Monograph on the Potential Human Reproductive and ... - OEHHA

322 CHAPIN ET AL.
Table 82
Continued
Bisphenol A dose level (mg/kg bw/day) Reference
Model (treatment) Endpoint NOAEL LOAEL BMD 10 BMDL 10 BMD 1SD BMDL 1SD
anogenital distance
in males or females;
areolas/nipples in males
Mouse
CD-1 dam m Resorptions/litter 1000 1250 817 377 1245 1162 Morrissey
(gavage GD 6–15) et al. (1987)
k Fetal body weight/litter 1000 1250 1079 785 1249 1024
C57BL/6N males Sperm density or lesions Z0.200 Nagao et al.
(gavage GD 11–17
or PND 21–43)
in reproductive organs (high dose) (2002)
k Absolute seminal r0.002
vesicle weight in (low dose) a,b
group exposed
during gestation
CF-1 (oral by pipette, m Prostate weight r0.002 Nagel et al.
GD 11–17) (low dose) (1997)
C57BL/6 dam (gavage no effect AGD or Z0.2 Ryan and
GD 3–PND 21) AGD corrected (high dose) Vandenbergh
for body weight (2006)
No effect on errors in Z0.2
radial arm and
Barnes mazes
(high dose)
k Time in open arms
of plus maze
0.002 0.2
k Time in light part
of light/dark
preference box
0.002 0.2
CD-1 (dietary, multiple k F1 body weight 50 600 548–560 267–313 580–617 370–506 Tyl et al. (2006)
generations with
exposure during
pre- and post-natal
development)
on PND 7, 14, and 21
kF1 male body weight
at PND 21 necropsy
50 600 564 313 640 599
kF1 female body weight
at PND 21 necropsy
50 600 387 254 776 598
Hepatic cytoplasmic
variation, F1 male
5 50 124 92.5
Hepatic cytoplasmic
variation, F2 male
50 600 224 178
Hepatic cytoplasmic
variation, F1 female
5 50 333 200
Seminiferous tubule
hypoplasia, F1 male
50 600 591 406
Seminiferous tubule
hypoplasia, F2 male
5 50 283 233
Age of preputial separation,
F1 parental or
non-mated males
50 600 727–754 572–576 491–551 364–414
Anogenital distance
per body weight,
F1 male on PND 21
5 50 1373 607 1769 616
Postnatal survival; daily Z600
sperm production; efficiency
of daily sperm production;
sperm motility or
morphology;
estrous cyclicity;
numbers of
ovarian primordial follicles;
mating or fertility indices;
or adult prostate weight
(high dose)
a There was little to no evidence of a dose-response relationship.
b No effects were observed at one or more higher dose levels.
Birth Defects Research (Part B) 83:157–395, 2008