ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

4.1.11.1 Effect of TCDD on the production of rcactivc oxygen spccics in the
epididymal sperm
Administration of TCDD caused a significant increase in the production of
superoxide anion nitric oxide and hydrogen peroxide in the epididymal sperm of
adult rats as compared to the corresponding groups of control animals (Table 1 1 ).
4.1.11.2 Effect of TCDD on the levels of antioxidants in the epididymal sperm
Administration of TCDD caused a significant decrease in the level of
reduced glutathione and a-tocopherol in the epididymal sperm of adult rats with
respect to the corresponding groups of control animals (Table 12).
4.1.11.3 Effect of TCDD on the antioxidant enzymes and lipid peroxidation in
the epididymal sperm
The activities of superoxide dismutase, catalase, glutathione reductase and
glutathione peroxidase decreased significantly in the epididymal sperm of the treated
animals as cornpared to the corresponding group of control animals (Table 13).
The level of lipid peroxidation increased significantly in the epididymal
sperm of treated rats as compared to the corresponding group of control animals
(Table 13).
4.1.11.4 Effect of TCDD on the production of reactive oxygen species in the
caput, corpus and cauda epididymides
Administration of TCDD caused significant increase in the production of
superoxide anion. nitric oxide and hydrogen peroxide in the caput. corpus and cauda
epididynlides of the treated rats as compared to thc corresponding groups of control
animals (Table 14).