Monograph on the Potential Human Reproductive and ... - OEHHA

BISPHENOL A
Table 14
Summary of Food or Aggregate Exposures to Bisphenol A
Exposure
estimate mg/kg
Population Basis of estimates bw/day a
Reference
1–2-month-old infant Food exposure (data from migration studies of 8 European Union (2003)
polycarbonate bottles)
0–4-month-old infant Food exposure (data from migration studies of 1.6 European Commission
polycarbonate bottles) (2002)
0–5-month-old infant Aggregate exposure (based on formula, 0.055 Miyamoto and Kotake
(formula-fed) environmental, and toy exposures) (2006)
0–5-month-old infant Aggregate exposure (based on human milk, 0.028 Miyamoto and Kotake
(breast fed) environmental, and toy exposures) (2006)
4–6-month-old infant Food exposure (data from migration studies of 7 European Union (2003)
polycarbonate bottles)
6–11-month-old infant Aggregate exposure (based on formula, food, 0.18 Miyamoto and Kotake
(formula-fed) environmental, and toy exposures) (2006)
6–11-month-old infant Aggregate exposure (based on human milk, food, 0.16 Miyamoto and Kotake
(breast-fed) environmental, and toy exposures) (2006)
6–12-month-old infant Food exposure (data from survey of canned foods) 5 European Union (2003)
6–12-month-old infant Food exposure (data from migration studies with 1.65 European Commission
infant bottles and canned foods) (2002)
Infant Food exposure (data from polycarbonate bottle 0.75–1 Earls (2000)
leaching studies)
Infant Food exposures (contact with cans and 1.75 FDA (1996)
polycarbonate plastics)
1.5–4.5-year-old child Food exposure (data from survey of canned foods 14.7 European Union (2003)
and migration studies with polycarbonate
tableware)
1–6-year-old child Aggregate exposure (based on food, environmental, 1.2 Miyamoto and Kotake
and tableware exposures) (2006)
1.5–5 year old child Aggregate exposure (surveys of bisphenol in food, 0.06-0.07 Wilson et al. (2006)
air, dust, soil and hand and surface wipes) (0.03–1.57)
3–5-year-old child Aggregate exposure (surveys of bisphenol in food, 0.04 Wilson et al. (2003)
air, dust, and soil) (0.018–0.07)
2–6-year-old child Food exposure (collection of 200 food items) 0.004 Miyamoto and Kotake
(2006)
4–6-year-old child Food exposure (data from survey of canned foods) 1.2 European Commission
(2002)
7–14-year-old child Aggregate exposure (based on food, environmental, 0.55 Miyamoto and Kotake
and tableware exposures) (2006)
15–19-year-old individual Aggregate exposure (based on food, environmental, 0.36 Miyamoto and Kotake
and tableware exposures) (2006)
Adult, Z19 years Aggregate exposure (based on food, environmental, 0.43 Miyamoto and Kotake
and tableware exposures) (2006)
Adult Food exposure (data from survey of canned foods 1.4 European Union (2003)
not including wine)
Adult Food exposure (data from surveys of canned food) 0.37 European Commission
(2002)
Adult Wine exposure (data from study of epoxy-lined wine 0.11 European Commission
drums) (2002)
Adult Wine exposure (data from wine samples) o0.026 Brenn-Struckhofova and
Cichna-Markel (2006)
Adult Food exposure (from contact with epoxy-lined cans 0.183 FDA (1996)
and polycarbonate)
Adults Food exposure (survey of canned foods) 0.008 Thomson and Grounds
(2005)
Adult Food exposure (collection of 200 food items) 0.002 Miyamoto and Kotake
(2006)
a Estimates involving extreme worst case scenarios and Japanese data with very limited information were not included in this table.
American Industrial Hygiene Association proposed a value is consistent with the time weighted average
workplace environmental exposure level (WEEL) of (TWA) exposure limits established in Germany and the
5 mg/m 3 for bisphenol A. The draft WEEL was based Netherlands (European-Union, 2003).
on irritation observed in an inhalation toxicity study The European Union (2003) summarized occupational
(American Industrial Hygiene Association, 2004). The exposure data for bisphenol A in Europe and the U.S.
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