Monograph on the Potential Human Reproductive and ... - OEHHA

BISPHENOL A
Table 4
Continued
Bisphenol A concentration in
Sample (location) Procedure simulant Reference
(residual bisphenol A at 10% ethanol, or Migloyl at 491C for 6–
8800 to 11,200 mg/kg)
from U.S. manufacturers
240 hr
2 infant bottles from Japan In three repeated tests, boiling water was Below quantification limit (LOD Sun et al.
added to bottles; bottles were incubated 0.57 ppb [lg/L]) to mean (2000)
at 951C for 30 min and cooled to room concentrations of 0.75 ppb before
temperature; before repeating the test a brushing and o0.57 to 0.18 ppb
fourth time, the bottles were scrubbed
with a brush
after brushing.
4 new different brands of Bottles were exposed to distilled water, 1.1–2.5 ppb [lg/L]. D’Antuono
infant bottles (Argentina) 3% acetic acid, or 15% ethanol at 801C
for 2 min or distilled water at 1001C for
0.5 min
et al. (2001)
12 infant bottles (Norway) Bottles were tested before washing and Mean (range) mg/L [ppb]: 0 washes: Brede et al.
following 51 and 169 dish washings; 0.23 (0.11–0.43) 51 washes: 8.4 (3.7– (2003)
bottles were occasionally brushed (13
times by second test and 23 times by
third test) and boiled (12 times by
second testing and 25 times by third
testing); unwashed bottles were rinsed
with boiling water before testing; for
testing, bottles were filled with hot
water and incubated at 1001C for 1 hr
17) 169 washes: 6.7 (2.5–15)
18 infant bottles (12 tested) Bottles were tested before and after 20 and Before washing: ND (LOD 1.1 ppb CSL (2004)
(U.K.) 50 dish washings; bottles were brushed or mg/L) in 10% ethanol and ND
after every 2 wash cycles; bottles were (LOD 0.34 ppb or mg/L) in 3%
sterilized with boiling water, filled with acetic acid; 20 washes: ND to
3% acetic acid, or 10% ethanol, and 4.5 ppb in 10% ethanol and ND to
incubated at 701C for 1 hr 0.51 ppb in 3% acetic acid; 50
washes: ND to 3.1 ppb in 10%
ethanol and ND to 0.7 ppb in 3%
acetic acid
28 brands of new infant Bottles were cut and pieces were exposed ND (LOD 0.05) to 1.92 mg/in 2 [o5– Onn Wong
bottles (residual to 10% ethanol at 701C or corn oil at 192 lg/L or ppb] in 10% ethanol et al. (2005)
bisphenol A 1001C for 8–240 hr and ND (LOD 0.05) to 6.54 mg/in 2
concentrations of o3 to [o5–654 lg/L] in corn oil over the
141 mg/kg)
manufactured in Europe
or Asia (Singapore)
240-hr exposure period
22 new infant bottles and 20 Bottles were immersed in boiling water ND in new bottles (o2.5 mg/L (LOD) FCPSA (2005)
used (3–36 months) for 10 min before testing and filled with [ppb] in distilled water and
bottles (Netherlands) distilled water or 3% acetic acid and o3.9 mg/L (LOD) in 3% acetic
incubated at 40 1C for 24 hr acid) or in used bottles exposed to
3% acetic acid; not detected to nonquantifiable
(o5 mg/L) in distilled
water from used bottles.
New unwashed infant Bottles were exposed to water at 951C for ND (LOD 0.05 mg/L [ppb]) to Japanese
bottles (number not 30 min 3.9 mg/L. studies
indicated) (Japan) reviewed
in
Miyamoto
and Kotake
(2006)
5-gallon water carboys Water was stored in the carboys for 3, 12, 0.1–0.5 mg/L [ppb] at 3 and 12 weeks Biles et al.
or 39 weeks, temperature not indicated and. 4.6–4.7 mg/L at 39 weeks c
(1997b)
a Reviewed by European Union (2003).
b Reviewed by Haighton et al. (2002).
c The authors of this study identified an error in the units reported in their study and that the correct concentrations are 1000-fold higher
than indicated in the article, the correct values are indicated in table above (T. Begley, email communication, August 6, 2007).
ND, not detected.
Kawamura et al., 1999; Haighton et al., 2002; European exposed to products that had been recalled because of
Union, 2003). One study (Kawamura et al., 1999) showed unacceptable residual concentrations of bisphenol A and
higher concentrations of bisphenol A in simulants other compounds. The study by Biles et al. (1997b)
Birth Defects Research (Part B) 83:157–395, 2008
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