Monograph on the Potential Human Reproductive and ... - OEHHA

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nTp brief activities.of.androgen.receptor-mediated. reporter.gene..44:1916.–.1921. 78.. Kitamura.S,.Suzuki.T,.Sanoh.S,.Kohta.R,. Jinno.N,.Sugihara.K,.Yoshihara.S,.Fujimoto.N,.Watanabe.H,.Ohta.S.(2005).ToxicolSci..Comparative.study.of.the.endocrinedisrupting.activity.of.bisphenol.A.and.19. related.compounds..84:249.–.259. 79.. Paris.F,.Balaguer.P,.Terouanne.B,.Servant. N,. Lacoste. C,. Cravedi. JP,. Nicolas. JC,. Sultan. C. (2002). Mol Cell Endocrinol.. Phenylphenols,. biphenols,. bisphenol-A. and. 4-tert-octylphenol. exhibit. alpha. and. beta.estrogen.activities.and.antiandrogen. activity.in.reporter.cell.lines..193:43.–.49. 80.. Roy. P,. Salminen. H,. Koskimies. P,. Simola. J,. Smeds. A,. Saukko. P,. Huhtaniemi. IT. (2005). J Steroid Biochem Mol Biol.. Screening.of.some.anti-androgenic.endocrine.disruptors.using.a.recombinant.cellbased.in vitro bioassay..88:157.–.166. 81.. Wetherill.YB,.Petra,.C..E.,.Monk,.K..R.,. Puga,.A..and.Knudsen,.K..E..(2002).Mol Cancer Ther..The.xenoestrogen.bisphenol. A.induces.inappropriate.androgen.receptor.activation.and.mitogenesis.in.prostate. adenocarcinoma.cells..1:515.–.524. 82.. Moriyama.K,.Tagami.T,.Akamizu.T,.Usui. T,.Saijo.M,.Kanamoto.N,.Hataya.Y,.Shimatsu.A,. Kuzuya. H,. Nakao. K. (2002). J. Clin Endocrinol Metab..Thyroid.hormone. action.is.disrupted.by.bisphenol.A.as.an. antagonist..87:5185.–.5190. 83.. Jung. KK,. Kim. SY,. Kim. TG,. Kang. JH,. Kang.SY,.Cho.JY,.Kim.SH.(2007).Arch Pharm Res..Differential.regulation.of.thyroid.hormone.receptor-mediated.function. by.endocrine.disruptors..30:616.–.623. 51 84.. Fini.JB,.Le.Mevel.S,.Turque.N,.Palmier.K,. Zalko.D,.Cravedi.JP,.Demeneix.BA.(2007). Environ Sci Technol..An.in vivo.multiwellbased. fluorescent. screen. for. monitoring. vertebrate.thyroid.hormone.disruption..41:. 5908.–.5914. 85.. Ghisari.M,.Bonefeld-Jorgensen.EC.(2005). Mol Cell Endocrinol.. Impact. of. environmental.chemicals.on.the.thyroid.hormone. function. in. pituitary. rat. GH3. cells.. 244:. 31.–.41. 86.. Zoeller. RT,. Bansal. R,. Parris. C. (2005). Endocrinology..Bisphenol-A,.an.environmental.contaminant.that.acts.as.a.thyroid. hormone.receptor.antagonist.in vitro,.increases.serum.thyroxine,.and.alters.RC3/ neurogranin.expression.in.the.developing. rat.brain..146:607.–.612. 87.. Benachour. N,. Moslemi. S,. Sipahutar. H,. Seralini.GE.(2007).Toxicol Appl Pharmacol..Cytotoxic.effects.and.aromatase.inhibition.by.xenobiotic.endocrine.disrupters. alone.and.in.combination..222:129.–.140. 88.. Heindel.JJ,.vom.Saal.FS.(2008).Environ Health Perspect.. Meeting. report:. batchto-batch.variability.in.estrogenic.activity. in. commercial. animal. diets.–.importance. and.approaches.for.laboratory.animal.research..116:389.–.393. 89.. Dolinoy.DC,.Huang.D,.Jirtle.RL.(2007). Proc Natl Acad Sci U S A..Maternal.nutrient.supplementation.counteracts.bisphenol. A-induced. DNA. hypomethylation. in. early.development..104:13056.–.13061. 90.. Calabrese.EJ,.Blain.R.(2005).Toxicol Appl Pharmacol..The.occurrence.of.hormetic. dose.responses.in.the.toxicological.literature,.the.hormesis.database:.an.overview.. 202:289.–.301.
91.. Calabrese.EJ,.Baldwin.LA.(2003).Toxicol Sci..The.hormetic.dose-response.model.is. more. common. than. the. threshold. model. in.toxicology..71:246.–.250. 92.. Taylor. JA,. Welshons. WV,. Vom. Saal. FS. (2008).Reprod Toxicol..No.effect.of.route. of.exposure.(oral;.subcutaneous.injection). on.plasma.bisphenol.A.throughout.24h.after.administration.in.neonatal.female.mice.. 25:169.–.176. 93.. Pottenger.LH,.Domoradzki.JY,.Markham. DA,.Hansen.SC,.Cagen.SZ,.Waechter.JM,. Jr..(2000).Toxicol Sci..The.relative.bioavailability.and.metabolism.of.bisphenol.A.in.rats.is.dependent.upon.the.route.of.administration..54:3.–.18. 94.. Yamasaki. K,. Sawaki. M,. Takatsuki. M. (2000). Environ Health Perspect.. Immature.rat.uterotrophic.assay.of.bisphenol.A.. 108:1147.–.1150. 95.. Kurebayashi. H,. Harada. R,. Stewart. RK,. Numata. H,. Ohno.Y. (2002). Toxicol Sci.. Disposition.of.a.low.dose.of.bisphenol.A. in.male.and.female.cynomolgus.monkeys.. 68:32.–.42. 96.. NTP.(2008).Peer.Review.Report.for.the. NTP.Brief.on.Bisphenol.A.(http://cerhr. niehs.nih.gov/chemicals/bisphenol/bisphenol.html). 97.. NTP. (2001). National. Toxicology. Program’s.Report.of.the.Endocrine.Disruptors. Peer. Review.. (http://ntp.niehs.nih.gov/ntp/ htdocs/liason/LowDosePeerFinalRpt.pdf). 98.. Haseman.JK,.Bailer.AJ,.Kodell.RL,.Morris. R,. Portier. K. (2001). Toxicol Sci.. Statistical.issues.in.the.analysis.of.low-dose. endocrine.disruptor.data..61:201.–.210. 52 99.. Itoh. H,. Iwasaki. M,. Hanaoka. T,. Sasaki. H,. Tanaka. T,. Tsugane. S. (2007). Environ Health Prev Med.. Urinary. bisphenol-A. concentration.in.infertile.japanese.women. and.its.association.with.endometriosis:.A. cross-sectional.study..12:258.–.264. 100..Wolff.M,.Engel.S,.Berkowitz.G,.Ye.X.SM,. Zhu.C,.Wetmur.J,.Calafat.A.(2008).Environ Health Perspect..Prenatal.phenol.and. phthalate. exposures. and. birth. outcomes. 116:1092.–.1097. 101..Takeuchi.T,.Tsutsumi.O.(2002).Biochem Biophys Res Commun.. Serum. bisphenol. A. concentrations. showed. gender. differences,.possibly.linked.to.androgen.levels.. 291:76.–.78. 102..Yang. M,. Kim. SY,. Chang. SS,. Lee. IS,. Kawamoto.T. (2006). Environ Mol Mutagen..Urinary.concentrations.of.bisphenol. A.in.relation.to.biomarkers.of.sensitivity. and. effect. and. endocrine-related. health. effects..47:571.–.578. 103..Sugiura.–.Ogasawara.M,.Ozaki.Y,.Sonta.S,. Makino.T,.Suzumori.K.(2005).Hum Reprod.. Exposure.to.bisphenol.A.is.associated.with. recurrent.miscarriage..20:.2325.–.2329. 104..Yamada.H,.Furuta.I,.Kato.EH,.Kataoka.S,. Usuki.Y,.Kobashi.G,.Sata.F,.Kishi.R,.Fujimoto.S.(2002).Reprod Toxicol..Maternal. serum.and.amniotic.fluid.bishenol.A.concentrations.in.the.early.second.trimester.. 16:735.–.739. 105..Takeuchi.T,.Tsutsumi.O,.Ikezuki.Y,.Takai. Y,. Taketani.Y. (2004). Endocr J.. Positive. relationship.between.androgen.and.the.endocrine.disruptor,.bisphenol.A,.in.normal.women.and.women.with.ovarian.dysfunction..51:165.–.169. nTp brief
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National Toxicology Program U.S. De
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[This page inTenTionally lefT blank
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NTP.will.transmit.the.NTP-CERHR.<st
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National Toxicology Program U.S. De
Page 13 and 14: [This page inTenTionally lefT blank
Page 15 and 16: nTp brief tainers.with.internal.epo
Page 17 and 18: Population Adult General. Populatio
Page 19 and 20: Table 3. Blood and Breast Milk Biom
Page 21 and 22: Figure 2b. The weight of evidence t
Page 23 and 24: in.considering.the.biological.plaus
Page 25 and 26: isphenol.A.as.efficiently.as.adult.
Page 27 and 28: isphenol.A..For.example,.this.raise
Page 29 and 30: laboRaToRy aNImal STudIeS In.contra
Page 31 and 32: of.normal.sex-based.differences.bet
Page 33 and 34: death.(168),.synaptic.plasticity.(1
Page 35 and 36: gland.carcinogen.or.that.bisphenol.
Page 37 and 38: understand.the.possible.long-term.c
Page 39 and 40: strategies.to.improve.the.sensitivi
Page 41 and 42: • • Howdeshell.et.al. (55).repo
Page 43 and 44: and.cystic.endometrial.hyperplasia.
Page 45 and 46: cutaneous. injection. 20 . vom. Saa
Page 47 and 48: are CurrenT exposures To bisphenol
Page 49 and 50: w/day;.95th.percentiles.0.289.-.0.2
Page 51 and 52: nTp ConClusions The.NTP.reached.the
Page 53 and 54: appendix a: inTerpreTaTion of blood
Page 55 and 56: µg/kg.bw/day.based.on.the.assumpti
Page 57 and 58: concentrations.from.maternal,.fetal
Page 59 and 60: 12.. Padmanabhan. V,. Siefert. K,.
Page 61 and 62: In..Research.Triangle.Park,.NC:.RTI
Page 63: 65.. Alonso-Magdalena. P,. Laribi.
Page 67 and 68: Thyroid.Function.in.Juvenile.Female
Page 69 and 70: droxylase.immunoreactivity..76:423.
Page 71 and 72: stanceschimiques.gc.ca/challenge-de
Page 73 and 74: Watanabe.H,.Ohta.Y,.Iguchi.T.(2006)
Page 75 and 76: 226..vom. Saal. FS,. Cooke. PS,. Bu
Page 77 and 78: solid.phase.extraction-high.perform
Page 79 and 80: appendix i. nTp-Cerhr bisphenol a e
Page 81 and 82: 158 CHAPIN ET AL. the CERHR Core Co
Page 83 and 84: 160 CHAPIN ET AL. referred to as 4,
Page 85 and 86: 162 CHAPIN ET AL. concentrations in
Page 87 and 88: 164 CHAPIN ET AL. Food (no. sampled
Page 89 and 90: 166 CHAPIN ET AL. Table 6 Continued
Page 91 and 92: 168 CHAPIN ET AL. comparison of the
Page 93 and 94: 170 CHAPIN ET AL. Table 8 Urinary C
Page 95 and 96: 172 CHAPIN ET AL. the blood of male
Page 97 and 98: 174 CHAPIN ET AL. Table 11 Bispheno
Page 99 and 100: 176 CHAPIN ET AL. Table 13 Summarie
Page 101 and 102: 178 CHAPIN ET AL. Table 15 Estimate
Page 103 and 104: 180 CHAPIN ET AL. Table 17 Maximum
Page 105 and 106: 182 CHAPIN ET AL. 2.0 GENERAL TOXIC
Page 107 and 108: 184 CHAPIN ET AL. fetuses (3.572.7
Page 109 and 110: 186 CHAPIN ET AL. Secondary sources
Page 111 and 112: 188 CHAPIN ET AL. Table 25 Maternal
Page 113 and 114: 190 CHAPIN ET AL. Table 27 Bispheno
Page 115 and 116:
192 CHAPIN ET AL. Table 31 Qualitat
Page 117 and 118:
194 CHAPIN ET AL. Table 33 Toxicoki
Page 119 and 120:
Page 121 and 122:
198 CHAPIN ET AL. appeared to occur
Page 123 and 124:
200 CHAPIN ET AL. Table 43 Biliary
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202 CHAPIN ET AL. suggesting that 4
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204 CHAPIN ET AL. low following ora
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206 CHAPIN ET AL. scaling and speci
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208 CHAPIN ET AL. 60-100% in each d
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210 CHAPIN ET AL. related. No histo
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212 CHAPIN ET AL. Table 52 Continue
Page 137 and 138:
214 CHAPIN ET AL. Model and exposur
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216 CHAPIN ET AL. Model and exposur
Page 141 and 142:
218 Model and exposure Husbandry a
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220 CHAPIN ET AL. Table 54 Differen
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222 CHAPIN ET AL. Table 56 Anti-And
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224 Table 57 In Vitro Genetic Toxic
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226 CHAPIN ET AL. Table 58 In Vivo
Page 151 and 152:
228 CHAPIN ET AL. Table 59 Developm
Page 153 and 154:
Page 155 and 156:
232 CHAPIN ET AL. Table 64 Tissue R
Page 157 and 158:
Page 159 and 160:
236 CHAPIN ET AL. treatment conditi
Page 161 and 162:
238 CHAPIN ET AL. clinical signs, b
Page 163 and 164:
240 CHAPIN ET AL. Table 71 Benchmar
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242 CHAPIN ET AL. group, 5 from 1 l
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244 CHAPIN ET AL. least significant
Page 169 and 170:
246 CHAPIN ET AL. group was a reduc
Page 171 and 172:
248 CHAPIN ET AL. 100-151 g for fem
Page 173 and 174:
250 CHAPIN ET AL. 3.2.3.2 Developme
Page 175 and 176:
252 CHAPIN ET AL. weights, bispheno
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254 CHAPIN ET AL. 120 mg/kg bw/day
Page 179 and 180:
256 CHAPIN ET AL. comparisons condu
Page 181 and 182:
258 CHAPIN ET AL. the findings of t
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260 CHAPIN ET AL. analyzed.] Anogen
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262 CHAPIN ET AL. purposeful confou
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264 CHAPIN ET AL. increased lordosi
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266 CHAPIN ET AL. that there was a
Page 191 and 192:
268 CHAPIN ET AL. duration of adver
Page 193 and 194:
270 CHAPIN ET AL. doses of potent e
Page 195 and 196:
272 CHAPIN ET AL. Table 74 Effects
Page 197 and 198:
274 CHAPIN ET AL. reproductive orga
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276 CHAPIN ET AL. tyrosine-hydroxly
Page 201 and 202:
278 CHAPIN ET AL. include small sam
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280 CHAPIN ET AL. males/group. [It
Page 205 and 206:
282 CHAPIN ET AL. termination, whic
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284 CHAPIN ET AL. provided a reliab
Page 209 and 210:
286 CHAPIN ET AL. grooming, and out
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288 CHAPIN ET AL. method of oral do
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290 CHAPIN ET AL. reared by their d
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292 CHAPIN ET AL. has been informed
Page 217 and 218:
294 CHAPIN ET AL. buffered paraform
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296 CHAPIN ET AL. unit. Further, th
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298 CHAPIN ET AL. PND 21 and housed
Page 223 and 224:
300 CHAPIN ET AL. Tando et al. (200
Page 225 and 226:
302 CHAPIN ET AL. Purina Certified
Page 227 and 228:
304 CHAPIN ET AL. high-doses of bis
Page 229 and 230:
306 CHAPIN ET AL. born to those dam
Page 231 and 232:
308 CHAPIN ET AL. average weight we
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310 CHAPIN ET AL. study authors con
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312 CHAPIN ET AL. used for extracti
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314 CHAPIN ET AL. jar, and there we
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316 CHAPIN ET AL. of testes and com
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318 CHAPIN ET AL. differentiation o
Page 243 and 244:
320 CHAPIN ET AL. Table 81 Summary
Page 245 and 246:
322 CHAPIN ET AL. Table 82 Continue
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Page 249 and 250:
Page 251 and 252:
328 CHAPIN ET AL. 600 mg/kg bw/day)
Page 253 and 254:
330 CHAPIN ET AL. (Nagao et al., 19
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332 CHAPIN ET AL. antinuclear antib
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334 CHAPIN ET AL. least 6 animals.
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336 CHAPIN ET AL. Utility (Adequacy
Page 261 and 262:
338 CHAPIN ET AL. stomach weight wa
Page 263 and 264:
340 CHAPIN ET AL. Schirling et al.
Page 265 and 266:
342 CHAPIN ET AL. Endpoint Table 88
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344 CHAPIN ET AL. different diets b
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346 CHAPIN ET AL. with 40 mg vitami
Page 271 and 272:
348 CHAPIN ET AL. the bisphenol A v
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350 CHAPIN ET AL. and determining t
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352 CHAPIN ET AL. expression [to B6
Page 277 and 278:
354 CHAPIN ET AL. indicated] at 0 (
Page 279 and 280:
356 CHAPIN ET AL. concentrations us
Page 281 and 282:
358 CHAPIN ET AL. animals were non-
Page 283 and 284:
360 CHAPIN ET AL. following adjustm
Page 285 and 286:
362 CHAPIN ET AL. Table 94 Treatmen
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364 CHAPIN ET AL. Table 97 Effects
Page 289 and 290:
366 CHAPIN ET AL. Table 99 Treatmen
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368 CHAPIN ET AL. Therefore the NTP
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370 CHAPIN ET AL. weeks before mati
Page 295 and 296:
Page 297 and 298:
374 Table 101 Summary of High Utili
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376 Table 102 Summary of Limited Ut
Page 301 and 302:
Page 303 and 304:
380 CHAPIN ET AL. from other suppli
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382 CHAPIN ET AL. U.S. populations.
Page 307 and 308:
384 CHAPIN ET AL. 10. Critical desi
Page 309 and 310:
386 CHAPIN ET AL. Engel SM, Levy B,
Page 311 and 312:
388 CHAPIN ET AL. alpha and beta ex
Page 313 and 314:
390 CHAPIN ET AL. Murray TJ, Maffin
Page 315 and 316:
392 CHAPIN ET AL. Ryan BC, Vandenbe
Page 317 and 318:
394 CHAPIN ET AL. Thomas P, Dong J.
Page 319 and 320:
Page 321:
appendix iii. publiC CommenTs and p
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