Monograph on the Potential Human Reproductive and ... - OEHHA

BISPHENOL A
Table 7
Blood Concentrations of Bisphenol A in Adults
Population (n) Bisphenol A mg/L a,c
Method Reference
Germany
Men (7) o0.5 HPLC-MS/MS Völkel et al. (2005)
Women (12) o0.5 HPLC-MS/MS Völkel et al. (2005)
Pregnant Caucasian women (37; 32–41 4.473.9 GC-MS Schönfelder et al. (2002a)
weeks gestation)
Japan
Men (21; age 22–51) ‘‘almost all’’ o0.2 ng/ml HPLC-ECD Fukata et al. (2006)
Men (9; age 30–50) 0.5970.21 (0.38–1.0) HPLC-MS Sajiki et al.(1999)
Men (11) 1.4970.11 (SEM) ELISA b
Takeuchi and Tsutsumi
(2002)
Women (31; age 22–51) ‘‘almost all’’ o0.2 ng/ml HPLC-ECD Fukata et al. (2006)
Women (12; age 30–50) 0.3370.54 (0–1.6) HPLC-MS Sajiki et al.(1999)
Women (14) 0.6470.10(SEM) ELISA b
Takeuchi and Tsutsumi
Pregnant women (37; late pregnancy) 1.470.9 ELISA
(2002)
b
Ikezuki et al.(2002)
Pregnant women with normal karyotype 2.24 (0.63–14.36) ELISA b
early 2nd trimester (200)
Yamada et al. (2002)
Pregnant women with abnormal 2.97 (B0.0.7–18.5) d
ELISA b
karyotype early 2nd trimester (48)
Yamada et al. (2002)
Pregnant women (9) 0.43 (0.21–0.79) HPLC-Fl Kuroda et al. (2003)
Infertile women (21) 0.46 (0.22–0.87) HPLC-Fl Kuroda et al. (2003)
Women with multiple miscarriages 2.5975.23 ELISA b
Sugiura-Ogasawara et al.
(45; mean age 31.6 years) (2005)
Healthy woman (32; mean age 32 years) 0.7770.38 ELISA b
Sugiura-Ogasawara et al.
(2005)
Women with polycystic ovary syndrome 1.0470.10 (SEM) ELISA b
Takeuchi and Tsutsumi
(16) (2002)
Non-obese women with polycystic 1.0570.10 (SEM) ELISA b
ovarian syndrome (13; average
age 26.5 years)
Takeuchi et al. (2004a)
Obese women with polycystic ovarian 1.1770.16 (SEM) ELISA b
syndrome (6; average age 24.7 years)
Takeuchi et al. (2004a)
Non-obese women (19; average age 27.5 0.7170.09 (SEM) ELISA b
Takeuchi and Tsutsumi
years) (2002)
Obese women (7; average age 28.8 years) 1.0470.09 (SEM) ELISA b
Takeuchi et al. (2004a)
Hyperprolactinemic women (7; average 0.8370.12 (SEM) ELISA b
age 27.7 years)
Takeuchi et al. (2004a)
Amenorrheic women (7; average age 0.8470.10 (SEM) ELISA b
25.1 years)
Takeuchi et al. (2004a)
Women with normal uterine 2.571.5 ELISA b
endometrium (11; mean age 48.9 years
Hiroi et al. (2004)
Women with simple endometrium 2.972.0 ELISA b
hyperplasia (10; mean age 48.4 years)
Hiroi et al. (2004)
Women with complex endometrium 1.470.4 ELISA b
hyperplasia (9; mean age 48.4 years)
Hiroi et al. (2004)
Women with endometrial carcinoma 1.470.5 ELISA b
(7; mean age 63.1 years)
Hiroi et al. (2004)
a
Mean7SD or median (range).
b
As discussed in Section 1.1.5, ELISA may overestimate bisphenol A.
c
It is uncertain whether parent, conjugated, or total bisphenol A was measured.
d
Estimated from a graph.
Schönfelder et al. (2002b) examined bisphenol A
concentrations in maternal and fetal blood and compared
bisphenol A concentrations in blood of male and female
fetuses. In a study conducted at a German medical
center, blood samples were obtained from 37 Caucasian
women between 32 and 41 weeks gestation. At parturition,
blood was collected from the umbilical vein after
expulsion of the placenta. Bisphenol A concentrations in
plasma were measured by GC/MS. Control experiments
were conducted to verify that bisphenol A did not leach
Birth Defects Research (Part B) 83:157–395, 2008
169
from collection, storage, or testing equipment. Bisphenol
A was detected in all samples tested, and concentrations
measured in maternal and fetal blood are summarized in
Table 9. Mean bisphenol A concentrations were higher in
maternal (4.473.9 [SD] mg/L) than fetal blood
(2.972.5 mg/L). Study authors noted that in 14 cases
fetal bisphenol A plasma concentrations exceeded those
detected in maternal plasma. Among those 14 cases, 12
fetuses were male. Analysis by paired t-test revealed
significantly higher mean bisphenol A concentrations in