Monograph on the Potential Human Reproductive and ... - OEHHA

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nTp brief 240..Parry. EM,. Parry. JM,. Corso. C,. Doherty. A,. Haddad. F,. Hermine. TF,. Johnson. G,. Kayani.M,.Quick.E,.Warr.T,.Williamson.J. (2002).Mutagenesis..Detection.and.characterization.of.mechanisms.of.action.of. aneugenic.chemicals..17:509.–.521. 241..Lenie.S,.Cortvrindt.R,.Eichenlaub-Ritter. U,.Smitz.J.(2008).Mutat Res..Continuous. exposure.to.bisphenol.A.during.in vitro follicular. development. induces. meiotic. abnormalities..651:71.–.81. 242..Quick. EL,. Parry. EM,. Parry. JM. (2008). Mutat Res..Do.oestrogens.induce.chromosome.specific.aneuploidy.in.vitro,.similar. to.the.pattern.of.aneuploidy.seen.in.breast. cancer?.651:46.–.55. 243..Johnson.GE,.Parry.EM.(2008).Mutat Res.. Mechanistic.investigations.of.low.dose.exposures.to.the.genotoxic.compounds.bisphenol-A.and.rotenone..651:56.–.63. 244..George.O,.Bryant.BK,.Chinnasamy.R,.Corona.C,.Arterburn.JB,.Shuster.CB.(2008). ACS Chem Biol..Bisphenol.A.directly.targets. tubulin. to. disrupt. spindle. organization.in.embryonic.and.somatic.cells..3:. 167.–.179. 245..Al-Hiyasat. AS,. Darmani. H,. Elbetieha. AM.(2004).Eur J Oral Sci..Leached.components.from.dental.composites.and.their. effects. on. fertility. of. female. mice.. 112:. 267.–.272. 246..Coughtrie. MW,. Burchell. B,. Leakey. JE,. Hume.R.(1988).Mol Pharmacol..The.inadequacy. of. perinatal. glucuronidation:. immunoblot.analysis.of.the.developmental. expression.of.individual.UDP-glucuronosyltransferase.isoenzymes.in.rat.and.human.liver.microsomes..34:729.–.735. 63 247..Strassburg.CP,.Strassburg.A,.Kneip.S,.Barut.A,.Tukey. RH,. Rodeck. B,. Manns. MP. (2002).Gut..Developmental.aspects.of.human.hepatic.drug.glucuronidation.in.young. children.and.adults..50:259.–.265. 248..Cappiello.M,.Giuliani.L,.Rane.A,.Pacifici. GM.(2000).Eur J Drug Metab Pharmacokinet.. Uridine. 5’-.diphosphoglucuronic. acid. (UDPGLcUA). in. the. human. fetal. liver,.kidney.and.placenta..25:161.–.163. 249..Shin.BS,.Kim.CH,.Jun.YS,.Kim.DH,.Lee. BM,.Yoon. CH,. Park. EH,. Lee. KC,. Han. SY,.Park.KL,.Kim.HS,.Yoo.SD.(2004).J Toxicol Environ Health A..Physiologically. based. pharmacokinetics. of. bisphenol.A.. 67:1971.–.1985. 250..Tsukioka.T,.Terasawa,.J.,.Sato,.S.,.Hatayama,.Y.,.Makino,.T.,.and.Nakazawa,.H.. 2004.(2004).J Environ Chem..Development. of.analytical.method.of.determining.trace. amount. of. bisphenol.A. in. urine. samples. and.estimation.of.exposure.to.bisphenol.A.. 14:57.–.63. 251..Brock.JW,.Yoshimura.Y,.Barr.JR,.Maggio. VL,. Graiser. SR,. Nakazawa. H,. Needham. LL.(2001).J Expo Anal Environ Epidemiol.. Measurement.of.bisphenol.A.levels.in.human.urine..11:323.–.328. 252..Völkel.W,.Colnot.T,.Csanady.GA,.Filser. JG,.Dekant.W.(2002).Chem Res Toxicol.. Metabolism. and. kinetics. of. bisphenol.A. in.humans.at.low.doses.following.oral.administration..15:1281.–.1287. 253..Ye.X,.Kuklenyik.Z,.Needham.LL,.Calafat. AM.(2005).Anal Bioanal Chem..Quantification.of.urinary.conjugates.of.bisphenol.A,.2,5-dichlorophenol,.and.2-hydroxy-4-methoxybenzophenone. in. humans. by. online.
solid.phase.extraction-high.performance. liquid.chromatography-tandem.mass.spectrometry..383:638.–.644. 254..Ye. X,. Bishop.AM,. Reidy. JA,. Needham. LL,.Calafat.AM.(2007).J Expo Sci Environ Epidemiol..Temporal. stability. of. the. conjugated.species.of.bisphenol.A,.parabens,.and.other.environmental.phenols.in. human.urine..17:567.–.572. 255..Ye.X,.Bishop.AM,.Needham.LL,.Calafat. AM.(2008).Anal Chim Acta..Automated. on-line.column-switching.HPLC-MS/MS. method. with. peak. focusing. for. measuring. parabens,. triclosan,. and. other. environmental. phenols. in. human. milk.. 622:. 150.–.156. 256..Ye.X,.Tao.LJ,.Needham.LL,.Calafat.AM. (2008). Talanta..Automated. on-line. column-switching. HPLC-MS/MS. method. for.measuring.environmental.phenols.and. parabens.in.serum..76:865.–.871. 257..Upmeier.A,. Degen. GH,. Diel. P,. Michna. H,.Bolt.HM.(2000).Arch Toxicol..Toxicokinetics.of.bisphenol.A.in.female.DA/Han. 64 rats.after.a.single.i.v..and.oral.administration..74:431.–.436. 258..Tominaga.T,.Negishi.T,.Hirooka.H,.Miyachi.A,. Inoue.A,. Hayasaka. I,.Yoshikawa. Y. (2006). Toxicology.. Toxicokinetics. of. bisphenol.A. in. rats,. monkeys. and. chimpanzees.by.the.LC-MS/MS.method..226:. 208.–.217. 259..Lucier.GW,.Portier.CJ,.Gallo.MA.(1993). Environ Health Perspect..Receptor.mechanisms.and.dose-response.models.for.the. effects.of.dioxins..101:36.–.44. 260.. Welshons.WV,.Thayer.KA,.Judy.BM,.Taylor. JA,. Curran. EM,. vom. Saal. FS. (2003). Environ Health Perspect.. Large. effects. from.small.exposures..I..Mechanisms.for. endocrine-disrupting.chemicals.with.estrogenic.activity..111:994.–.1006. 261..Völkel. W,. Bittner. N,. Dekant. W. (2005). Drug Metab Dispos..Quantitation.of.bisphenol.A.and.bisphenol.A.glucuronide.in. biological.samples.by.high.performance. liquid.chromatography-tandem.mass.spectrometry..33:1748.–.1757. nTp brief
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National Toxicology Program U.S. De
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[This page inTenTionally lefT blank
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NTP.will.transmit.the.NTP-CERHR.<st
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National Toxicology Program U.S. De
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nTp brief tainers.with.internal.epo
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Population Adult General. Populatio
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Table 3. Blood and Breast Milk Biom
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Figure 2b. The weight of evidence t
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in.considering.the.biological.plaus
Page 25 and 26: isphenol.A.as.efficiently.as.adult.
Page 27 and 28: isphenol.A..For.example,.this.raise
Page 29 and 30: laboRaToRy aNImal STudIeS In.contra
Page 31 and 32: of.normal.sex-based.differences.bet
Page 33 and 34: death.(168),.synaptic.plasticity.(1
Page 35 and 36: gland.carcinogen.or.that.bisphenol.
Page 37 and 38: understand.the.possible.long-term.c
Page 39 and 40: strategies.to.improve.the.sensitivi
Page 41 and 42: • • Howdeshell.et.al. (55).repo
Page 43 and 44: and.cystic.endometrial.hyperplasia.
Page 45 and 46: cutaneous. injection. 20 . vom. Saa
Page 47 and 48: are CurrenT exposures To bisphenol
Page 49 and 50: w/day;.95th.percentiles.0.289.-.0.2
Page 51 and 52: nTp ConClusions The.NTP.reached.the
Page 53 and 54: appendix a: inTerpreTaTion of blood
Page 55 and 56: µg/kg.bw/day.based.on.the.assumpti
Page 57 and 58: concentrations.from.maternal,.fetal
Page 59 and 60: 12.. Padmanabhan. V,. Siefert. K,.
Page 61 and 62: In..Research.Triangle.Park,.NC:.RTI
Page 63 and 64: 65.. Alonso-Magdalena. P,. Laribi.
Page 65 and 66: 91.. Calabrese.EJ,.Baldwin.LA.(2003
Page 67 and 68: Thyroid.Function.in.Juvenile.Female
Page 69 and 70: droxylase.immunoreactivity..76:423.
Page 71 and 72: stanceschimiques.gc.ca/challenge-de
Page 73 and 74: Watanabe.H,.Ohta.Y,.Iguchi.T.(2006)
Page 75: 226..vom. Saal. FS,. Cooke. PS,. Bu
Page 79 and 80: appendix i. nTp-Cerhr bisphenol a e
Page 81 and 82: 158 CHAPIN ET AL. the CERHR Core Co
Page 83 and 84: 160 CHAPIN ET AL. referred to as 4,
Page 85 and 86: 162 CHAPIN ET AL. concentrations in
Page 87 and 88: 164 CHAPIN ET AL. Food (no. sampled
Page 89 and 90: 166 CHAPIN ET AL. Table 6 Continued
Page 91 and 92: 168 CHAPIN ET AL. comparison of the
Page 93 and 94: 170 CHAPIN ET AL. Table 8 Urinary C
Page 95 and 96: 172 CHAPIN ET AL. the blood of male
Page 97 and 98: 174 CHAPIN ET AL. Table 11 Bispheno
Page 99 and 100: 176 CHAPIN ET AL. Table 13 Summarie
Page 101 and 102: 178 CHAPIN ET AL. Table 15 Estimate
Page 103 and 104: 180 CHAPIN ET AL. Table 17 Maximum
Page 105 and 106: 182 CHAPIN ET AL. 2.0 GENERAL TOXIC
Page 107 and 108: 184 CHAPIN ET AL. fetuses (3.572.7
Page 109 and 110: 186 CHAPIN ET AL. Secondary sources
Page 111 and 112: 188 CHAPIN ET AL. Table 25 Maternal
Page 113 and 114: 190 CHAPIN ET AL. Table 27 Bispheno
Page 115 and 116: 192 CHAPIN ET AL. Table 31 Qualitat
Page 117 and 118: 194 CHAPIN ET AL. Table 33 Toxicoki
Page 119 and 120: 196 CHAPIN ET AL. Table 36 Toxicoki
Page 121 and 122: 198 CHAPIN ET AL. appeared to occur
Page 123 and 124: 200 CHAPIN ET AL. Table 43 Biliary
Page 125 and 126: 202 CHAPIN ET AL. suggesting that 4
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204 CHAPIN ET AL. low following ora
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206 CHAPIN ET AL. scaling and speci
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208 CHAPIN ET AL. 60-100% in each d
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210 CHAPIN ET AL. related. No histo
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212 CHAPIN ET AL. Table 52 Continue
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214 CHAPIN ET AL. Model and exposur
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216 CHAPIN ET AL. Model and exposur
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218 Model and exposure Husbandry a
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220 CHAPIN ET AL. Table 54 Differen
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222 CHAPIN ET AL. Table 56 Anti-And
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224 Table 57 In Vitro Genetic Toxic
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226 CHAPIN ET AL. Table 58 In Vivo
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228 CHAPIN ET AL. Table 59 Developm
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230 CHAPIN ET AL. Table 62 Toxicoki
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232 CHAPIN ET AL. Table 64 Tissue R
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234 CHAPIN ET AL. Table 68 Toxicoki
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236 CHAPIN ET AL. treatment conditi
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238 CHAPIN ET AL. clinical signs, b
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240 CHAPIN ET AL. Table 71 Benchmar
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242 CHAPIN ET AL. group, 5 from 1 l
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244 CHAPIN ET AL. least significant
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246 CHAPIN ET AL. group was a reduc
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248 CHAPIN ET AL. 100-151 g for fem
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250 CHAPIN ET AL. 3.2.3.2 Developme
Page 175 and 176:
252 CHAPIN ET AL. weights, bispheno
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254 CHAPIN ET AL. 120 mg/kg bw/day
Page 179 and 180:
256 CHAPIN ET AL. comparisons condu
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258 CHAPIN ET AL. the findings of t
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260 CHAPIN ET AL. analyzed.] Anogen
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262 CHAPIN ET AL. purposeful confou
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264 CHAPIN ET AL. increased lordosi
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266 CHAPIN ET AL. that there was a
Page 191 and 192:
268 CHAPIN ET AL. duration of adver
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270 CHAPIN ET AL. doses of potent e
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272 CHAPIN ET AL. Table 74 Effects
Page 197 and 198:
274 CHAPIN ET AL. reproductive orga
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276 CHAPIN ET AL. tyrosine-hydroxly
Page 201 and 202:
278 CHAPIN ET AL. include small sam
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280 CHAPIN ET AL. males/group. [It
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282 CHAPIN ET AL. termination, whic
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284 CHAPIN ET AL. provided a reliab
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286 CHAPIN ET AL. grooming, and out
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288 CHAPIN ET AL. method of oral do
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290 CHAPIN ET AL. reared by their d
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292 CHAPIN ET AL. has been informed
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294 CHAPIN ET AL. buffered paraform
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296 CHAPIN ET AL. unit. Further, th
Page 221 and 222:
298 CHAPIN ET AL. PND 21 and housed
Page 223 and 224:
300 CHAPIN ET AL. Tando et al. (200
Page 225 and 226:
302 CHAPIN ET AL. Purina Certified
Page 227 and 228:
304 CHAPIN ET AL. high-doses of bis
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306 CHAPIN ET AL. born to those dam
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308 CHAPIN ET AL. average weight we
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310 CHAPIN ET AL. study authors con
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312 CHAPIN ET AL. used for extracti
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314 CHAPIN ET AL. jar, and there we
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316 CHAPIN ET AL. of testes and com
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318 CHAPIN ET AL. differentiation o
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320 CHAPIN ET AL. Table 81 Summary
Page 245 and 246:
322 CHAPIN ET AL. Table 82 Continue
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Page 249 and 250:
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328 CHAPIN ET AL. 600 mg/kg bw/day)
Page 253 and 254:
330 CHAPIN ET AL. (Nagao et al., 19
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332 CHAPIN ET AL. antinuclear antib
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334 CHAPIN ET AL. least 6 animals.
Page 259 and 260:
336 CHAPIN ET AL. Utility (Adequacy
Page 261 and 262:
338 CHAPIN ET AL. stomach weight wa
Page 263 and 264:
340 CHAPIN ET AL. Schirling et al.
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342 CHAPIN ET AL. Endpoint Table 88
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344 CHAPIN ET AL. different diets b
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346 CHAPIN ET AL. with 40 mg vitami
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348 CHAPIN ET AL. the bisphenol A v
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350 CHAPIN ET AL. and determining t
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352 CHAPIN ET AL. expression [to B6
Page 277 and 278:
354 CHAPIN ET AL. indicated] at 0 (
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356 CHAPIN ET AL. concentrations us
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358 CHAPIN ET AL. animals were non-
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360 CHAPIN ET AL. following adjustm
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362 CHAPIN ET AL. Table 94 Treatmen
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364 CHAPIN ET AL. Table 97 Effects
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366 CHAPIN ET AL. Table 99 Treatmen
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368 CHAPIN ET AL. Therefore the NTP
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370 CHAPIN ET AL. weeks before mati
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Page 297 and 298:
374 Table 101 Summary of High Utili
Page 299 and 300:
376 Table 102 Summary of Limited Ut
Page 301 and 302:
Page 303 and 304:
380 CHAPIN ET AL. from other suppli
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382 CHAPIN ET AL. U.S. populations.
Page 307 and 308:
384 CHAPIN ET AL. 10. Critical desi
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386 CHAPIN ET AL. Engel SM, Levy B,
Page 311 and 312:
388 CHAPIN ET AL. alpha and beta ex
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390 CHAPIN ET AL. Murray TJ, Maffin
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392 CHAPIN ET AL. Ryan BC, Vandenbe
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394 CHAPIN ET AL. Thomas P, Dong J.
Page 319 and 320:
Page 321:
appendix iii. publiC CommenTs and p
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