Monograph on the Potential Human Reproductive and ... - OEHHA

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nTp brief 186..Russo.J,.Gusterson.BA,.Rogers.AE,.Russo. IH,.Wellings.SR,.van.Zwieten.MJ.(1990). Lab Invest.. Comparative. study. of. human.and.rat.mammary.tumorigenesis..62:. 244.–.278. 187..Thayer. KA,. Foster. PM. (2007). Environ Health Perspect.. Workgroup. Report:. National.Toxicology.Program.workshop. on.hormonally.induced.reproductive.tumors-relevance.of.rodent.bioassays..115:. 1351.–.1356. [see. also. http://ntp.niehs.nih. gov/go/18592]. 188..Fitzgibbons. PL,. Henson. DE,. Hutter. RV. (1998). Arch Pathol Lab Med.. Benign. breast.changes.and.the.risk.for.subsequent. breast.cancer:.an.update.of.the.1985.consensus. statement.. Cancer. Committee. of. the.College.of.American.Pathologists..122:. 1053.–.1055. 189..Honma.S,.Suzuki.A,.Buchanan.DL,.Katsu. Y,. Watanabe. H,. Iguchi. T. (2002). Reprod Toxicol..Low.dose.effect.of.in utero.exposure.to.bisphenol.A.and.diethylstilbestrol. on. female. mouse. reproduction.. 16:. 117.–.122. 190..Suzuki. A,. Sugihara. A,. Uchida. K,. Sato. T,. Ohta.Y,. Katsu.Y,.Watanabe. H,. Iguchi. T.(2002).Reprod Toxicol..Developmental. effects.of.perinatal.exposure.to.bisphenol- A. and. diethylstilbestrol. on. reproductive. organs.in.female.mice..16:107.–.116. 191..Keri.RA,.Ho.SM,.Hunt.PA,.Knudsen.KE,. Soto.AM,.Prins.GS.(2007).Reprod Toxicol.. An. evaluation. of. evidence. for. the. carcinogenic.activity.of.bisphenol.A..24:. 240.–.252. 192..Wang.S,.Garcia.AJ,.Wu.M,.Lawson.DA,. Witte.ON,.Wu.H.(2006).Proc Natl Acad Sci USA.. Pten. deletion. leads. to. the. ex- 59 pansion.of.a.prostatic.stem/progenitor.cell. subpopulation.and.tumor.initiation..103:. 1480.–.1485. 193..Ichihara.T,.Yoshino.H,.Imai.N,.Tsutsumi. T,.Kawabe.M,.Tamano.S,.Inaguma.S,.Suzuki.S,.Shirai.T.(2003).J Toxicol Sci..Lack. of.carcinogenic.risk.in.the.prostate.with. transplacental.and.lactational.exposure.to. bisphenol.A.in.rats..28:165.–.171. 194..Richter. CA,. Taylor. JA,. Ruhlen. RL,. Welshons.WV,.Vom. Saal. FS. (2007). Environ Health Perspect..Estradiol.and.bisphenol.A.stimulate.androgen.receptor.and. estrogen.receptor.gene.expression.in.fetal. mouse.prostate.mesenchyme.cells..115:. 902.–.908. 195..Ogura. Y,. Ishii. K,. Kanda. H,. Kanai. M,. Arima.K,.Wang.Y,.Sugimura.Y.(2007).Differentiation..Bisphenol.A.induces.permanent.squamous.change.in.mouse.prostatic. epithelium..75:745.–.756. 196..Gupta.C.(2000).Proc Soc Exp Biol Med.. Reproductive. malformation. of. the. male. offspring.following.maternal.exposure.to. estrogenic.chemicals..224:61.–.68. 197..Ashby. J,. Tinwell. H,. Haseman. J. (1999). Regul Toxicol Pharmacol..Lack.of.effects. for. low. dose. levels. of. bisphenol.A. and. diethylstilbestrol.on.the.prostate.gland.of. CF1.mice.exposed.in utero..30:156.–.166. 198..Cagen.SZ,.Waechter.JM,.Jr.,.Dimond.SS,. Breslin.WJ,. Butala. JH,. Jekat. FW,. Joiner. RL,. Shiotsuka. RN,. Veenstra. GE,. Harris. LR.(1999).Regul Toxicol Pharmacol..Normal. reproductive. organ. development. in. Wistar.rats.exposed.to.bisphenol.A.in.the. drinking.water..30:130.–.139. 199..Kato.H,.Furuhashi.T,.Tanaka.M,.Katsu.Y,.
Watanabe.H,.Ohta.Y,.Iguchi.T.(2006).Reprod Toxicol..Effects.of.bisphenol.A.given. neonatally. on. reproductive. functions. of. male.rats..22:20.–.19. 200..Howdeshell. KL,. Furr. J,. Lambright. CR,. Wilson.VS,.Ryan.BC,.Gray.LE,.Jr..(2008). Toxicol Sci.. Gestational. and. lactational. exposure.to.ethinyl.estradiol,.but.not.bisphenol.A,.decreases.androgen-dependent.reproductive.organ.weights.and.epididymal.sperm.abundance.in.the.male.Long. Evans.Hooded.rat..102:371.–.382. 201..Nagao.T,.Saito.Y,.Usumi.K,.Yoshimura.S,. Ono.H.(2002).Reprod Toxicol..Low-dose. bisphenol.A.does.not.affect.reproductive. organs. in. estrogen-sensitive. C57BL/6N. mice.exposed.at.the.sexually.mature,.juvenile,.or.embryonic.stage..16:123.–.130. 202..Milman. HA,. Bosland. MC,. Walden. PD,. Heinze.JE.(2002).Regul Toxicol Pharmacol..Evaluation.of.the.adequacy.of.published.studies.of.low-dose.effects.of.bisphenol.A.on.the.rodent.prostate.for.use.in. human.risk.assessment..35:338.–.346. 203..Ramos.JG,.Varayoud.J,.Kass.L,.Rodriguez. H,.Costabel.L,.Munoz-De-Toro.M,.Luque. EH. (2003). Endocrinology.. Bisphenol. A. induces.both.transient.and.permanent.histofunctional. alterations. of. the. hypothalamic-pituitary-gonadal.axis.in.prenatally. exposed.male.rats..144:3206.–.3215. 204..Golub. MS,. Collman. GW,. Foster. PM,. Kimmel.CA,.Rajpert-De.Meyts.E,.Reiter. EO,.Sharpe.RM,.Skakkebaek.NE,.Toppari. J.(2008).Pediatrics..Public.health.implications.of.altered.puberty.timing..121.Suppl. 3:S218.–.230. 205..Trichopoulos. D,. Adami. HO,. Ekbom. A,. Hsieh.CC,.Lagiou.P.(2008).Int J Cancer.. 60 Early.life.events.and.conditions.and.breast. cancer.risk:.from.epidemiology.to.etiology.. 122:481.–.485. 206..Partsch.CJ,.Sippell.WG.(2001).Hum ReprodUpdate..Pathogenesis.and.epidemiology. of. precocious. puberty.. Effects. of. exogenous.oestrogens..7:292.–.302. 207..Yoshida. M,.Shimomoto.T,.Katashima.S,. Watanabe.G,.Taya.K,.Maekawa.A.(2004). J Reprod Dev..Maternal.exposure.to.low. doses. of. bisphenol. A. has. no. effects. on. development.of.female.reproductive.tract. and.uterine.carcinogenesis.in.Donryu.rats.. 50:349.–.360. 208..Cooper.RL,.Goldman,.J.M.,.Vandenbergh,. J.G..(1993).Monitoring.of.the.estrous.cycle. in.the.laboratory.rodent.by.vaginal.lavage.. In:.Heindel,.J.J.,.Chapin,.R.E..(Eds.),.Female. Reproductive.Toxicology.. Methods Toxicol.,. Vol.. 3B.. Academic. Press,. pp.. 45–56. 209..Ryan.BC,.Vandenbergh.JG.(2002).Neurosci Biobehav Rev..Intrauterine.position.effects..26:665.–.678. 210..Tyl.RW,.Myers.CB,.Marr.MC,.Sloan.CS,. Castillo.NP,.Veselica.MM,.Seely.JC,.Dimond. SS,.Van. Miller. JP,. Shiotsuka. RS,. Stropp.GD,.Waechter.JM,.Jr.,.Hentges.SG. (2008). Toxicol Sci.. Two-generation. reproductive.toxicity.evaluation.of.dietary. 17beta-estradiol.(E2;.CAS.No..50.–.28.–.2). in.CD-1.(Swiss).mice..102:392.–.412. 211..Vandenbergh.JG.(1989).J Anim Sci..Coordination. of. social. signals. and. ovarian. function.during.sexual.development..67:. 1841.–.1847. 212..Schank.JC,.Alberts.JR.(2000).Horm Behav.. Effects.of.male.rat.urine.on.reproductive. nTp brief
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National Toxicology Program U.S. De
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[This page inTenTionally lefT blank
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NTP.will.transmit.the.NTP-CERHR.<st
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National Toxicology Program U.S. De
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nTp brief tainers.with.internal.epo
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Population Adult General. Populatio
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Table 3. Blood and Breast Milk Biom
Page 21 and 22: Figure 2b. The weight of evidence t
Page 23 and 24: in.considering.the.biological.plaus
Page 25 and 26: isphenol.A.as.efficiently.as.adult.
Page 27 and 28: isphenol.A..For.example,.this.raise
Page 29 and 30: laboRaToRy aNImal STudIeS In.contra
Page 31 and 32: of.normal.sex-based.differences.bet
Page 33 and 34: death.(168),.synaptic.plasticity.(1
Page 35 and 36: gland.carcinogen.or.that.bisphenol.
Page 37 and 38: understand.the.possible.long-term.c
Page 39 and 40: strategies.to.improve.the.sensitivi
Page 41 and 42: • • Howdeshell.et.al. (55).repo
Page 43 and 44: and.cystic.endometrial.hyperplasia.
Page 45 and 46: cutaneous. injection. 20 . vom. Saa
Page 47 and 48: are CurrenT exposures To bisphenol
Page 49 and 50: w/day;.95th.percentiles.0.289.-.0.2
Page 51 and 52: nTp ConClusions The.NTP.reached.the
Page 53 and 54: appendix a: inTerpreTaTion of blood
Page 55 and 56: µg/kg.bw/day.based.on.the.assumpti
Page 57 and 58: concentrations.from.maternal,.fetal
Page 59 and 60: 12.. Padmanabhan. V,. Siefert. K,.
Page 61 and 62: In..Research.Triangle.Park,.NC:.RTI
Page 63 and 64: 65.. Alonso-Magdalena. P,. Laribi.
Page 65 and 66: 91.. Calabrese.EJ,.Baldwin.LA.(2003
Page 67 and 68: Thyroid.Function.in.Juvenile.Female
Page 69 and 70: droxylase.immunoreactivity..76:423.
Page 71: stanceschimiques.gc.ca/challenge-de
Page 75 and 76: 226..vom. Saal. FS,. Cooke. PS,. Bu
Page 77 and 78: solid.phase.extraction-high.perform
Page 79 and 80: appendix i. nTp-Cerhr bisphenol a e
Page 81 and 82: 158 CHAPIN ET AL. the CERHR Core Co
Page 83 and 84: 160 CHAPIN ET AL. referred to as 4,
Page 85 and 86: 162 CHAPIN ET AL. concentrations in
Page 87 and 88: 164 CHAPIN ET AL. Food (no. sampled
Page 89 and 90: 166 CHAPIN ET AL. Table 6 Continued
Page 91 and 92: 168 CHAPIN ET AL. comparison of the
Page 93 and 94: 170 CHAPIN ET AL. Table 8 Urinary C
Page 95 and 96: 172 CHAPIN ET AL. the blood of male
Page 97 and 98: 174 CHAPIN ET AL. Table 11 Bispheno
Page 99 and 100: 176 CHAPIN ET AL. Table 13 Summarie
Page 101 and 102: 178 CHAPIN ET AL. Table 15 Estimate
Page 103 and 104: 180 CHAPIN ET AL. Table 17 Maximum
Page 105 and 106: 182 CHAPIN ET AL. 2.0 GENERAL TOXIC
Page 107 and 108: 184 CHAPIN ET AL. fetuses (3.572.7
Page 109 and 110: 186 CHAPIN ET AL. Secondary sources
Page 111 and 112: 188 CHAPIN ET AL. Table 25 Maternal
Page 113 and 114: 190 CHAPIN ET AL. Table 27 Bispheno
Page 115 and 116: 192 CHAPIN ET AL. Table 31 Qualitat
Page 117 and 118: 194 CHAPIN ET AL. Table 33 Toxicoki
Page 119 and 120: 196 CHAPIN ET AL. Table 36 Toxicoki
Page 121 and 122: 198 CHAPIN ET AL. appeared to occur
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200 CHAPIN ET AL. Table 43 Biliary
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202 CHAPIN ET AL. suggesting that 4
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204 CHAPIN ET AL. low following ora
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206 CHAPIN ET AL. scaling and speci
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208 CHAPIN ET AL. 60-100% in each d
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210 CHAPIN ET AL. related. No histo
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212 CHAPIN ET AL. Table 52 Continue
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214 CHAPIN ET AL. Model and exposur
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216 CHAPIN ET AL. Model and exposur
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218 Model and exposure Husbandry a
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220 CHAPIN ET AL. Table 54 Differen
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222 CHAPIN ET AL. Table 56 Anti-And
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224 Table 57 In Vitro Genetic Toxic
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226 CHAPIN ET AL. Table 58 In Vivo
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228 CHAPIN ET AL. Table 59 Developm
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230 CHAPIN ET AL. Table 62 Toxicoki
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232 CHAPIN ET AL. Table 64 Tissue R
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234 CHAPIN ET AL. Table 68 Toxicoki
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236 CHAPIN ET AL. treatment conditi
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238 CHAPIN ET AL. clinical signs, b
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240 CHAPIN ET AL. Table 71 Benchmar
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242 CHAPIN ET AL. group, 5 from 1 l
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244 CHAPIN ET AL. least significant
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246 CHAPIN ET AL. group was a reduc
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248 CHAPIN ET AL. 100-151 g for fem
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250 CHAPIN ET AL. 3.2.3.2 Developme
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252 CHAPIN ET AL. weights, bispheno
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254 CHAPIN ET AL. 120 mg/kg bw/day
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256 CHAPIN ET AL. comparisons condu
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258 CHAPIN ET AL. the findings of t
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260 CHAPIN ET AL. analyzed.] Anogen
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262 CHAPIN ET AL. purposeful confou
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264 CHAPIN ET AL. increased lordosi
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266 CHAPIN ET AL. that there was a
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268 CHAPIN ET AL. duration of adver
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270 CHAPIN ET AL. doses of potent e
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272 CHAPIN ET AL. Table 74 Effects
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274 CHAPIN ET AL. reproductive orga
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276 CHAPIN ET AL. tyrosine-hydroxly
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278 CHAPIN ET AL. include small sam
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280 CHAPIN ET AL. males/group. [It
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282 CHAPIN ET AL. termination, whic
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284 CHAPIN ET AL. provided a reliab
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286 CHAPIN ET AL. grooming, and out
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288 CHAPIN ET AL. method of oral do
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290 CHAPIN ET AL. reared by their d
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292 CHAPIN ET AL. has been informed
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294 CHAPIN ET AL. buffered paraform
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296 CHAPIN ET AL. unit. Further, th
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298 CHAPIN ET AL. PND 21 and housed
Page 223 and 224:
300 CHAPIN ET AL. Tando et al. (200
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302 CHAPIN ET AL. Purina Certified
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304 CHAPIN ET AL. high-doses of bis
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306 CHAPIN ET AL. born to those dam
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308 CHAPIN ET AL. average weight we
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310 CHAPIN ET AL. study authors con
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312 CHAPIN ET AL. used for extracti
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314 CHAPIN ET AL. jar, and there we
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316 CHAPIN ET AL. of testes and com
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318 CHAPIN ET AL. differentiation o
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320 CHAPIN ET AL. Table 81 Summary
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322 CHAPIN ET AL. Table 82 Continue
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328 CHAPIN ET AL. 600 mg/kg bw/day)
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330 CHAPIN ET AL. (Nagao et al., 19
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332 CHAPIN ET AL. antinuclear antib
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334 CHAPIN ET AL. least 6 animals.
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336 CHAPIN ET AL. Utility (Adequacy
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338 CHAPIN ET AL. stomach weight wa
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340 CHAPIN ET AL. Schirling et al.
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342 CHAPIN ET AL. Endpoint Table 88
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344 CHAPIN ET AL. different diets b
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346 CHAPIN ET AL. with 40 mg vitami
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348 CHAPIN ET AL. the bisphenol A v
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350 CHAPIN ET AL. and determining t
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352 CHAPIN ET AL. expression [to B6
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354 CHAPIN ET AL. indicated] at 0 (
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356 CHAPIN ET AL. concentrations us
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358 CHAPIN ET AL. animals were non-
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360 CHAPIN ET AL. following adjustm
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362 CHAPIN ET AL. Table 94 Treatmen
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364 CHAPIN ET AL. Table 97 Effects
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366 CHAPIN ET AL. Table 99 Treatmen
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368 CHAPIN ET AL. Therefore the NTP
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370 CHAPIN ET AL. weeks before mati
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374 Table 101 Summary of High Utili
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376 Table 102 Summary of Limited Ut
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Page 303 and 304:
380 CHAPIN ET AL. from other suppli
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382 CHAPIN ET AL. U.S. populations.
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384 CHAPIN ET AL. 10. Critical desi
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386 CHAPIN ET AL. Engel SM, Levy B,
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388 CHAPIN ET AL. alpha and beta ex
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390 CHAPIN ET AL. Murray TJ, Maffin
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392 CHAPIN ET AL. Ryan BC, Vandenbe
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394 CHAPIN ET AL. Thomas P, Dong J.
Page 319 and 320:
Page 321:
appendix iii. publiC CommenTs and p
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