ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

4.2.8 Effect of co-administration of TCDD and vitamin E on the production of
reactive oxygen species in the crude homogenate, mitochondrial and
microsome-rich fractiom of testis
Co-administration of TCDD and vitamin E did not show any significant
change in the production of superoxide anion, nitric oxide and hydrogen peroxide in
crude testicular homogenate as well as in mitochondrial and microsome-rich fractions
of rat testis as compared to the corresponding groups of control animals (Table 24a;
24b & 24~).
4.2.9 Effect of co-administration of TCDD and vitamin E on the levels of
antioxidant in the crude homogenate, mitochondrial and microsome-rich
fractions of testis
Co-administration of TCDD and vitamin E did not show any significant
change in the levels of reduced glutathione, a-tocopherol and ascorbic acid in the
crude testicular homogenate as well as in mitochondrial and niicrosome-rich fractions
of rat testis as compared to the corresponding groups ot' control animals (Table 25a;
25b & 25c).
4.2.10 Effect of co-administration of TCDD and vitamin E on the antioxidant
enzymes and lipid peroxidation in crude homogenate, mitochondrial and
microsome-rich fractions of testis
Co-administration of TCDD and vitamin E did not show any significant
change in the activities of superoxide dismutase, catalase, glutathione reductase and
glutathione peroxidase as well as the levels of lipid peroxidation in the crude
t~sticular homoycnatc. mitochondrial and microso~nc-riel1 lii~ctil~ns 01' r;11 tcsti?, as
comparcd to the corresponding groups vl'contrul animals ('lhblc 26a (o 20d LY: 27).
4.2.11 Effect of co-administration of TCDD and vitamin E on epididymal sperm
Rats were treated with TCDD and vitamin E in order to see the effect of co-
administration on the epididymal sperm of adult rats.