ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

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APPENDIX 2 LIST OF PUBLICATIONS OF THE CANDIDATE During the course of the study the candidate has published following papers and the available reprints/ preprints are being enclosed. 1 K.C. Chitra, C. Latchoumycandane and P.P. Mathur (1999). Effect of endosulfan on the testicular functions of rat. Asian Journal of Andrology 1: 203- 206. 2 R. Sujatha, K.C. Chitra C. Latchoumycandane and P.P. Mathur (2001). Effect of lindane on the testicular antioxidant system and steroidogenic enzymes in adult rats. Asian Journal of Andrology. 3: 135-1 38. 3 K.C. Chitra, R. Sujatha., C. Latchoumycandane and P.P. Mathur (2001). Effect of lindane on the epididymal antioxidant enzymes in adult rats. Asian Journal of Andrology. 3: 205-208. 4 C. Latchoumycandane, K.C. Chitra and P.P. Mathur (2002). The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antioxidant system of rat testis mitochondrial and microsomal fraction. Toxicology, 171 : 127-35. 5 C. Latchoumycandane, K.C. Chitra and P.P. Mathur (2002). Induction of oxidative stress on the epididymal sperm of rats after exposure to 2,3,7,8- tetrachlorodibenzo-dioxin. Archives of Toxicology, 76: 1 13-1 18. 6 C. Latchoumycandane, K.C. Chitra and P.P. Mathur (2002). The effect of methoxychlor on the epididymal antioxidant system of adult male rats. Reproductive Toxicology, 16: 16 1-1 72. 7 C. Latchoumycandane, and P.P. Mathur (2002). Effect of methoxychlor on the antioxidant system of mitochondrial and microsome-rich fractions of rat testis. Toxicology, in press. 8 C. Latchoumycandane, and P.P. Mathur (2002). lnduction of oxidative stress in testis of rat after short-term exposure to organochlorine pesticide methoxychlor. Archives of Toxicology, in press. 9 K.C. Chitra, C. Latchoumycandane. P.P. Mathur (2002). Effect of nonylphenol on the antioxidant system in epididymal sperm of rats. Archives of Toxicologv, in press. 10 C. Latchoumycandane, and P.P. Mathur (2002). Effects of vitamin E on reactive oxygen species mediated 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in rat testis. Journal of Applied Toxicology, in press.
Chronic effect: of enclosulfan on the testiculalfi~nctions of rat :lillt: 'To lind out Llic toxic vlicct of endoililiu~ ol! Ulc tusuc~~lnr ionctiw~ 01 puknill rrb. MilJloti~m\j~ns. I~esu11s: In ~rldt)s~~liiu~.lwaI~tl ;:it&, UICW WR. n IV~UC~~OII ill LhC lWdy wig111 und tlr \wi@~ts ui Ic\ti\lia ;~nd:tccu:.u,ry rcr urgrns, a rl?. CIUW in lllc I~~IICUIU i~~ulc and pymvillc wtivitiu, u;d ut d~c lt~liculitr DNA m~d IINA C~III~.CIIIT.I~~O~I\I i~hc~a\ ih~ ~L.SUCU~Y pmuUI CO~CC~LTJUO~ was slighlly i t m d ; dw spsific xliviiy of leslicu!iu ~t~~iduglnif CIIBIIIC, :i$-Otis~ciuid &hyJ~c)gL?n.m ad IIC iluorbic cad level WPC decrciaul, wllich wlr corrtlated wih a dwrcsc in rtciuidoge- ~tcsis. 1 1 lywucu~ul ~ emynu? ncid phosplwtw rind brwh-LmrJcr cuyntc nlhlillins pho~phnww ~cliviriu wotr; also Jcc:cwd in rhc tcrtis of uwtcd mu. Conclusion: In puberl;ii mLs, endosullm (rca.mtt inl~ibik !he wticukd fu~icttuns. (Ailinr~ J Arulru! 1YB Dec; 1 : ?a3 - 206) llrm is gro\vutg couccnt lhxt cn!'iroilll~rni;ll clii,llli. cJr. tdh n~lurdl md IIUII-ntnde, h?vi!lg csux-gmic propeny #nay he ~iusii~g n vvicty of rcpmluctive disor- 4rs in u,ildlifc d IIWMI ~~plaliUIUj. Most of the rl;s~~iicd~. \vl;icll u.4 a p-sticides ;ul: noi !tifill) rlccti\%-, but av gcirdly toxic lo ltlimj tloll-lwgcl spies, incluili$ tnnn &ad oo(her winds. Endosulfm, ;u~ inusucidc ol cyclcdiur group is cxluwivcly urul irq UI in..;ricide ntdnly in ~g~iculm and in some cpunlricr ii~ public 114d1['~. Ar a ruulr of ik wide s p d luc, it rial lr a p~sntid cnvimtd unlill~u~uif ud may mmlu: a pUic lu.dlh l*wrd('l. hKbPulf;m 11s b t l ----- Cura&lrr to I*. P. P. hlYlur c.nml: ~plulluOydrn.mnn '1~1: +91.41:4.
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FUNCTIONAL STUDIES ON THE EFFECTS O
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ACKNOWLEDGEMENTS I wish to express
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TABLE OF CONTENTS Page No ACKNOWLED
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TABLE OF CONTENTS (Continued) Deter
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TABLE OF CONTENTS (Continued) Effec
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TAULIC OF CON'I'ISN'I'S (C'untinued
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xi LIST OF TABLES (Continued) I'agc
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Table 24a Table 24b Table 24c Table
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Fig. 1 Fig. 2 Effect of TCDD on the
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Fig. 12c Fig. 12d Fig. 13 Fig. 14a
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LIST OF FIGURES (Continued) Fig. 23
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LH M PL mg mRNA N AD NADH NADP NADP
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layers, an outer layer of visceral
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tubular epithelium and continually
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lmn~unization of monkeys against FS
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and this reaction is catalyzed by t
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extratubular environment or synthes
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the most active in protein secretio
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1958). A rapid fall in serum testos
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have also been reported in the rats
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Effect of TCDD on heart muscle has
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1.4 Effect of oxidative stress on m
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2 SCOPE OF THE PRESENT STUDY There
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3 MATERIALS AND METHODS 3.1 Animals
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Subgroup III: Administration of TCD
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choppcd with the help of sharp razo
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anti-FSH antibody. After incubation
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lust sped (500 to 700 rpm) on an or
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3.13.4 Quantitative determinntiun u
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The plates were dried by inverting
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centrifuged at 3,500 g for I5 min o
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3.17 Preparation of tiasue humogena
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supcrnutant was taken. Hlunk was pr
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3.21.4 Assay of glutathione peroxid
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4 RESULTS 4.1 Administration of TCD
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seminiferous tubules was found to b
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fractions of rat testis as compared
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4.1.11.1 Effect of TCDD on the prod
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4.2 Co-administration of TCDD and v
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4.2.8 Effect of co-administration o
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4.2.11.5 Effect of co-administratio
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Table I b. Effect of TCDD on the we
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Table 4. Effect of TCDD on the seru
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Table 7b. Effect of TCDD on the pro
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Table 8c. Effect of TCDD on the lev
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Table 9d. Effect of TCDD on the act
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Table 13. Effect of TCDD on the ant
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Table 15. Effect of TCDD on the lev
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Table 16c. Effcct of TCDD on the an
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Table 18a. Effect of co-administrat
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Table 21. Effect of co-administrati
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Table 24b. Effect of co-administrat
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Table 25c. Effect of co-administrat
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Table 26d. Effect of co-administrat
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Table 30. Effect of co-administrati
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Table 32. Effect of caadrninistrati
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Table 33c. Effcct of co-administrut
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5 DISCUSSION 5.1 Significance of th
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Measurement of weights of the acces
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compartment of the cells (Chainy el
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the reduction in daily sperm produc
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eported in the TCDD-treated rats (M
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lilnction is to ililcrccpt lipid pc
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in the animals administered with TC
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protective effects on serum testost
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suygcstccl that vivamin 1: conld im
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Fig.4~. ENect of TCDD or TCDD and v
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tE W d In w it I I (,OCX) 3s PUB (,
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Fig. 7c. Effect of TCDD or TCDD and
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u 3 f ~ = m w * N O .- ~Slew aew en
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Fig.lOb. ENmt of TCDD or TCDD and v
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Fig. 1Ir Effect of TCDD or TCDD md
Page 158 and 159: Fig. 14c. Effect of TCDD or TCDD an
Page 160 and 161: Fig. 16b. Effect of TCDD or TCDD an
Page 164 and 165: Fig.18~. EKect of TCDD or TCDD and
Page 166 and 167: 1 1.2 l4 Fig. 19b. ENect of TCDD or
Page 168 and 169: Fig. ZOb. Elkt of TCDD or TCDD and
Page 171 and 172: Fig. 21. Effect olTCDD or TCDD and
Page 173 and 174: Fig. 22c. Effect of TCDD or TCDD an
Page 175 and 176: Fig. 24b. Eflect ofTCDD or TCDD and
Page 177 and 178: 7 REFERENCES Aitken RJ, Irvine DS,
Page 179 and 180: Chitm KC, Latchoumycandanc,C, Mathu
Page 181 and 182: Flsher JS, Turner KJ, Brown D, Shar
Page 183 and 184: Hornsby PJ. Regulation of cytochrom
Page 185 and 186: Latcboumycandane C, Chitra KC, Math
Page 187 and 188: Moore RW, Panona JA, Bookstaff RC,
Page 189 and 190: Rommerts FFG, Cooke BA, Van Der Kem
Page 191 and 192: Slaunwhite WR, Burgett MJ. h virro
Page 193 and 194: 1.1 Preparation of dosing solution
Page 195 and 196: 1.4.6 Wash concentrate One bottle,
Page 197 and 198: 1.7.3 Estradiol controls Two vials.
Page 199 and 200: 1.1 1.2 Orcinol(6%) 6 g of orcinol
Page 201 and 202: 1.16.2 Horseradish peroxidase (8 Un
Page 203 and 204: 1.20 Superoxide dismutase 1.20.1 Tr
Page 205: 1.24.2 Thiobarbituric acid (TBA; 0.
Page 209: enbw1h1.W mu IUY Wcab unpiliml~t at
Page 212 and 213: cbniuis 11~11 b"nci:~lc ~wlive oxyg
Page 214 and 215: DNA, RNA ;uxl Wcin wcrr abarval, wh
Page 216 and 217: Mt~~m(10-lZsu&)vacob- Wfmn Ihehml ~
Page 218 and 219: New Delhi, llrliil Ib SCI~KK Rcm& M
Page 220 and 221: tiii~lc rcprmluction or rut (Cllitr
Page 222 and 223: wciglit (b.wt.) per day for 45 days
Page 224 and 225: 0.1 00 01 " 0.8 I . .lo Dl* rcnn IW
Page 226 and 227: Chilr:~. K.C.. L!olnn!myci!~dum. C.
Page 228 and 229: C. hteboumyeradlos . KC. CMtn . P.P
Page 230 and 231: I. 1 Ilal 01 2 1.7 # I c I ~ ~ L I
Page 232 and 233: Fin. L Corrclatwn bclwfcn "perm cou
Page 235: Iionshii nepmdvctivc mxicity ad upt
Page 240 and 241: o. Glutathione reductage mg pmWn mg
Page 242 and 243: IOWAME -. Tor. #558517 PME: 9 SESS:
Page 244 and 245: JOBNAME: Rqm. Tm. M5W7 PAOB: 11 SBS
Page 246 and 247: t 02 ELSEVIER Toricology OM) (2W1)
Page 248 and 249: ---- - wcre obtu~ncd from E-Monk. G
Page 250: 3.2. A,III~AILNI syrlo~t of ,nIroch
Page 253 and 254: Uc,#!dy. SC. N;tdcru. S , 1% Conlrb
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