>g><br />

individuals with map in <str<strong>on</strong>g>the</str<strong>on</strong>g>ir white blood cells has Crohn’s disease or irritable bowel<br />

syndrome, <str<strong>on</strong>g>the</str<strong>on</strong>g> critical element <str<strong>on</strong>g>of</str<strong>on</strong>g> Koch’s postulates for causati<strong>on</strong> has been met.<br />

The Rio Declarati<strong>on</strong> Relative to Food Safety states, “Where <str<strong>on</strong>g>the</str<strong>on</strong>g>re are threats <str<strong>on</strong>g>of</str<strong>on</strong>g> irreversible<br />

damage, lack <str<strong>on</strong>g>of</str<strong>on</strong>g> full scientific certainty shall not be used as reas<strong>on</strong> to postp<strong>on</strong>e cost-effective<br />

measures to prevent envir<strong>on</strong>mental degradati<strong>on</strong>.”<br />

REFERENCES<br />

1. Rubery E.: A review <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>the</str<strong>on</strong>g> evidence for a link between Mycobacterium paratuberculosis<br />

(MAP) and Crohn’s disease (CD) in humans: A report for <str<strong>on</strong>g>the</str<strong>on</strong>g> Food Standard Agency,<br />

June 1 2001.<br />

2. Nacy C. Buckley M.: Mycobacterium avium paratuberculosis: Infrequent human<br />

pathogen or public health threat? Report from <str<strong>on</strong>g>the</str<strong>on</strong>g> American Academy <str<strong>on</strong>g>of</str<strong>on</strong>g> Microbiology<br />

2008. p. 1-37.<br />

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Mycobacterium avium subspecies paratuberculosis in fresh ileocol<strong>on</strong>ic mucosal biopsies<br />

from individuals with and without Crohn’s disease. J. Clin. Micro. 2003; 41:2915-2923.<br />

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paratuberculosis infecti<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> irritable bowel syndrome and comparis<strong>on</strong> with Crohn’s<br />

disease and Johne’s disease: comm<strong>on</strong> neural and immune pathogenicities. J. Clin.<br />

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paratuberculosis (MAP) from breast milk <str<strong>on</strong>g>of</str<strong>on</strong>g> patients with Crohn’s disease. Am. J.<br />

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6. Naser S.A., Ghobrial G., Romero C., Valentine J. F.: Culture <str<strong>on</strong>g>of</str<strong>on</strong>g> Mycobacterium avium<br />

subspecies paratuberculosis (MAP) from <str<strong>on</strong>g>the</str<strong>on</strong>g> blood <str<strong>on</strong>g>of</str<strong>on</strong>g> Crohn’s disease patients. Lancet<br />

2004; 364:1039-1044.<br />

7. Sechi L. A., Scanu A. M., Molicotti P., Molicotti P., Cannes S., Mura M., Dettori G.,<br />

Fadda G., Zanetti S.: Detecti<strong>on</strong> and isolati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> Mycobacterium avium subspecies<br />

paratuberculosis from intestinal biopsies <str<strong>on</strong>g>of</str<strong>on</strong>g> patients with and without Crohn’s disease in<br />

Sardinia. Am. J. Gastroenteriol. 2005; 100:1529-1534.<br />

8. Autschback F., Eisold S., Hinz U.: High prevalence <str<strong>on</strong>g>of</str<strong>on</strong>g> Mycobacterium avium subspecies<br />

paratuberculosis IS900 DNA in gut tissue from individuals with Crohn’s disease. Gut<br />

2005; 54:944-949.<br />

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