Monograph on the Potential Human Reproductive and ... - OEHHA

218
Model and exposure Husbandry a
CHAPIN ET AL.
Table 53
Continued
Endpoint Molar potency/comparator b
Reference
Immature AP, s.c. x 3 RM1 diet, plastic Blotted uterine weight [2.3 x 10 -5 ]/diethylstilbestrol in 4 of 8 Tinwell and
days cage, sawdust trials; other trials showed no effect Joiner (2000)
and shredded at bisphenol doses up to 300 mg/kg
paper bedding bw/day
Immature AP, RM1 diet, plastic Blotted uterine weight No effect at bisphenol A doses up to Tinwell and
gavage x 3 days cage, sawdust 300 mg/kg bw/day; Joiner (2000)
and shredded diethylstilbestrol produced
paper bedding response at 10 mg/kg bw/day
Immature CD-1, RM1 diet Lactoferrin expression No effect at bisphenol A doses up to Mehmood et al.
s.c. x 3 days 1000 mg/kg bw/day; (2000)
diethylstilbestrol showed effect at
0.1 mg/kg bw/day
Uterine weight, BrdU No effect at bisphenol A doses up to
incorporation, 100 mg/kg bw/day;
peroxidase production diethylstilbestrol showed effect at
1–5 mg/kg bw/day
Immature CD-1, s.c. RMH 3000 diet, Uterine wet weight [1.6 x 10 -5 ]/17b-estradiol Markey et al.
minipump x 3 days cage, and (2001b)
bedding
estrogennegative
by E-
Screen
Epithelial cell height [3.8 x 10 -5 ]/17b-estradiol
Lactoferrin expression [3.9 x 10 -5 ]/17b-estradiol
Ovariectomized adult Not indicated Relative uterine to body [3.6–74 x 10 -5 ]/17b-estradiol Kitamura et al.
B6C3F1, i.p. x 3 days weight (2005)
Ovariectomized adult Economy Increased uterine B1 x10 -4 /17b-estradiol Milligan et al.
Swiss, s.c. x 1 Rodent vascular permeability (1998)
Maintenance
diet
Other mouse organs
Juvenile-adult NMF diet Uterine and ovarian Dietary bisphenol A (0.1%) exerted Toda et al. (2002)
aromatase knock-out, histology, bone mineral estrogenic effects. Mean7SD serum
diet x 4 months density bisphenol A 84.378.7 mg/L. No
comparator estrogen was used for
these endpoints
Fish
Immature rainbow Plasma vitellogenin [3 x 10 -4 ]/17b-estradiol Christiansen
trout, injected et al. (1997)
Juvenile rainbow trout, Plasma vitellogenin [5.6 x 10 -3 ]/17b-estradiol Andersen et al.
injected (1999a)
Juvenile rainbow trout, Plasma vitellogenin [B8.4 x 10 -5 ]/17b-estradiol Lindholst et al.
exposed in water (2000)
Male medaka, exposed Plasma vitellogenin [1.4 x 10 -4 ]/ethinyl estradiol Chikae et al.
in feed (2003)
Male medaka, exposed Hepatic vitellogenin and [8.4 x 10 -6 ]/17b-estradiol Yamaguchi et al.
in water ERa mRNA (2005)
Male killfish, injected Plasma vitellogenin [2.7 x 10 -4 ]/17b-estradiol Pait and Nelson
(2003)
Male zebrafish, Plasma vitellogenin [B0.2]/ethinyl estradiol Van den Belt
juvenile rainbow trout, et al.(2003)
exposed in water
Invertebrates
Mud snail, exposed in New embryo production [1.5 x 10 -4 ]/ethinyl estradiol Jobling et al.
water (2004)
Ramshorn snail, Egg production Increased (EC 10 13.9 ng/L); blocked by Oehlmann et al.
exposed in water Faslodex and tamoxifen. No (2006)
comparison to reference estrogen
a Husbandry information for rodent studies includes caging and bedding materials and diet when indicated by the authors.
b Estimates include comparison of administered dose, magnitude of effect, and molecular weight.
represents fluid inbibition and not true tissue growth. A 42/43 with bisphenol A by gavage at 400 or 600 mg/kg
dose-related decrease in blotted uterine weight and body bw/day (George et al., 2003).
weight, with no effect on weight-adjusted uterine For studies showing an increase in uterine weight after
weight, was shown in pubertal rats treated on PND 22– bisphenol A treatment, dose route affects response;
Birth Defects Research (Part B) 83:157–395, 2008