Monograph on the Potential Human Reproductive and ... - OEHHA
Monograph on the Potential Human Reproductive and ... - OEHHA
Monograph on the Potential Human Reproductive and ... - OEHHA
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prefaCe<br />
The. Nati<strong>on</strong>al. Toxicology. Program. (NTP) 1 .<br />
established.<strong>the</strong>.NTP.Center.for.<strong>the</strong>.Evaluati<strong>on</strong>.<br />
of.Risks.to.<strong>Human</strong>.Reproducti<strong>on</strong>.(CERHR).in.<br />
June. 1998..The. purpose. of. <strong>the</strong>. CERHR. is. to.<br />
provide. timely,. unbiased,. scientifically. sound.<br />
evaluati<strong>on</strong>s.of.<strong>the</strong>.potential.for.adverse.effects.<br />
<strong>on</strong>.reproducti<strong>on</strong>.or.development.resulting.from.<br />
human.exposures.to.substances.in.<strong>the</strong>.envir<strong>on</strong>ment..<br />
The. NTP-CERHR. is. headquartered. at.<br />
<strong>the</strong>.Nati<strong>on</strong>al.Institute.of.Envir<strong>on</strong>mental.Health.<br />
Sciences.(NIEHS).<strong>and</strong>.Dr..Michael.Shelby.is.<br />
<strong>the</strong>.director. 2<br />
CERHR.broadly.solicits.nominati<strong>on</strong>s.of.chemicals.<br />
for. evaluati<strong>on</strong>. from. <strong>the</strong>. public. <strong>and</strong>. private.<br />
sectors.. Chemicals. are. selected. for. evaluati<strong>on</strong>.<br />
based.<strong>on</strong>.several.factors.including.<strong>the</strong>.following:<br />
• potential.for.human.exposure.from.use.<br />
<strong>and</strong>.occurrence.in.<strong>the</strong>.envir<strong>on</strong>ment<br />
• extent.of.public.c<strong>on</strong>cern<br />
• producti<strong>on</strong>.volume<br />
• extent.of.database.<strong>on</strong>.reproductive.<strong>and</strong>.<br />
developmental.toxicity.studies<br />
CERHR.follows.a.formal.process.for.review.<strong>and</strong>.<br />
evaluati<strong>on</strong>.of.nominated.chemicals.that.includes.<br />
multiple. opportunities. for. public. comment..<br />
Briefly,. CERHR. c<strong>on</strong>venes. a. scientific. expert.<br />
panel. that. meets. in. a. public. forum. to. review,.<br />
discuss,.<strong>and</strong>.evaluate.<strong>the</strong>.scientific.literature.<strong>on</strong>.<br />
<strong>the</strong>.selected.chemical..Public.comment.is.invited.<br />
prior.to.<strong>and</strong>.during.<strong>the</strong>.meeting..The.expert.panel.<br />
produces.a.report.<strong>on</strong>.<strong>the</strong>.chemical’s.reproductive.<br />
v<br />
<strong>and</strong>. developmental. toxicities. <strong>and</strong>. provides. its.<br />
opini<strong>on</strong>.of.<strong>the</strong>.degree.to.which.exposure.to.<strong>the</strong>.<br />
chemical. is. hazardous. to. humans.. The. panel.<br />
also. identifies. areas. of. uncertainty. <strong>and</strong>. where.<br />
additi<strong>on</strong>al.data.are.needed..Expert.panel.reports.<br />
are.made.public.<strong>and</strong>.comments.are.solicited.<br />
Next,.CERHR.prepares.<strong>the</strong>.NTP.Brief..The.goal.<br />
of.<strong>the</strong>.NTP.Brief.is.to.provide.<strong>the</strong>.public,.as.well.<br />
as.government.health,.regulatory,.<strong>and</strong>.research.<br />
agencies,.with.<strong>the</strong>.NTP’s.c<strong>on</strong>clusi<strong>on</strong>s.regarding.<br />
<strong>the</strong>. potential. for. <strong>the</strong>. chemical. to. adversely.<br />
affect.human.reproductive.health.or.children’s.<br />
development..CERHR.<strong>the</strong>n.prepares.<strong>the</strong>.NTP-<br />
CERHR.<str<strong>on</strong>g>M<strong>on</strong>ograph</str<strong>on</strong>g>,.which.includes.<strong>the</strong>.NTP.<br />
Brief.<strong>and</strong>.<strong>the</strong>.Expert.Panel.Report..The.NTP-<br />
CERHR.<str<strong>on</strong>g>M<strong>on</strong>ograph</str<strong>on</strong>g>.is.made.publicly.available.<br />
<strong>on</strong>.<strong>the</strong>.CERHR.website.<strong>and</strong>.in.hardcopy.or.CD.<br />
from.CERHR. 12<br />
1 NTP.is.an.interagency.program.headquartered.<br />
in.Research.Triangle.Park,.NC.at.<strong>the</strong>.Nati<strong>on</strong>al.<br />
Institute. of. Envir<strong>on</strong>mental. Health. Sciences,. a.<br />
comp<strong>on</strong>ent.of.<strong>the</strong>.Nati<strong>on</strong>al.Institutes.of.Health.<br />
2<br />
Informati<strong>on</strong>.about.<strong>the</strong>.CERHR.is.available.<strong>on</strong>.<strong>the</strong>.<br />
web.at.http://cerhr.niehs.nih.gov .or.by.c<strong>on</strong>tacting:<br />
Michael.Shelby,.Ph.D.<br />
Director,.CERHR<br />
NIEHS,.P.O..Box.12233,.MD.EC.-.32<br />
Research.Triangle.Park,.NC.27709.<br />
919.-.541.-.3455.[ph<strong>on</strong>e].<br />
919.-.316.-.4511.[fax]<br />
shelby@niehs.nih.gov.[email]
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