ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

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de Kretaer DM. In: The Testis. Burgan HG, de Kretser DM (eds.). New York: Raven Prrss; 1982 76-90. de Kretser DM, Catt KJ, Paulsen CA. Studies on the in vilro testicular binding of iodinated luteinizing hormone in rats. Endocrinology 1971; 88: 332-337. de Kretaer DM, Loveland KL, Meinhardt A, Simorangkir D, Wreford N. Spermatogenesis. Human Rcprod 1998; 13: 1-8. de Kretacr DM, Meehan T. O'Bryan C, Wreford NG, McLachhn RI, Lovehnd KL. Replatory mechanisms in mammalian spermatogenesis. Testes, Epididyms and Technologies in the year 2000. In: Jegou B, Pineau C, Saez J (cds.). Berlin, Springer Verlag; 2000: 87-106. de Kretser DM, Risbridger GP, Kerr JB. Basic Endocrinology of the testis. In: Dcgroot LJ, Saunden WB (eds.). Endocrinology. Company, USA, 1995; 3: 2307- 2335. de Ruiter AJH. Testosterone dependent changes in vivo and in viho in the structure of the renal glomeruli of the teleost Gasrerosteus aculearus L. Cell Tissue Res 198 1 ; 2 19: 253-266. di Zerega GS, Sherim RJ. Endocrine control of adult testicular function. In: Burger H, de Krctser DM (eds.). The testis. New York: Raven Press; 1980: 127-1 40. Dufau ML, Hormer KA, Hayashi K, Tsuruhara T, Conn PM, Catt KR. Actions of choleragen and gonadotrophin in isolated Leydig cells. J Biol Chem 1978; 253: 3721. Dym M. The mammalian rete testis a morphological examination Anat Rec 1976; 186: 493-524. Eik-Nes KB. Biosynthesis and secretion of testicular steroids. In: Hamilton DW, Greep RO (eds.). Handbook of Physiology. Endocrinolgy: Male Reproductive System. Washington, D.C: American Physiology Society; 1975: 95-1 15. Ewing LL, Wing TY, Cochrnn RC, Kroman N, Zirkin BR Effect of luteinizing hormone on Leydig cell structure and testosterone secretion. Endocrinology 1983; 112: 1763-1769. Faqi AS, Dalsentcr PQ Ligensa A, Merker HJ, Chahoud I. Effect on male fertility and testis concentrations of low dose of 2,3,7,8-tetrachlorodibcllzo-p-dioxin (TCDD) in offspring of rats exposed during pregnancy and lactation. Teratology 1997; 56: 403. Fawcen DW. Ultrastructure and function of the Sertoli cells. In: Hamilton DW, Orrep RO (eds.). Handbook of Physiology. Endocrinology: Male Reproductive System. Washington, D.C: American Physiological Society; 1975: Vol. 5. pp.21- 25. Fawcett DW, Ncaves WB, Flom MN. Comparative observations on intertubular lym hatics and the organization of the interstitial tissue of the mammalian testis. Bior~eprod 1973; 9: 500-5 12. Fisher JD. Adrmoconicotrophin. In: Dorfman RI (eds.). Methods in hormone research: Bioassay. New York: Academic Press; 1962.
Flsher JS, Turner KJ, Brown D, Sharpe RM. Effect of neonatal exposure to estrogenic compounds on development of the excurrent ducts of the rat testis through puberty to adulthood. Environ Health Perspect 1999; 107: 397-405. Foucault P, Carrenu S, ,Kuaynski W, Guillaumin JM, Bardos P, Drosdowsky MA. Human Sat011 cells in virro: Lactate, estradiol-17P and transferrin production. J Androl 1992; 13: 361 -367. Fritz KB, Rommerta FG, Louis BG, Dorrington JH. Regulation by FSH and dibutyryl cyclic AMP of the formation of androgen-binding protein in Sertoli cell-enriched cultures. I Reprod Fertil 1976; 46: 17-24. Funder JW. Paracrine, Cryptocrine , acrocrine. Mol Cell Endocrinol 1990; 70: C21- C24. Garg MC, Bansnl DD. Protective antioxidant effect of vitamin C and E in streptowtocin induced diabetic rats. Indian J Exp Biol 2000; 38: 101-104. Ghosh PK, Biswass NM, Ghosh D. Effect of lithium chloride on spermatogenesis and testicular steroidogenesis in mature albino rats: duration dependent response. Life Sci 1991; 48: 649-657. Ghosh PK, Ghosh D, Ghosh P, Chaudhuri A. Effects of prostatectomy on testicular androgenesis and serum levels of gonadotrophins in mature albino rats. Prostate 1995; 26: 19-22. Gray LE Jr, Ostby JS, Kelce WR Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rats. Toxicol Appl Pharmacol 1994; 129: 46-52. Gray LE Jr, Ostby JS, Kelce WR A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8-tetrachlorodibenzo-pdioxin in male Long Evans Hooded rat offspring. Toxicol Appl Pharmacol 1997; 146: 1 1-20, Gray LE Jr. Ostby J, Ferrell J, Sigmon R, Cooper I
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FUNCTIONAL STUDIES ON THE EFFECTS O
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ACKNOWLEDGEMENTS I wish to express
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TABLE OF CONTENTS Page No ACKNOWLED
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TABLE OF CONTENTS (Continued) Deter
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TABLE OF CONTENTS (Continued) Effec
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TAULIC OF CON'I'ISN'I'S (C'untinued
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xi LIST OF TABLES (Continued) I'agc
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Table 24a Table 24b Table 24c Table
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Fig. 1 Fig. 2 Effect of TCDD on the
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Fig. 12c Fig. 12d Fig. 13 Fig. 14a
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LIST OF FIGURES (Continued) Fig. 23
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LH M PL mg mRNA N AD NADH NADP NADP
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layers, an outer layer of visceral
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tubular epithelium and continually
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lmn~unization of monkeys against FS
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and this reaction is catalyzed by t
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extratubular environment or synthes
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the most active in protein secretio
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1958). A rapid fall in serum testos
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have also been reported in the rats
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Effect of TCDD on heart muscle has
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1.4 Effect of oxidative stress on m
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2 SCOPE OF THE PRESENT STUDY There
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3 MATERIALS AND METHODS 3.1 Animals
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Subgroup III: Administration of TCD
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choppcd with the help of sharp razo
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anti-FSH antibody. After incubation
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lust sped (500 to 700 rpm) on an or
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3.13.4 Quantitative determinntiun u
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The plates were dried by inverting
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centrifuged at 3,500 g for I5 min o
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3.17 Preparation of tiasue humogena
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supcrnutant was taken. Hlunk was pr
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3.21.4 Assay of glutathione peroxid
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4 RESULTS 4.1 Administration of TCD
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seminiferous tubules was found to b
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fractions of rat testis as compared
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4.1.11.1 Effect of TCDD on the prod
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4.2 Co-administration of TCDD and v
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4.2.8 Effect of co-administration o
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4.2.11.5 Effect of co-administratio
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Table I b. Effect of TCDD on the we
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Table 4. Effect of TCDD on the seru
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Table 7b. Effect of TCDD on the pro
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Table 8c. Effect of TCDD on the lev
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Table 9d. Effect of TCDD on the act
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Table 13. Effect of TCDD on the ant
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Table 15. Effect of TCDD on the lev
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Table 16c. Effcct of TCDD on the an
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Table 18a. Effect of co-administrat
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Table 21. Effect of co-administrati
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Table 24b. Effect of co-administrat
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Table 25c. Effect of co-administrat
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Table 26d. Effect of co-administrat
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Table 30. Effect of co-administrati
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Table 32. Effect of caadrninistrati
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Table 33c. Effcct of co-administrut
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5 DISCUSSION 5.1 Significance of th
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Measurement of weights of the acces
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compartment of the cells (Chainy el
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the reduction in daily sperm produc
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eported in the TCDD-treated rats (M
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lilnction is to ililcrccpt lipid pc
Page 129 and 130: in the animals administered with TC
Page 131 and 132: protective effects on serum testost
Page 133: suygcstccl that vivamin 1: conld im
Page 136 and 137: Fig.4~. ENect of TCDD or TCDD and v
Page 138: tE W d In w it I I (,OCX) 3s PUB (,
Page 142 and 143: Fig. 7c. Effect of TCDD or TCDD and
Page 145 and 146: u 3 f ~ = m w * N O .- ~Slew aew en
Page 147 and 148: Fig.lOb. ENmt of TCDD or TCDD and v
Page 151: Fig. 1Ir Effect of TCDD or TCDD md
Page 158 and 159: Fig. 14c. Effect of TCDD or TCDD an
Page 160 and 161: Fig. 16b. Effect of TCDD or TCDD an
Page 164 and 165: Fig.18~. EKect of TCDD or TCDD and
Page 166 and 167: 1 1.2 l4 Fig. 19b. ENect of TCDD or
Page 168 and 169: Fig. ZOb. Elkt of TCDD or TCDD and
Page 171 and 172: Fig. 21. Effect olTCDD or TCDD and
Page 173 and 174: Fig. 22c. Effect of TCDD or TCDD an
Page 175 and 176: Fig. 24b. Eflect ofTCDD or TCDD and
Page 177 and 178: 7 REFERENCES Aitken RJ, Irvine DS,
Page 179: Chitm KC, Latchoumycandanc,C, Mathu
Page 183 and 184: Hornsby PJ. Regulation of cytochrom
Page 185 and 186: Latcboumycandane C, Chitra KC, Math
Page 187 and 188: Moore RW, Panona JA, Bookstaff RC,
Page 189 and 190: Rommerts FFG, Cooke BA, Van Der Kem
Page 191 and 192: Slaunwhite WR, Burgett MJ. h virro
Page 193 and 194: 1.1 Preparation of dosing solution
Page 195 and 196: 1.4.6 Wash concentrate One bottle,
Page 197 and 198: 1.7.3 Estradiol controls Two vials.
Page 199 and 200: 1.1 1.2 Orcinol(6%) 6 g of orcinol
Page 201 and 202: 1.16.2 Horseradish peroxidase (8 Un
Page 203 and 204: 1.20 Superoxide dismutase 1.20.1 Tr
Page 205 and 206: 1.24.2 Thiobarbituric acid (TBA; 0.
Page 207 and 208: Chronic effect: of enclosulfan on t
Page 209: enbw1h1.W mu IUY Wcab unpiliml~t at
Page 212 and 213: cbniuis 11~11 b"nci:~lc ~wlive oxyg
Page 214 and 215: DNA, RNA ;uxl Wcin wcrr abarval, wh
Page 216 and 217: Mt~~m(10-lZsu&)vacob- Wfmn Ihehml ~
Page 218 and 219: New Delhi, llrliil Ib SCI~KK Rcm& M
Page 220 and 221: tiii~lc rcprmluction or rut (Cllitr
Page 222 and 223: wciglit (b.wt.) per day for 45 days
Page 224 and 225: 0.1 00 01 " 0.8 I . .lo Dl* rcnn IW
Page 226 and 227: Chilr:~. K.C.. L!olnn!myci!~dum. C.
Page 228 and 229: C. hteboumyeradlos . KC. CMtn . P.P
Page 230 and 231:
I. 1 Ilal 01 2 1.7 # I c I ~ ~ L I
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Fin. L Corrclatwn bclwfcn "perm cou
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Iionshii nepmdvctivc mxicity ad upt
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o. Glutathione reductage mg pmWn mg
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IOWAME -. Tor. #558517 PME: 9 SESS:
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JOBNAME: Rqm. Tm. M5W7 PAOB: 11 SBS
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t 02 ELSEVIER Toricology OM) (2W1)
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---- - wcre obtu~ncd from E-Monk. G
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3.2. A,III~AILNI syrlo~t of ,nIroch
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Uc,#!dy. SC. N;tdcru. S , 1% Conlrb
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