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Hiroi H, Tsutsumi O, Momoeda M, Takai Y, Osuga Y, Taketani Y. 1999. Differential interactions of bisphenol A and 17beta-estradiol with estrogen receptor alpha (ERalpha) and ERbeta. Endocr J 46:773–778. Hiroi H, Tsutsumi O, Takeuchi T, Momoeda M, Ikezuki Y, Okamura A, Yokota H, Taketani Y. 2004. Differences in serum bisphenol a concentrations in premenopausal normal women and women with endometrial hyperplasia. Endocr J 51:595–600. Hiroi T, Okada K, Imaoka S, Osada M, Funae Y. 2006. Bisphenol A binds to protein disulfide isomerase and inhibits its enzymatic and hormone-binding activities. Endocrinol 147:2773–2780. Ho SM, Tang WY, Belmonte de Frausto J, Prins G. 2006a. Developmental exposure to estradiol and bisphenol a increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res 66:1–9. Ho SM, Tang WY, Belmonte de Frausto J, Prins GS. 2006b. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res 66(11):5624–5632. Hong EJ, Choi KC, Jeung EB. 2003. Maternal-fetal transfer of endocrine disruptors in the induction of Calbindin-D9k mRNA and protein during pregnancy in rat model. Mol Cell Endocrinol 212:63–72. Hong EJ, Choi KC, Jeung EB. 2005. Maternal exposure to bisphenol a during late pregnancy resulted in an increase of Calbindin-D9k mRNA and protein in maternal and postnatal rat uteri. J Reprod Dev 51:499–508. Hong EJ, Choi KC, Jung YW, Leung PC, Jeung EB. 2004. Transfer of maternally injected endocrine disruptors through breast milk during lactation induces neonatal Calbindin-D9k in the rat model. Reprod Toxicol 18:661–668. Honkanen JO, Holopainen IJ, Kukkonen JV. 2004. Bisphenol A induces yolk-sac oedema and other adverse effects in landlocked salmon (Salmo salar m. sebago) yolk-sac fry. Chemosphere 55:187–196. Honma S, Suzuki A, Buchanan DL, Katsu Y, Watanabe H, Iguchi T. 2002. Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction. Reprod Toxicol 16:117–122. Howdeshell KL, Hotchkiss AK, Thayer KA, Vandenbergh JG, vom Saal FS. 1999. Exposure to bisphenol A advances puberty. Nature 401:763–764. Howdeshell KL, vom Saal FS. 2000. Developmental exposure to bisphenol A: interaction with endogenous estradiol during pregnancy in mice. Am Zool 40:429–437. Howe SR, Borodinsky L. 1998. Potential exposure to bisphenol A from food-contact use of polycarbonate resins. Food Addit Contam 15:370–375. Howe SR, Borodinsky L, Lyon RS. 1998. Potential exposure to bisphenol A from food-contact use of epoxy coated cans. J Coatings Technol 70:69–74. HSDB. 2003. Bisphenol A. Available at http://toxnet.nlm.nih.gov/cgibin/sis/htmlgen?HSDB. Hu JY, Aizawa T, Ookubo S. 2002. Products of aqueous chlorination of bisphenol A and their estrogenic activity. Environ Sci Technol 36:1980–1987. Huff J. 2001. Carcinogenicity of bisphenol-A in Fischer rats and B6C3F1 mice. Odontology 89:12–20. Hughes PJ, McLellan H, Lowes DA, Khan SZ, Bilmen JG, Tovey SC, Godfrey RE, Mitchell RH, Kirk CJ, Michelangeli F. 2000. Estrogenic alkylphenols induce cell death by inhibiting testis endoplasmic reticulum Ca21 pumps. Biochem Biophys Res Commun 277:568– 574. Hunt PA, Koehler KE, Susiarjo M, Hodges CA, Ilagan A, Voigt RC, Thomas S, Thomas BF, Hassold TJ. 2003. Bisphenol a exposure causes meiotic aneuploidy in the female mouse. Curr Biol 13:546–553. Ichihara T, Yoshino H, Imai N, Tsutsumi T, Kawabe M, Tamano S, Inaguma S, Suzuki S, Shirai T. 2003. Lack of carcinogenic risk in the prostate with transplacental and lactational exposure to bisphenol A in rats. J Toxicol Sci 28:165–171. Iida H, Maehara K, Doiguchi M, Mori T, Yamada F. 2003. Bisphenol Ainduced apoptosis of cultured rat Sertoli cells. Reprod Toxicol 17:457–464. Iida H, Mori T, Kaneko T, Urasoko A, Yamada F, Shibata Y. 2002. Disturbed spermatogenesis in mice prenatally exposed to an endocrine disruptor, bisphenol A. Mammal Study 22:73–82. Ikezuki Y, Tsutsumi O, Takai Y, Kamei Y, Taketani Y. 2002. Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure. Hum Reprod 17:2839–2841. Imanishi S, Manabe N, Nishizawa H, Morita M, Sugimoto M, Iwahori M, Miyamoto H. 2003. Effects of oral exposure of bisphenol A on mRNA expression of nuclear receptors in murine placentae assessed by DNA microarray. J Reprod Dev 49:329–336. Imaoka S, Mori T, Kinoshita T. 2007. Bisphenol A causes malformation of the head region in embryos of Xenopus laevis and decreases the expression of the ESR-1 gene mediated by Notch signaling. Biol Pharm Bull 30:371–374. Birth Defects Research (Part B) 83:157–395, 2008 BISPHENOL A 387 Inoue H, Tsuruta A, Kudo S, Ishii T, Fukushima Y, Iwano H, Yokota H, Kato S. 2004. Bisphenol a glucuronidation and excretion in liver of pregnant and nonpregnant female rats. Drug Metab Dispos 33:55–59. Inoue H, Yuki G, Yokota H, Kato S. 2003a. Bisphenol A glucuronidation and absorption in rat intestine. Drug Metab Dispos 31:140–144. Inoue K, Kato K, Yoshimura Y, Makino T, Nakazawa H. 2000. Determination of bisphenol A in human serum by high-performance liquid chromatography with multi-electrode electrochemical detection. J Chromatogr B Biomed Sci Appl 749:17–23. Inoue K, Murayama S, Takeba K, Yoshimura Y, Nakazawa H. 2003b. Contamination of xenoestrogens bisphenol A and F in honey: safety assessment and analytical method of these compounds in honey. J Food Compost Anal 16:497–506. Inoue K, Wada M, Higuchi T, Oshio S, Umeda T, Yoshimura Y, Nakazawa H. 2002. Application of liquid chromatography-mass spectrometry to the quantification of bisphenol A in human semen. J Chromatogr B Analyt Technol Biomed Life Sci 773:97–102. Ishido M, Masuo Y, Kunimoto M, Oka S, Morita M. 2004. Bisphenol A causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity. J Neurosci Res 76:423–433. Ishido M, Morita M, Oka S, Masuo Y. 2005. Alteration of gene expression of G protein-coupled receptors in endocrine disruptors-caused hyperactive rats. Regul Pept 126:145–153. Iso T, Watanabe T, Iwamoto T, Shimamoto A, Furuichi Y. 2006. DNA damage caused by bisphenol A and estradiol through estrogenic activity. Biol Pharm Bull 29:206–210. Iwamuro S, Sakakibara M, Terao M, Ozawa A, Kurobe C, Shigeura T, Kato M, Kikuyama S. 2003. Teratogenic and anti-metamorphic effects of bisphenol A on embryonic and larval Xenopus laevis. Gen Comp Endocrinol 133:189–198. Iwasaki T, Totsukawa K. 2003. Change in Sexual maturation and estrogen receptor expression in mouse fetuses exposed to bisphenol A. Environ Sci 10:239–246. Jaeg JP, Perdu E, Dolo L, Debrauwer L, Cravedi JP, Zalko D. 2004. Characterization of new bisphenol a metabolites produced by CD1 mice liver microsomes and S9 fractions. J Agric Food Chem 52: 4935–4942. Jobling S, Casey D, Rogers-Gray T, Oehlmann J, Schulte-Oehlmann U, Pawlowski S, Baunbeck T, Turner AP, Tyler CR. 2004. Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent. Aquat Toxicol 66:207–222. Joskow R, Barr DB, Barr JR, Calafat AM, Needham LL, Rubin C. 2006. Exposure to bisphenol A from bis-glycidyl dimethacrylate-based dental sealants. J Am Dent Assoc 137:353–362. Kabuto H, Amakawa M, Shishibori T. 2004. Exposure to bisphenol A during embryonic/fetal life and infancy increases oxidative injury and causes underdevelopment of the brain and testis in mice. Life Sci 74:2931–2940. Kabuto H, Hasuike S, Minagawa N, Shishibori T. 2003. Effects of bisphenol A on the metabolisms of active oxygen species in mouse tissues. Environ Res 93:31–35. Kang IJ, Yokota H, Oshima Y, Tsuruda Y, Oe T, Imada N, Tadokoro H, Honjo T. 2002. Effects of bisphenol A on the reproduction of Japanese medaka (Oryzias latipes). Environ Toxicol Chem 21:2394–2400. Kang JH, Katayama Y, Kondo F. 2006. Biodegradation or metabolism of bisphenol A: From microorganisms to mammals. Toxicology 217: 81–90. Kang JH, Kito K, Kondo F. 2003. Factors influencing the migration of bisphenol A from cans. J Food Prot 66:1444–1447. Kanno J, Onyon L, Peddada S, Ashby J, Jacob E, Owens W. 2003a. The OECD program to validate the rat uterotrophic bioassay. Phase 2: coded single-dose studies. Environ Health Perspect 111:1550–1558. Kanno J, Onyon L, Peddada S, Ashby J, Jacob E, Owens W. 2003b. The OECD program to validate the rat uterotrophic bioassay. Phase 2: dose–response studies. Environ Health Perspect 111:1530–1549. Kato H, Furuhashi T, Tanaka M, Katsu Y, Watanabe H, Ohta Y, Iguchi T. 2006. Effects of bisphenol A given neonatally on reproductive functions of male rats. Reprod Toxicol 22:20–19. Kato H, Ota T, Furuhashi T, Ohta Y, Iguchi T. 2003. Changes in reproductive organs of female rats treated with bisphenol A during the neonatal period. Reprod Toxicol 17:283–288. Kawagoshi Y, Fujita Y, Kishi I, Fukunaga I. 2003. Estrogenic chemicals and estrogenic activity in leachate from municipal waste landfill determined by yeast two-hybrid assay. J Environ Monit 5:269–274. Kawaguchi M, Inoue K, Yoshimura M, Ito R, Sakui N, Okanouchi N, Nakazawa H. 2004. Determination of bisphenol A in river water and body fluid samples by stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 805:41–48. Kawai K, Murakami S, Senba E, Yamanaka T, Fujiwara Y, Arimura C, Nozaki T, Takii M, Kubo C. 2007. Changes in estrogen receptors
388 CHAPIN ET AL. alpha and beta expression in the brain of mice exposed prenatally to bisphenol A. Regul Toxicol Pharmacol 47:166–170. Kawai K, Nozaki T, Nishikata H, Aou S, Takii M, Kubo C. 2003. Aggressive behavior and serum testosterone concentration during the maturation process of male mice: the effects of fetal exposure to bisphenol A. Environ Health Perspect 111:175–178. Kawamura Y, Sano H, Yamada T. 1999. Migration of bisphenol A from can coatings to drinks. Shokuhin Eiseigaku Zasshi 40:158–165. Khurana S, Ranmal S, Ben-Jonathan N. 2000. Exposure of newborn male and female rats to environmental estrogens: delayed and sustained hyperprolactinemia and alterations in estrogen receptor expression. Endocrinology 141:4512–4517. Kim HS, Han SY, Kim TS, Kwack SJ, Lee RD, Kim IY, Seok JH, Lee BM, Yoo SD, Park KL. 2002a. No androgenic/anti-androgenic effects of bisphenol-A in Hershberger assay using immature castrated rats. Toxicol Lett 135:111–123. Kim HS, Han SY, Yoo SD, Lee BM, Park KL. 2001a. Potential estrogenic effects of bisphenol-A estimated by in vitro and in vivo combination assays. J Toxicol Sci 26:111–118. Kim HS, Kang TS, Kang IH, Kim TS, Moon HJ, Kim IY, Ki H, Park KL, Lee BM, Yoo SD, Han SY. 2005. Validation study of OECD rodent uterotrophic assay for the assessment of estrogenic activity in Sprague-Dawley immature female rats. J Toxicol Environ Health A 68:2249–2262. Kim JC, Shin HC, Cha SW, Koh WS, Chung MK, Han SS. 2001b. Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancy. Life Sci 69:2611–2625. Kim KB, Soo KW, Kim YJ, Park M, Park CW, Kim PY, Kim JI, Lee SH. 2003a. Estrogenic effects of phenolic compounds on glucose-6phosphate dehydrogenase in MCF-7 cells and uterine glutathione peroxidase in rats. Chemosphere 50:1167–1173. Kim MJ, Choi BS, Park JD, Hong YP. 2002b. Male reproductive toxicity of subchronic bisphenol A exposure in F344 rats. Chung Ang Ui Dai Chi 24:111–120. Kim P LN, Hwang S. 2003. The bisphenol A: a modulator of pregnancy in rats. Kor J Env Hlth Soc 29:27–34. Kim YH, Kim CS, Park S, Han SY, Pyo MY, Yang M. 2003b. Gender differences in the levels of bisphenol A metabolites in urine. Biochem Biophys Res Commun 312:441–448. Kinnberg K, Toft G. 2003. Effects of estrogenic and antiandrogenic compounds on the testis structure of the adult guppy (Poecilia reticulata). Ecotoxicol Environ Saf 54:16–24. Kishida M, McLellan M, Miranda JA, Callard GV. 2001. Estrogen and xenoestrogens upregulate the brain aromatase isoform (P450aromB) and perturb markers of early development in zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol 129:261–268. Kitamura S, Suzuki T, Sanoh S, Kohta R, Jinno N, Sugihara K, Yoshihara S, Fujimoto N, Watanabe H, Ohta S. 2005. Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds. Toxicol Sci 84:249–259. Kloas W, Lutz I, Einspanier R. 1999. Amphibians as a model to study endocrine disruptors: II. Estrogenic activity of environmental chemicals in vitro and in vivo. Sci Total Environ 225:59–68. Klotz DM, Hewitt SC, Korach KS, Diaugustine RP. 2000. Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: requirement of estrogen receptor-alpha. Endocrinology 141:3430–3439. Kobayashi K, Miyagawa M, Wang RS, Sekiguchi S, Suda M, Honma T. 2002. Effects of in utero and lactational exposure to bisphenol A on somatic growth and anogenital distance in F1 rat offspring. Ind Health 40:375–381. Kobayashi K, Miyagawa M, Wang RS, Suda M, Sekiguchi S, Honma T. 2005. Effects of in utero and lactational exposure to bisphenol A on thyroid status in F1 rat offspring. Ind Health 43:685–690. Koda T, Umezu T, Kamata R, Morohoshi K, Ohta T, Morita M. 2005. Uterotrophic effects of benzophenone derivatives and a p-hydroxybenzoate used in ultraviolet screens. Environ Res 98:40–45. Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT. 2002. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999–2000: a national survey. Environ Sci Technol 36:1202–1211. Körner W, Bolz U, Sussmuth W, Hiller G, Schuller W, Hanf V, Hagenmaier H. 2000. Input/output balance of estrogenic active compounds in a major municipal sewage plant in Germany. Chemosphere 40:1131–1142. Krishnan AV, Stathis P, Permuth SF, Tokes L, Feldman D. 1993. Bisphenol A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 132:2279–2286. Kubo K, Arai O, Ogata R, Omura M, Hori T, Aou S. 2001. Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the rat. Neurosci Lett 304:73–76. Kubo K, Arai O, Omura M, Watanabe R, Ogata R, Aou S. 2003. Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats. Neurosci Res 45:345–356. Kuch HM, Ballschmiter K. 2001. Determination of endocrine-disrupting phenolic compounds and estrogens in surface and drinking water by HRGC-(NCI)-MS in the picogram per liter range. Environ Sci Technol 35:3201–3206. Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson JA. 1997. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138:863–870. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JA. 1998. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139:4252–4263. Kuo H-W, Ding W-H. 2004. Trace deternination of bisphenol A and phytoestrogens in infant formula powders by gas chromatographymass spectometry. J Chromatogr A 1027:67–74. Kurebayashi H, Betsui H, Ohno Y. 2003. Disposition of a low dose of 14Cbisphenol A in male rats and its main biliary excretion as BPA glucuronide. Toxicol Sci 73:17–25. Kurebayashi H, Harada R, Stewart RK, Numata H, Ohno Y. 2002. Disposition of a low dose of bisphenol a in male and female cynomolgus monkeys. Toxicol Sci 68:32–42. Kurebayashi H, Nagatsuka S, Nemoto H, Noguchi H, Ohno Y. 2005. Disposition of low doses of 14C-bisphenol A in male, female, pregnant, fetal, and neonatal rats. Arch Toxicol 79:243–252. Kuroda N, Kinoshita Y, Sun Y, Wada M, Kishikawa N, Nakashima K, Makino T, Nakazawa H. 2003. Measurement of bisphenol A levels in human blood serum and ascitic fluid by HPLC using a fluorescent labeling reagent. J Pharm Biomed Anal 30:1743–1749. Kurosawa T, Hiroi H, Tsutsumi O, Ishikawa T, Osuga Y, Fujiwara T, Inoue S, Muramatsu M, Momoeda M, Taketani Y. 2002. The activity of bisphenol A depends on both the estrogen receptor subtype and the cell type. Endocr J 49:465–471. Kuruto-Niwa R, Tateoka Y, Usuki Y, Nozawa R. 2007. Measurement of bisphenol A concentrations in human colostrum. Chemosphere 66:1160–1164. Kwak HI, Bae MO, Lee MH, Lee YS, Lee BJ, Kang KS, Chae CH, Sung HJ, Shin JS, Kim JH, Mar WC, Sheen YY, Cho MH. 2001. Effects of nonylphenol, bisphenol A, and their mixture on the viviparous swordtail fish (Xiphophorus helleri). Environ Toxicol Chem 20: 787–795. Kwon S, Stedman D, Elswick B, Cattley RC, Welsch F. 1999. Estrous cyclicity and ovarian morphology of rats exposed to bisphenol A or diethystilbestrol during prenatal and postnatal development. Biol Reprod 60(Suppl):199. Kwon S, Stedman DB, Elswick BA, Cattley RC, Welsch F. 2000. Pubertal development and reproductive functions of Crl:CD BR Sprague- Dawley rats exposed to bisphenol A during prenatal and postnatal development. Toxicol Sci 55:399–406. Lahnsteiner F, Berger B, Kletzl M, Weismann T. 2005. Effect of bisphenol A on maturation and quality of semen and eggs in the brown trout, Salmo trutta f.fario. Aquat Toxicol 75:213–224. Laviola G, Gioiosa L, Adriani W, Palanza P. 2005. D-amphetamine-related reinforcing effects are reduced in mice exposed prenatally to estrogenic endocrine disruptors. Brain Res Bull 65:235–240. Laws SC, Carey SA, Ferrell JM, Bodman GJ, Cooper RL. 2000. Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Toxicol Sci 54:154–167. Lee HJ, Chattopadhyay S, Gong EY, Ahn RS, Lee K. 2003a. Antiandrogenic effects of bisphenol A and nonylphenol on the function of androgen receptor. Toxicol Sci 75:40–46. Lee WK, Lee KW, Kwak EJ, Yang SW, Yang KS, Park JC, Joo HS, Lee WJ, Lee WB. 2003b. Effects of environmental endocrine disruptors on the sex differentiation in Korean rockfish, Sebastes schlegeli. Water Sci Technol 47:65–70. Leffers H, Naesby M, Vendelbo B, Skakkebaek NE, Jorgensen M. 2001. Oestrogenic potencies of Zeranol, oestradiol, diethylstilboestrol, Bisphenol-A and genistein: implications for exposure assessment of potential endocrine disrupters. Hum Reprod 16:1037–1045. Lemmen JG, Arends RJ, van der Saag PT, van der Burg B. 2004. In vivo imaging of activated estrogen receptors in utero by estrogens and bisphenol A. Environ Health Perspect 112:1544–1549. Letcher RJ, Sanderson JT, Bokkers A, Giesy JP, van den Berg M. 2005. Effects of bisphenol A-related diphenylalkanes on vitellogenin production in male carp (Cyprinus carpio) hepatocytes and aromatase (CYP19) activity in human H295R adrenocortical carcinoma cells. Toxicol Appl Pharmacol 209:95–104. Levy G, Lutz I, Kruger A, Kloas W. 2004. Bisphenol A induces feminization in Xenopus laevis tadpoles. Environ Res 94:102–111. Lewis JB, Rueggeberg FA, Lapp CA, Ergle JW, Schuster GS. 1999. Identification and characterization of estrogen-like components in Birth Defects Research (Part B) 83:157–395, 2008
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solid.phase.extraction-high.perform
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appendix i. nTp-Cerhr bisphenol a e
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158 CHAPIN ET AL. the CERHR Core Co
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160 CHAPIN ET AL. referred to as 4,
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162 CHAPIN ET AL. concentrations in
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164 CHAPIN ET AL. Food (no. sampled
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166 CHAPIN ET AL. Table 6 Continued
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168 CHAPIN ET AL. comparison of the
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170 CHAPIN ET AL. Table 8 Urinary C
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172 CHAPIN ET AL. the blood of male
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174 CHAPIN ET AL. Table 11 Bispheno
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176 CHAPIN ET AL. Table 13 Summarie
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178 CHAPIN ET AL. Table 15 Estimate
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180 CHAPIN ET AL. Table 17 Maximum
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182 CHAPIN ET AL. 2.0 GENERAL TOXIC
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184 CHAPIN ET AL. fetuses (3.572.7
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186 CHAPIN ET AL. Secondary sources
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188 CHAPIN ET AL. Table 25 Maternal
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190 CHAPIN ET AL. Table 27 Bispheno
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192 CHAPIN ET AL. Table 31 Qualitat
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194 CHAPIN ET AL. Table 33 Toxicoki
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198 CHAPIN ET AL. appeared to occur
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200 CHAPIN ET AL. Table 43 Biliary
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202 CHAPIN ET AL. suggesting that 4
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204 CHAPIN ET AL. low following ora
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206 CHAPIN ET AL. scaling and speci
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208 CHAPIN ET AL. 60-100% in each d
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210 CHAPIN ET AL. related. No histo
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212 CHAPIN ET AL. Table 52 Continue
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214 CHAPIN ET AL. Model and exposur
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216 CHAPIN ET AL. Model and exposur
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218 Model and exposure Husbandry a
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220 CHAPIN ET AL. Table 54 Differen
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222 CHAPIN ET AL. Table 56 Anti-And
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224 Table 57 In Vitro Genetic Toxic
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226 CHAPIN ET AL. Table 58 In Vivo
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228 CHAPIN ET AL. Table 59 Developm
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232 CHAPIN ET AL. Table 64 Tissue R
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236 CHAPIN ET AL. treatment conditi
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238 CHAPIN ET AL. clinical signs, b
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240 CHAPIN ET AL. Table 71 Benchmar
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242 CHAPIN ET AL. group, 5 from 1 l
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244 CHAPIN ET AL. least significant
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246 CHAPIN ET AL. group was a reduc
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248 CHAPIN ET AL. 100-151 g for fem
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250 CHAPIN ET AL. 3.2.3.2 Developme
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252 CHAPIN ET AL. weights, bispheno
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254 CHAPIN ET AL. 120 mg/kg bw/day
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256 CHAPIN ET AL. comparisons condu
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258 CHAPIN ET AL. the findings of t
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260 CHAPIN ET AL. analyzed.] Anogen
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262 CHAPIN ET AL. purposeful confou
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264 CHAPIN ET AL. increased lordosi
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266 CHAPIN ET AL. that there was a
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268 CHAPIN ET AL. duration of adver
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270 CHAPIN ET AL. doses of potent e
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272 CHAPIN ET AL. Table 74 Effects
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274 CHAPIN ET AL. reproductive orga
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276 CHAPIN ET AL. tyrosine-hydroxly
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278 CHAPIN ET AL. include small sam
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280 CHAPIN ET AL. males/group. [It
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282 CHAPIN ET AL. termination, whic
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284 CHAPIN ET AL. provided a reliab
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286 CHAPIN ET AL. grooming, and out
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288 CHAPIN ET AL. method of oral do
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290 CHAPIN ET AL. reared by their d
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292 CHAPIN ET AL. has been informed
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294 CHAPIN ET AL. buffered paraform
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296 CHAPIN ET AL. unit. Further, th
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298 CHAPIN ET AL. PND 21 and housed
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300 CHAPIN ET AL. Tando et al. (200
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302 CHAPIN ET AL. Purina Certified
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304 CHAPIN ET AL. high-doses of bis
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306 CHAPIN ET AL. born to those dam
Page 231 and 232:
308 CHAPIN ET AL. average weight we
Page 233 and 234:
310 CHAPIN ET AL. study authors con
Page 235 and 236:
312 CHAPIN ET AL. used for extracti
Page 237 and 238:
314 CHAPIN ET AL. jar, and there we
Page 239 and 240:
316 CHAPIN ET AL. of testes and com
Page 241 and 242:
318 CHAPIN ET AL. differentiation o
Page 243 and 244:
320 CHAPIN ET AL. Table 81 Summary
Page 245 and 246:
322 CHAPIN ET AL. Table 82 Continue
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
328 CHAPIN ET AL. 600 mg/kg bw/day)
Page 253 and 254:
330 CHAPIN ET AL. (Nagao et al., 19
Page 255 and 256:
332 CHAPIN ET AL. antinuclear antib
Page 257 and 258:
334 CHAPIN ET AL. least 6 animals.
Page 259 and 260: 336 CHAPIN ET AL. Utility (Adequacy
Page 261 and 262: 338 CHAPIN ET AL. stomach weight wa
Page 263 and 264: 340 CHAPIN ET AL. Schirling et al.
Page 265 and 266: 342 CHAPIN ET AL. Endpoint Table 88
Page 267 and 268: 344 CHAPIN ET AL. different diets b
Page 269 and 270: 346 CHAPIN ET AL. with 40 mg vitami
Page 271 and 272: 348 CHAPIN ET AL. the bisphenol A v
Page 273 and 274: 350 CHAPIN ET AL. and determining t
Page 275 and 276: 352 CHAPIN ET AL. expression [to B6
Page 277 and 278: 354 CHAPIN ET AL. indicated] at 0 (
Page 279 and 280: 356 CHAPIN ET AL. concentrations us
Page 281 and 282: 358 CHAPIN ET AL. animals were non-
Page 283 and 284: 360 CHAPIN ET AL. following adjustm
Page 285 and 286: 362 CHAPIN ET AL. Table 94 Treatmen
Page 287 and 288: 364 CHAPIN ET AL. Table 97 Effects
Page 289 and 290: 366 CHAPIN ET AL. Table 99 Treatmen
Page 291 and 292: 368 CHAPIN ET AL. Therefore the NTP
Page 293 and 294: 370 CHAPIN ET AL. weeks before mati
Page 295 and 296: 372 CHAPIN ET AL. Table 100 Summary
Page 297 and 298: 374 Table 101 Summary of High Utili
Page 299 and 300: 376 Table 102 Summary of Limited Ut
Page 301 and 302: 378 CHAPIN ET AL. Table 103 Summary
Page 303 and 304: 380 CHAPIN ET AL. from other suppli
Page 305 and 306: 382 CHAPIN ET AL. U.S. populations.
Page 307 and 308: 384 CHAPIN ET AL. 10. Critical desi
Page 309: 386 CHAPIN ET AL. Engel SM, Levy B,
Page 313 and 314: 390 CHAPIN ET AL. Murray TJ, Maffin
Page 315 and 316: 392 CHAPIN ET AL. Ryan BC, Vandenbe
Page 317 and 318: 394 CHAPIN ET AL. Thomas P, Dong J.
Page 319 and 320: [This page inTenTionally lefT blank
Page 321: appendix iii. publiC CommenTs and p
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