Monograph on the Potential Human Reproductive and ... - OEHHA
Monograph on the Potential Human Reproductive and ... - OEHHA
Monograph on the Potential Human Reproductive and ... - OEHHA
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216 CHAPIN ET AL.<br />
Model <strong>and</strong> exposure Husb<strong>and</strong>ry a<br />
Immature <strong>and</strong> adult<br />
ovariectomized Wistar,<br />
gavage x 4 days<br />
Immature Sprague–<br />
Dawley, s.c. x 3 days<br />
Immature Sprague–<br />
Dawley, s.c. x 3 days<br />
Immature Alpk:ApfSD,<br />
gavage x 3 days<br />
Immature AP, s.c. x 3<br />
days<br />
Adult ovariectomized<br />
Sprague–Dawley,<br />
diet x 3 m<strong>on</strong>ths<br />
Immature Sprague–<br />
Dawley, s.c. x 3 days<br />
Adult ovariectomized<br />
Crj:CD (SD), s.c. x 3<br />
days<br />
Adult Holzman,<br />
progester<strong>on</strong>e-treated to<br />
delay implantati<strong>on</strong>,<br />
given test agent s.c. <strong>on</strong><br />
GD 7<br />
Rat vagina<br />
Adult ovariectomized<br />
F344, i.p. x 1<br />
Adult ovariectomized<br />
L<strong>on</strong>g Evans, bisphenol<br />
A by gavage x 11 days;<br />
17b-estradiol by s.c.<br />
L<strong>on</strong>g–Evans treated<br />
PND 21–35 by gavage<br />
Adult ovariectomized<br />
F344 <strong>and</strong> Sprague–<br />
Dawley, i.p. x 1<br />
AO4C diet, wire<br />
cage<br />
Soy-free feed,<br />
polycarb<strong>on</strong>ate<br />
cage<br />
Shinch<strong>on</strong> diet<br />
RM1 diet,<br />
polycarb<strong>on</strong>ate<br />
cage<br />
RM1 diet,<br />
polypropylene<br />
cages,<br />
sawdust <strong>and</strong><br />
shredded<br />
paper bedding<br />
Phytoestrogenfree<br />
diet<br />
PMI Certified<br />
Rodent Diet<br />
Estrogen-free<br />
NIH-07PLD<br />
diet,<br />
aluminum<br />
cage, paper<br />
bedding<br />
Unspecified<br />
Purina rodent<br />
chow, plastic<br />
cage, pine<br />
shavings<br />
Not indicated<br />
Purina 5001 diet<br />
Purina 5001 diet<br />
Not indicated<br />
Table 53<br />
C<strong>on</strong>tinued<br />
Endpoint Molar potency/comparator b<br />
Uterine wet <strong>and</strong> dry<br />
weight<br />
Calbindin D9k protein<br />
Uterine wet weight<br />
Uterine wet weight<br />
relative to bw<br />
Glutathi<strong>on</strong>e peroxidase<br />
activity<br />
Blotted uterine weight<br />
Expressi<strong>on</strong> of:<br />
Progester<strong>on</strong>e receptor A<br />
Progester<strong>on</strong>e receptor B<br />
Complement C3<br />
Lipocalcin<br />
Uterine wet weight<br />
Uterine dry weight<br />
Uterine weight,<br />
endometrial thickness,<br />
ERa, ERb expressi<strong>on</strong><br />
Complement C3<br />
expressi<strong>on</strong><br />
Uterine wet weight<br />
Uterine dry weight<br />
Uterine wet weight,<br />
relative to bw<br />
Blotted uterine weight,<br />
relative to bw<br />
Implantati<strong>on</strong><br />
BrdU labeling<br />
cfos expressi<strong>on</strong><br />
Vaginal cytology<br />
Vaginal opening<br />
BrdU labeling<br />
No effect in ei<strong>the</strong>r model of bisphenol<br />
Aat r200 mg/kg bw/day/17bestradiol<br />
positive at 0.025–<br />
0.035 mg/kg bw/day<br />
[5.1 x 10 -5 ]/17b-estradiol<br />
[1.5 x 10 -6 ]/17b-estradiol<br />
[1.3 x 10 -6 ]/17b-estradiol<br />
[4.2 x 10 -3 ]/17b-estradiol<br />
[2.5 x 10 -4 ]/17b-estradiol<br />
[3.8 x 10 -4 ]/17b-estradiol<br />
[4.2 x 10 -4 ]/17b-estradiol<br />
[1.8 x 10 -4 ]/17b-estradiol<br />
[2.3 x 10 -4 ]/17b-estradiol<br />
[1.0 x 10 -6 ]/ethinyl estradiol<br />
[1.2 x 10 -6 ]/ethinyl estradiol<br />
No bisphenol A effect at 0.37 mg/kg<br />
bw/day; estradiol benzoate positive<br />
c<strong>on</strong>trol<br />
Bisphenol A <strong>and</strong> estradiol benzoate<br />
produced opposite effects<br />
[4.5 x 10 -7 ]/ethinyl estradiol<br />
[4.9 x 10 -7 ]/ethinyl estradiol<br />
[2.1 x 10 -5 ]/17b-estradiol<br />
[1.7 x 10 -6 ]/17b-estradiol<br />
[4–34 x 10 -6 ]/estr<strong>on</strong>e<br />
Increased at bisphenol A dose of 37.5<br />
but not 18.5 mg/kg bw/no<br />
comparator<br />
[1.3 x 10 -4 ]/17b-estradiol<br />
No effect at bisphenol A dose of<br />
100 mg/kg bw/day; 17b-estradiol<br />
0.005 mg/kg bw/day resulted in<br />
persistent estrus<br />
No effect at bisphenol A dose<br />
r400 mg/kg bw/day; ethinyl<br />
estradiol was active at 0.01 mg/kg<br />
bw/day<br />
F344: [4.5 x 10 -6 ]/17b-estradiol<br />
Sprague–Dawley: [1.4 x 10 -6 ]/17bestradiol<br />
Reference<br />
Stroheker et al.<br />
(2003)<br />
An et al. (2003)<br />
Kim et al.<br />
(2003a)<br />
Ashby <strong>and</strong><br />
Odum (2004)<br />
Tinwell <strong>and</strong><br />
Ashby (2004)<br />
Seidlová-Wuttke<br />
et al. (2004)<br />
Kim et al. (2005)<br />
Koda et al. (2005)<br />
Cummings <strong>and</strong><br />
Laws (2000)<br />
Steinmetz et al.<br />
(1998)<br />
Laws et al. (2000)<br />
Laws et al. (2000)<br />
L<strong>on</strong>g et al. (2000)<br />
Birth Defects Research (Part B) 83:157–395, 2008