Monograph on the Potential Human Reproductive and ... - OEHHA

Country Study population
BISPHENOL A 171
Table 8
Continued
Urinary bisphenol A or metabolite concentrations as median
(range) or mean7SEM, mg/L a [detectable fraction, % 4LOD]
LOD
(mg/L) Free Total Glucuronide Sulfate Reference
China 10 healthy man 2.8 o2.7 –3950 Mao et al. (2004)
volunteers; 122071380 d [60%]
21–29 years of age
China 10 healthy woman 2.8 30–3740 Mao et al. (2004)
volunteers; 129071220 d [100%]
21–29 years of age
a
With the exception of the study by Fujimaki et al. (2004), which used the potentially unreliable ELISA, the studies used analytical
techniques based on HPLC, GC/MS, and LC/MS.
b
Limit of detection (LOD) for bisphenol A following digestion of conjugate was 0.3 mg/L.
c
Samples were only digested with b-glucuronidase and do not account for bisphenol A conjugated to sulfate.
d
Variance not indicated.
e
Minimum detection limit based upon free bisphenol A.
Study description (analytical
method)
Table 9
Concentrations of Bisphenol A in Maternal and Fetal Samples
Bisphenol A concentrations, mg/L median (range) or mean7SD
Serum or plasma
Maternal Fetal Amniotic fluid
Reference
21 samples collected in women
0.5 (Non-detectable Engel et al. (2006)
in the U.S. before 20 weeks o0.5–1.96) 10% of
gestation (LC with
electrochemical detection)
samples detectable
37 German women, 32–41 weeks 3.1 (0.3–18.9) 4.473.9 2.3 (0.2–9.2) 2.972.5 Schönfelder et al.
gestation (GC/MS) (2002b)
37 Japanese women in early
pregnancy (ELISA)
1.571.2 Ikezuki et al. (2002)
a
37 Japanese women in late
pregnancy (ELISA)
1.470.9 Ikezuki et al. (2002)
a
32 Japanese infants at delivery
(ELISA)
2.271.8 Ikezuki et al. (2002)
a
32 Japanese amniocentesis
samples at 15–18 weeks
gestation (ELISA)
8.378.9 Ikezuki et al. (2002)
a
38 samples obtained at full-term
cesarean section (ELISA)
1.171.0 Ikezuki et al. (2002)
a
200 Japanese women carrying
fetuses with normal karyotype
at 16 weeks mean gestation
(ELISA)
2.24 (0.63–14.36) 0.26 (0–5.62) Yamada et al. (2002)
48 Japanese women carrying 2.97 [B0.7–18.5] b
0 [B0–7.5] b
fetuses with abnormal
karyotypes at a 16 weeks
mean gestation (ELISA)
Yamada et al. (2002)
9 sets of maternal and umbilical 0.43 (0.21–0.79) 0.64 (0.45–0.76) Kuroda et al. (2003)
cord blood samples obtained
at birth in Japanese patients
(HPLC)
0.4670.2 0.6270.13
180 Malaysian newborns (GC/ Non-detectable Tan and Mohd (2003)
MS) (o0.05) to 4.05 88%
of samples
detectable
a
As discussed in Section 1.1.5, ELISA may overestimate bisphenol A. Some samples were verified by HPLC.
b
Estimated from a graph.
Birth Defects Research (Part B) 83:157–395, 2008