ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

JOBNAME: Rqm. Tm. M5W7 PAOB: 11 SBS: 5 OUmJT Tuc an 29 IO:W:~I zm2
MsbZla-m+m,iwasw-m
cpididyrnis against lipid peraxidation mduced by me.
thoxychlor by inCreasing antioxidant enzymes md de.
crcains ROS geamtion. 1n addition, tosopbcml sup-
PrcsEM lhe prcducdon of reactive oxidants and pmly
impmvcl s pm motility (401. It has bsaa repartcd that
vitamin E raises superoxide dismutasc activity in bovine
sprm [411.
Out results suggcst that exposure to melhoxychlor
induces depletion in antioxidant defenrc system in the
cpldidyrnie and opididymal sperm indisarlng methorychlor-induced
oxidative smss in the epidrdymia. Thtr
effect may lead to disruption in the functional integrity of
cell orgmcller. We present study also suggests thal coadnunisvation
of vitamin E with methorychlor prevents
the advcne cffecfa of methorychlor on antioxidant status
8s well ar improving sperm motility in adult rats. In
conflvrion the adverse effect of mcthorychior on male
reproduction of rats may be due to the induction of
oxidative rmrr. These effects could be nilevistcd by the
antioxidant viumin E.
IM authors aclmowledgc Dr. Ufe Tiem. Germany for
lhe gifl of mcthoxychlor md the sfaff of the Bioinformat>ci
Ccnlr. Pondichcny University for various foeilltier. C. L.
thank8 lo thc Indian Council of Medical Rwrch. Ncw
Delhi for Senior Research Fcilowrtup and P.P.M, acknawledger
the Populntlon Council. New Yark for finunclul it*.
r,stunce (Gnni Nu~.DY~.~U~P-Y~CMC and II1)P,lUYI