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Richtlijn Niercelcarcinoom

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Conclusie PA rapport<br />

In de conclusie moeten tenminste de volgende items vermeld worden:<br />

1) Diameter tumor (NB stadiëringsgrenzen liggen bij 4 cm en 7 cm)<br />

2) Histologisch type volgens WHO 2002<br />

3) Fuhrman graad<br />

4) Eventuele secundaire veranderingen die van belang zijn voor prognose en adjuvante<br />

therapie, zoals sarcomatoïde component. Uitgebreidheid necrose en microvaatinvasie<br />

zijn vooralsnog optioneel<br />

5) Bloedvatinvasie in renale vene of intrahilaire segmentale vertakkingen daarvan<br />

6) Extrarenale uitbreiding (kapseldoorgroei, ingroei peripelvaire renale sinus vetweefsel,<br />

bijnieren, fascia van Gerota, eventueel aangrenzende organen)<br />

7) Status resectieranden<br />

8) Regionale lymfklieren<br />

9) Voorstel pathologie stadium volgens TNM 2002 of recentere versie<br />

Literatuur<br />

Amin MB, Amin MB, Tamboli P, Javidan J, Stricker H, Peralta-Venturina M, et al. Prognostic<br />

impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405<br />

cases. Am.J.Surg.Pathol. 2002; 26[3], 281-291<br />

Brinker DA, Amin MB, Peralta-Venturina M, Reuter V, Chan DY, Epstein JI. Extensively<br />

necrotic cystic renal cell carcinoma: a clinicopathologic study with comparison to other cystic<br />

and necrotic renal cancers. Am.J.Surg.Pathol. 2000; 24[7], 988-995<br />

Blute 2004, Leibovich BC, Cheville JC, Lohse, Zincke H, A protocol for performing extended<br />

lymph node dissection using primary tumor pathological features for patients treated with<br />

radical nephrectomy for clear cell renal cell carcinoma J. Urol 2004, 172(2):465-469<br />

Cheville JC, Lohse CM, Zincke H, Weaver AL, Blute ML. Comparisons of outcome and<br />

prognostic features among histologic subtypes of renal cell carcinoma. Am.J.Surg.Pathol.<br />

2003; 27[5], 612-624<br />

Cheville J.C. Lohse CM, Zincke H, Wezver AL, Leibovich BC, Frank I, Blute ML, Sarcomatoid<br />

renal cell carcinoma: an examination of underlying histologic subtype and an analysis of<br />

associations with patient outcome. Am J Surg Pathol. 2004 Apr;28(4):435-41<br />

Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, Zincke H. An outcome prediction<br />

model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based<br />

on tumor stage, size, grade and necrosis: the SSIGN score. J.Urol. 2002; 168[6], 2395-2400<br />

Goncalves PD, Srougi M, Dall’lio MF, Leite KR, Ortiz V, Herig F, Low clinical stage renal cell<br />

carcinoma: relevance of microvascular tumor invasion as a prognostic parameter. J Urol.<br />

2004 Aug;172(2):470-4<br />

Ishimura T, Sakai I, Hara I, Etot H, Miyake H, Microscopic venous invasion in renal cell<br />

carcinoma as a predictor of recurrence after radical surgery. Int J Urol. 2004 May;11(5):264-<br />

Moch H, Gasser T, Amin MB, Torhorst J, Sauter G, Mihatsch MJ. Prognostic utility of the<br />

recently recommended histologic classification and revised TNM staging system of renal cell<br />

carcinoma: a Swiss experience with 588 tumors. Cancer 2000; 89[3], 604-614<br />

Mrstik C, Salamon J, Weber R, Stogermayer F, Microscopic venous infiltration as predictor of<br />

relapse in renal cell carcinoma. J Urol. 1992 Aug;148(2 Pt 1):271-4<br />

Van Poppel, VandendriesscheH, Boel K, Mertens V, Goethuys H, Haustermans K, Van<br />

Damme B, Baert L. Microscopic vascular invasion is the most relevant prognosticator after<br />

radical nephrectomy for clinically nonmetastatic renal cell carcinoma. J Urol 1997;158:45-49<br />

47

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