Monograph on the Potential Human Reproductive and ... - OEHHA

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nTp brief cessing.Aids.and.Materials.in.Contact.with. Food.on.a.request.from.the.Commission.related.to.2,2-bis(4-hydroxyphenyl).propane. (bisphenol. A).. http://www.efsa.europa. eu/EFSA/efsa_locale-1178620753812_ 1178620772817.htm. 26.. European-Commission. (2002). Opinion. of. the.Scientific.Committee.on.Food.on.Bisphenol.A..http://europa.eu.int/comm/food/ fs/sc/scf/out128_en.pdf. 27.. European-Union. (2003). Risk.Assessment. Report.–.4,4’-isopropylidenediphenol.(Bisphenol.A).. http://ecb.jrc.it/DOCUMENTS/ Existing-Chemicals/RISK_ASSESSMENT/ REPORT/bisphenolareport325.pdf. 28.. Sun. Y,. Irie. M,. Kishikawa. N,. Wada. M,. Kuroda.N,.Nakashima.K.(2004).Biomed Chromatogr..Determination.of.bisphenol. A.in.human.breast.milk.by.HPLC.with.column-switching.and.fluorescence.detection.. 18:501.–.507. 29.. Wilson. NK,. Chuang. JC,. Lyu. C,. Menton. R,. Morgan. MK. (2003). J Expo Anal Environ Epidemiol.. Aggregate. exposures. of. nine.preschool.children.to.persistent.organic.pollutants.at.day.care.and.at.home..13:. 187.–.202. 30.. Miyamoto. K,. Kotake. M. (2006). Environ Sci..Estimation.of.daily.bisphenol.A.intake. of.Japanese.individuals.with.emphasis.on. uncertainty.and.variability..13:15.–.29. 31.. Thomson.BM,.Grounds.PR.(2005).Food Addit Contam.. Bisphenol. A. in. canned. foods.in.New.Zealand:.an.exposure.assessment..22:65.–.72. 32.. Hanaoka.T,. Kawamura. N,. Hara. K,.Tsugane.S.(2002).Occup Environ Med..Urinary. bisphenol. A. and. plasma. hormone. 47 concentrations. in. male. workers. exposed. to.bisphenol.A.diglycidyl.ether.and.mixed. organic.solvents..59:625.–.628. 33.. US.EPA.(1988).Recommendations.and.documentation.of.biological.values.for.use.in. risk. assessment.. http://www.epa.gov/iris/ backgr-d.htm. 34.. Brenn-Struckhofova. Z,. Cichna-Markl. M. (2006).Food Addit Contam..Determination. of.bisphenol.A.in.wine.by.sol-gel.immunoaffinity.chromatography,.HPLC.and.fluorescence.detection..23:1227.–.1235. 35.. LaKind.JS,.Naiman.DQ.(2008).bisphenol. A.(Bisphenol.A).daily.intakes.in.the.United.States:.Estimates.from.the.2003.–.2004. NHANES.urinary.bisphenol.A.data..J Expos Sci Environ Epidemiol..In.Press. 36.. Kim.JC,.Shin.HC,.Cha.SW,.Koh.WS,.Chung. MK,.Han.SS.(2001).Life Sci. Evaluation. of.developmental.toxicity.in.rats.exposed. to.the.environmental.estrogen.bisphenol.A. during.pregnancy..69:.2611.–.2625. 37.. Tyl.RW,.Myers.CB,.Marr.MC,.Thomas.BF,. Keimowitz.AR,.Brine.DR,.Veselica.MM,. Fail.PA,.Chang.TY,.Seely.JC,.Joiner.RL,. Butala.JH,.Dimond.SS,.Cagen.SZ,.Shiotsuka.RN,.Stropp.GD,.Waechter.JM.(2002). Toxicol Sci..Three-generation.reproductive. toxicity. study. of. dietary. bisphenol.A. in. CD.Sprague-Dawley.rats..68:121.–.146. 38.. Morrissey. RE,. George. JD,. Price. CJ,. Tyl. RW,.Marr.MC,.Kimmel.CA.(1987).Fundam Appl Toxico..The.Developmental.Toxicity.of.bisphenol.A.in.Rats.and.Mice..8:. 571.–.582. 39.. Tyl.R,.Myers.CB,.Marr.MC..Abbreviated. one-generation.study.of.dietary.bisphenol. A.(Bisphenol.A).in.CD-1®.(Swiss).mice..
In..Research.Triangle.Park,.NC:.RTI.(sponsored.by.the.Society.of.the.Plastics.Industry,.Inc.);.2002. 40.. NTP.(1985).Bisphenol.A:.reproduction.and. fertility. assessment. in. CD-1. mice. when. administered.in.the.feed..NTP-85-192..Research.Triangle.Park,.NC. 41.. Tyl.RW,.Myers.CB,.Marr.MC,.Sloan.CS,. Castillo.NP,.Veselica.MM,.Seely.JC,.Dimond. SS,. Van. Miller. JP,. Shiotsuka. RN,. Beyer. D,. Hentges. SG,. Waechter. JM,. Jr.. (2008).Toxicol Sci..Two-generation.reproductive.toxicity.study.of.dietary.bisphenol. A.(Bisphenol.A).in.CD-1(R).(Swiss).mice.. 104:362.–.384. 42.. Tan.BL,.Kassim.NM,.Mohd.MA.(2003). Toxicol Lett..Assessment.of.pubertal.development. in. juvenile. male. rats. after. subacute.exposure.to.bisphenol.A.and.nonylphenol..143:261.–.270. 43.. Tinwell.H,.Haseman.J,.Lefevre.PA,.Wallis.N,.Ashby.J.(2002).Toxicol Sci..Normal. sexual.development.of.two.strains.of.rat. exposed.in utero.to.low.doses.of.bisphenol. A..68:339.–.348. 44.. Palanza. PL,. Howdeshell. KL,. Parmigiani. S,.vom.Saal.FS.(2002).Environ Health Perspect..Exposure.to.a.low.dose.of.bisphenol. A.during.fetal.life.or.in.adulthood.alters. maternal.behavior.in.mice..110:415.–.422. 45.. Laviola.G,.Gioiosa.L,.Adriani.W,.Palanza. P.(2005) Brain Res Bull..D-Amphetaminerelated. reinforcing. effects. are. reduced. in. mice.exposed.prenatally.to.estrogenic.endocrine.disruptors..65:235.–.240. 46.. Gioiosa.L,.Fissore.E,.Ghirardelli.G,.Parmigiani.S,.Palanza.P.(2007).Horm Behav.. Developmental.exposure.to.low-dose.estro- 48 genic.endocrine.disruptors.alters.sex.differences.in.exploration.and.emotional.responses.in.mice..52:307.–.316. 47.. Ceccarelli. I,. Della. Seta. D,. Fiorenzani. P,. Farabollini.F,.Aloisi.AM.(2007).NeurotoxicolTeratol..Estrogenic.chemicals.at.puberty.change.ERalpha.in.the.hypothalamus.of. male.and.female.rats..29:108.–.115. 48.. Ryan.BC,.Vandenbergh.JG.(2006).Horm Behav.. Developmental. exposure. to. environmental.estrogens.alters.anxiety.and.spatial.memory.in.female.mice..50:85.–.93. 49.. Della. Seta. D,. Minder. I,. Belloni. V,. Aloisi.AM,. Dessi-Fulgheri. F,. Farabollini. F. (2006).Horm Behav..Pubertal.exposure.to. estrogenic. chemicals. affects. behavior. in. juvenile.and.adult.male.rats..50:301.–.307. 50.. Negishi.T,.Kawasaki.K,.Suzaki.S,.Maeda. H,.Ishii.Y,.Kyuwa.S,.Kuroda.Y,.Yoshikawa. Y.(2004).Environ Health Perspect..Behavioral.alterations.in.response.to.fear-provoking. stimuli. and. tranylcypromine. induced.by.perinatal.exposure.to.bisphenol. A. and. nonylphenol. in. male. rats.. 112:. 1159.–.1164. 51.. Ho.SM,.Tang.WY,.Belmonte.de.Frausto. J,.Prins.GS.(2006).Cancer Res..Developmental.exposure.to.estradiol.and.bisphenol.A.increases.susceptibility.to.prostate.carcinogenesis. and. epigenetically. regulates. phosphodiesterase. type. 4. variant. 4.. 66:. 5624.–.5632. 52.. Durando. M,. L.. K,. Piva. J,. Sonnenschein. C,.Soto.AM,.Luque.E,.Muñoz-de-Toro.M. (2007).Environ Health Perspect..Prenatal. bisphenol.A.exposure.induces.preneoplastic.lesions.in.the.mammary.gland.in.Wistar. rats..115:80.–.86. nTp brief
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National Toxicology Program U.S. De
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[This page inTenTionally lefT blank
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NTP.will.transmit.the.NTP-CERHR.<st
Page 10: National Toxicology Program U.S. De
Page 13 and 14: [This page inTenTionally lefT blank
Page 15 and 16: nTp brief tainers.with.internal.epo
Page 17 and 18: Population Adult General. Populatio
Page 19 and 20: Table 3. Blood and Breast Milk Biom
Page 21 and 22: Figure 2b. The weight of evidence t
Page 23 and 24: in.considering.the.biological.plaus
Page 25 and 26: isphenol.A.as.efficiently.as.adult.
Page 27 and 28: isphenol.A..For.example,.this.raise
Page 29 and 30: laboRaToRy aNImal STudIeS In.contra
Page 31 and 32: of.normal.sex-based.differences.bet
Page 33 and 34: death.(168),.synaptic.plasticity.(1
Page 35 and 36: gland.carcinogen.or.that.bisphenol.
Page 37 and 38: understand.the.possible.long-term.c
Page 39 and 40: strategies.to.improve.the.sensitivi
Page 41 and 42: • • Howdeshell.et.al. (55).repo
Page 43 and 44: and.cystic.endometrial.hyperplasia.
Page 45 and 46: cutaneous. injection. 20 . vom. Saa
Page 47 and 48: are CurrenT exposures To bisphenol
Page 49 and 50: w/day;.95th.percentiles.0.289.-.0.2
Page 51 and 52: nTp ConClusions The.NTP.reached.the
Page 53 and 54: appendix a: inTerpreTaTion of blood
Page 55 and 56: µg/kg.bw/day.based.on.the.assumpti
Page 57 and 58: concentrations.from.maternal,.fetal
Page 59: 12.. Padmanabhan. V,. Siefert. K,.
Page 63 and 64: 65.. Alonso-Magdalena. P,. Laribi.
Page 65 and 66: 91.. Calabrese.EJ,.Baldwin.LA.(2003
Page 67 and 68: Thyroid.Function.in.Juvenile.Female
Page 69 and 70: droxylase.immunoreactivity..76:423.
Page 71 and 72: stanceschimiques.gc.ca/challenge-de
Page 73 and 74: Watanabe.H,.Ohta.Y,.Iguchi.T.(2006)
Page 75 and 76: 226..vom. Saal. FS,. Cooke. PS,. Bu
Page 77 and 78: solid.phase.extraction-high.perform
Page 79 and 80: appendix i. nTp-Cerhr bisphenol a e
Page 81 and 82: 158 CHAPIN ET AL. the CERHR Core Co
Page 83 and 84: 160 CHAPIN ET AL. referred to as 4,
Page 85 and 86: 162 CHAPIN ET AL. concentrations in
Page 87 and 88: 164 CHAPIN ET AL. Food (no. sampled
Page 89 and 90: 166 CHAPIN ET AL. Table 6 Continued
Page 91 and 92: 168 CHAPIN ET AL. comparison of the
Page 93 and 94: 170 CHAPIN ET AL. Table 8 Urinary C
Page 95 and 96: 172 CHAPIN ET AL. the blood of male
Page 97 and 98: 174 CHAPIN ET AL. Table 11 Bispheno
Page 99 and 100: 176 CHAPIN ET AL. Table 13 Summarie
Page 101 and 102: 178 CHAPIN ET AL. Table 15 Estimate
Page 103 and 104: 180 CHAPIN ET AL. Table 17 Maximum
Page 105 and 106: 182 CHAPIN ET AL. 2.0 GENERAL TOXIC
Page 107 and 108: 184 CHAPIN ET AL. fetuses (3.572.7
Page 109 and 110: 186 CHAPIN ET AL. Secondary sources
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188 CHAPIN ET AL. Table 25 Maternal
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190 CHAPIN ET AL. Table 27 Bispheno
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192 CHAPIN ET AL. Table 31 Qualitat
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194 CHAPIN ET AL. Table 33 Toxicoki
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198 CHAPIN ET AL. appeared to occur
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200 CHAPIN ET AL. Table 43 Biliary
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202 CHAPIN ET AL. suggesting that 4
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204 CHAPIN ET AL. low following ora
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206 CHAPIN ET AL. scaling and speci
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208 CHAPIN ET AL. 60-100% in each d
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210 CHAPIN ET AL. related. No histo
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212 CHAPIN ET AL. Table 52 Continue
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214 CHAPIN ET AL. Model and exposur
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216 CHAPIN ET AL. Model and exposur
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218 Model and exposure Husbandry a
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220 CHAPIN ET AL. Table 54 Differen
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222 CHAPIN ET AL. Table 56 Anti-And
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224 Table 57 In Vitro Genetic Toxic
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226 CHAPIN ET AL. Table 58 In Vivo
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228 CHAPIN ET AL. Table 59 Developm
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232 CHAPIN ET AL. Table 64 Tissue R
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236 CHAPIN ET AL. treatment conditi
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238 CHAPIN ET AL. clinical signs, b
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240 CHAPIN ET AL. Table 71 Benchmar
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242 CHAPIN ET AL. group, 5 from 1 l
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244 CHAPIN ET AL. least significant
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246 CHAPIN ET AL. group was a reduc
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248 CHAPIN ET AL. 100-151 g for fem
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250 CHAPIN ET AL. 3.2.3.2 Developme
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252 CHAPIN ET AL. weights, bispheno
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254 CHAPIN ET AL. 120 mg/kg bw/day
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256 CHAPIN ET AL. comparisons condu
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258 CHAPIN ET AL. the findings of t
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260 CHAPIN ET AL. analyzed.] Anogen
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262 CHAPIN ET AL. purposeful confou
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264 CHAPIN ET AL. increased lordosi
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266 CHAPIN ET AL. that there was a
Page 191 and 192:
268 CHAPIN ET AL. duration of adver
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270 CHAPIN ET AL. doses of potent e
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272 CHAPIN ET AL. Table 74 Effects
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274 CHAPIN ET AL. reproductive orga
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276 CHAPIN ET AL. tyrosine-hydroxly
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278 CHAPIN ET AL. include small sam
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280 CHAPIN ET AL. males/group. [It
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282 CHAPIN ET AL. termination, whic
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284 CHAPIN ET AL. provided a reliab
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286 CHAPIN ET AL. grooming, and out
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288 CHAPIN ET AL. method of oral do
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290 CHAPIN ET AL. reared by their d
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292 CHAPIN ET AL. has been informed
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294 CHAPIN ET AL. buffered paraform
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296 CHAPIN ET AL. unit. Further, th
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298 CHAPIN ET AL. PND 21 and housed
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300 CHAPIN ET AL. Tando et al. (200
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302 CHAPIN ET AL. Purina Certified
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304 CHAPIN ET AL. high-doses of bis
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306 CHAPIN ET AL. born to those dam
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308 CHAPIN ET AL. average weight we
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310 CHAPIN ET AL. study authors con
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312 CHAPIN ET AL. used for extracti
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314 CHAPIN ET AL. jar, and there we
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316 CHAPIN ET AL. of testes and com
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318 CHAPIN ET AL. differentiation o
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320 CHAPIN ET AL. Table 81 Summary
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322 CHAPIN ET AL. Table 82 Continue
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328 CHAPIN ET AL. 600 mg/kg bw/day)
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330 CHAPIN ET AL. (Nagao et al., 19
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332 CHAPIN ET AL. antinuclear antib
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334 CHAPIN ET AL. least 6 animals.
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336 CHAPIN ET AL. Utility (Adequacy
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338 CHAPIN ET AL. stomach weight wa
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340 CHAPIN ET AL. Schirling et al.
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342 CHAPIN ET AL. Endpoint Table 88
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344 CHAPIN ET AL. different diets b
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346 CHAPIN ET AL. with 40 mg vitami
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348 CHAPIN ET AL. the bisphenol A v
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350 CHAPIN ET AL. and determining t
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352 CHAPIN ET AL. expression [to B6
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354 CHAPIN ET AL. indicated] at 0 (
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356 CHAPIN ET AL. concentrations us
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358 CHAPIN ET AL. animals were non-
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360 CHAPIN ET AL. following adjustm
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362 CHAPIN ET AL. Table 94 Treatmen
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364 CHAPIN ET AL. Table 97 Effects
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366 CHAPIN ET AL. Table 99 Treatmen
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368 CHAPIN ET AL. Therefore the NTP
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370 CHAPIN ET AL. weeks before mati
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Page 297 and 298:
374 Table 101 Summary of High Utili
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376 Table 102 Summary of Limited Ut
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Page 303 and 304:
380 CHAPIN ET AL. from other suppli
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382 CHAPIN ET AL. U.S. populations.
Page 307 and 308:
384 CHAPIN ET AL. 10. Critical desi
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386 CHAPIN ET AL. Engel SM, Levy B,
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388 CHAPIN ET AL. alpha and beta ex
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390 CHAPIN ET AL. Murray TJ, Maffin
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392 CHAPIN ET AL. Ryan BC, Vandenbe
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394 CHAPIN ET AL. Thomas P, Dong J.
Page 319 and 320:
Page 321:
appendix iii. publiC CommenTs and p
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