ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

Table 7b. Effect of TCDD on the production of nitric oxide in the crude ho~noyenute,
mitochondrial and microsome-rich fractions of' rat testis
TCDDl Kg body weight
Control I ng 10 ng I00 ng
Crude homogenate 2.38 f 0.10 3.61 * 0.08* 3.72 rt 0.04' 4.77 f 0.06.
Mitochondrial fractions 1.43 f 0.1 1 2.33 f 0.108 2.79 f 0.14' 3.10 1 0.42'
Microsome-rich
fractions 2.41 f 0.77 2.81 1 0.20* 3.01 10.14' 3.16* 0.72*
The values are expressed in mmole/ min/ mg protein
The data are expressed as mean i SD for six animals1 dose
'pcO.05 against the control
Table 7c. Effect of TCDD on the hydrogen peroxide generation in crude Iiomogenate,
mitochondrial and microsome-rich fractions of rat testis
TCDDI Kg body weight
Control I ng 10 ng I00 ng
Crudc Iromoyenatc 18.70 f 2.78 22.16 r 1.26. 74.1 7 + 2.88' 76.4 1 i 1 .St)*
Mitochondrial fractions 15.73 i 2.12 18.08 f 1.21' 19.87 i 1.14' 21.76 r 1.93'
Microsome-rich
fractions 12.68 f 2.01 16.31 22.41' 17.37 f 1.98. 19.45 i 1.89*
The values are expressed in nmold minl mg protein
The data are expressed as mean * SD for six animals1 dose
*p