ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

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Table 21. Effect of co-administration of TCDD and vitamin E on the serum hormone lcvels in adult male rats -- TCDD and vitamin E Control 1ngs20mg 10ng+20mg 100ng+20mg Testosterone' 2.51 i 0.13 2.48 f 0.08 2.35 f 0.05 2.34 _+ 0.06 FSH' 15.66f 2.08 14.00k 0.40 15.25 i 1.84 14.63 r 0.30 Prolactin' 18.33 f 1.52 17.50i 0.57 18.25 i 1.25 19.75 zt 1.21 'ngl mL; bpg/ mL The data are expressed as mean SD for six animals/ dose Table 22. Effect of co-administration of TCDD and vitamin E on the activities of stemidogenic enzymes in testis. TCDD and vitamin E Cotitrol Ing+20mg lOng+201ng 100ng+20mg 3-P hydroxysreroid 54.31 2 2.68 56.14 k 3.96 55.63 f 3.01 53.44 + 3.46 dehydrogenax The data arc expressed in nmolel mild mg protein The data are expressed and rneaniSD for six animalsi dose
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FUNCTIONAL STUDIES ON THE EFFECTS O
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ACKNOWLEDGEMENTS I wish to express
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TABLE OF CONTENTS Page No ACKNOWLED
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TABLE OF CONTENTS (Continued) Deter
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TABLE OF CONTENTS (Continued) Effec
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TAULIC OF CON'I'ISN'I'S (C'untinued
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xi LIST OF TABLES (Continued) I'agc
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Table 24a Table 24b Table 24c Table
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Fig. 1 Fig. 2 Effect of TCDD on the
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Fig. 12c Fig. 12d Fig. 13 Fig. 14a
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LIST OF FIGURES (Continued) Fig. 23
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LH M PL mg mRNA N AD NADH NADP NADP
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layers, an outer layer of visceral
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tubular epithelium and continually
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lmn~unization of monkeys against FS
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and this reaction is catalyzed by t
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extratubular environment or synthes
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the most active in protein secretio
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1958). A rapid fall in serum testos
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have also been reported in the rats
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Effect of TCDD on heart muscle has
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1.4 Effect of oxidative stress on m
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2 SCOPE OF THE PRESENT STUDY There
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3 MATERIALS AND METHODS 3.1 Animals
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Subgroup III: Administration of TCD
Page 51 and 52: choppcd with the help of sharp razo
Page 53 and 54: anti-FSH antibody. After incubation
Page 55 and 56: lust sped (500 to 700 rpm) on an or
Page 57 and 58: 3.13.4 Quantitative determinntiun u
Page 59 and 60: The plates were dried by inverting
Page 61 and 62: centrifuged at 3,500 g for I5 min o
Page 63 and 64: 3.17 Preparation of tiasue humogena
Page 65 and 66: supcrnutant was taken. Hlunk was pr
Page 67 and 68: 3.21.4 Assay of glutathione peroxid
Page 69: 4 RESULTS 4.1 Administration of TCD
Page 72 and 73: seminiferous tubules was found to b
Page 74 and 75: fractions of rat testis as compared
Page 76 and 77: 4.1.11.1 Effect of TCDD on the prod
Page 78 and 79: 4.2 Co-administration of TCDD and v
Page 80 and 81: 4.2.8 Effect of co-administration o
Page 82 and 83: 4.2.11.5 Effect of co-administratio
Page 84 and 85: Table I b. Effect of TCDD on the we
Page 86 and 87: Table 4. Effect of TCDD on the seru
Page 88 and 89: Table 7b. Effect of TCDD on the pro
Page 90 and 91: Table 8c. Effect of TCDD on the lev
Page 92 and 93: Table 9d. Effect of TCDD on the act
Page 94 and 95: Table 13. Effect of TCDD on the ant
Page 96 and 97: Table 15. Effect of TCDD on the lev
Page 98 and 99: Table 16c. Effcct of TCDD on the an
Page 100 and 101: Table 18a. Effect of co-administrat
Page 104 and 105: Table 23. Effect of co-administrati
Page 108 and 109: Table 26b. Effect of co-administrat
Page 110 and 111: 'I'able 28. Eff'ecl ol' co-admi~lis
Page 112 and 113: Table 31. Effect of TCDD on the pro
Page 116 and 117: Table 34b. Effect of co-administrat
Page 118 and 119: animals (Fig. 2) thereby causing sy
Page 120 and 121: of testosterone, estradiol, FSH, LH
Page 122 and 123: eduction in Leydig cell volume per
Page 124 and 125: een reported that TCDD decreases vo
Page 126 and 127: as compared to the corresponding gr
Page 128 and 129: (Latchuumycandane el ul.. 2002 b).
Page 130 and 131: sex organs against TCDD. Weight of
Page 132 and 133: to Fig. 15b; Table 29 and Fig. 19a
Page 135 and 136: Fig.4a. Effect of TCDD or TCDD and
Page 137 and 138: Fig.4~. Effect of TCDD or TCDD and
Page 141 and 142: Fig. 'la. Effect of TCDD or TCDD an
Page 143: Fig. 7c. ElTect of TCDD or TCDD and
Page 146 and 147: Fig.lOa. EBut of TCDD or TCDD and v
Page 148: Filk Effect of TCDD or TCDD and vit
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Fig. 14a. Effect of TCDD or TCDD an
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Fig. 1Sb. Effect of TCDD or TCDD an
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Fig.16d. Effect of TCDD or TCDD and
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Fig. 19a. Effect of TCDD or TCDD an
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60 Fig. 20a. Effect of TCDD or TCDD
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Fig. 2k. Ekt of TCDD or TCDD and vi
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Fig. 22a. EKect of TCDD or TCDD and
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Fig. 23b. Effect of TCDD or TCDD an
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Fig. 24d. Effect of TCDD or TCDD an
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Burkhart ER. A study of the early e
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de Kretaer DM. In: The Testis. Burg
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Griawold MD. Protein secretion by S
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June NHPM, Jansen R, Grootegoed JA,
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Mathur PP, Mo MY, Panzironi C, Silv
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Petenon RE, Scefeld MD, Christian W
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Shan LX. Hardy MP. Developmental ch
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Tindall DJ, MiUer DA, Means AR. Cha
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1.3.4 Antibody-Enzyme Conjugate sol
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1.6.2 Testosterone standards One vi
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22.91 pg of 4-androstcne 3,17-dione
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1.13 Subcellulnr frnctionation of t
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1.17.4 Disodium hydrogen phosphate
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1.22.2 NADPH (0.2 pM) 16.6672 mg of
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APPENDIX 2 LIST OF PUBLICATIONS OF
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~lLllc mu ~LYIC~L~ II*: ~[IL'IIII W
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Effect of lindane on testicular ant
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ILXlll hnl, .I 121; 1.0 -/.a . Ill
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Effect of lindane on antioxidant en
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WnCr, inyminn~nt of spmri motility,
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The effect of 2,3,7,8-tetrachlorodi
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I kl
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C'. I~~I~~~~IIIII~~O~,~~~~~~ R6+ 4,
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'lstrr,tb~xr 171 i?lYJ?I 127 /.IS I
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S.tlc. S.. ?IXII. Mubuli~r bioluyy
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(I't,l:~t~cl 211x1 Kin~hronglt IVX4
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t11.3. Wal 01 TCDD on !he acttnly o
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IIR h r k a ~ r Ilw ~ ;njllmr~ l ~
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C L m r ~ n . l l ~ T a d ~ 1 6 W J
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c urbmwen&n= s a( I n.pradpradpradn
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- aaarslu30 ,.*mra. L~jl;lr; -P4-w~
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(=I 23. w- C Olln (LC W W. Ubrth d-
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continuous exposure of humans to in
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pH 7.6). I00 pl of 200 mM NADPH, IW
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ioavaiiability andlor production of
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Glutnchlone irrox$dssc, rupcioridc
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ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

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