ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

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LIST <strong>OF</strong> TABLES (Continued) Table 16b Table 16c Table 17a Table 17b Table 17c Table 18a Table 18b Table 19 Table 20 Table 21 'l'ablc 22 Table 23 Effect of TCDD on the activities of antioxidant enzymes and the level of lipid peroxidation in the corpus epididymis of adult rats Effect of TCDD on the activities of antioxidant enzymes and the level of lipid peroxidation in the cauda epididymis of adult rats Effect of TCDD on the production of superoxide anion, nitric oxide and hydrogen peroxide in the kidney of adult male rats Effect of TCDD on the levels of antioxidants in the kidney of adult male rats Effect of TCDD on the antioxidant enzymes and lipid peroxidation in the kidney of adult rats Effect of co-administration of TCDD and vitamin E on the body weight and weights of the testis, epididymis, kidney and accessory sex organs of adult male rats Effect of co-administration of TCDD and vitamin E on the body weight and weights of the testis, epididymis, kidney and accessory sex organs (per 100 g body wciyht) of adult male rats Effect of co-administration of TCDD and vitamin E on the daily sperm production, epididyrnal sperm viability, sperm motility and sperm counts in adult male rats Effect of co-administration of TCDD and vitamin E on the seminiferous tubular and lumen diameter of testis of adult male rats Effect of co-administration of TCDD and vitamin E on the serum hormone levels in adult male rats Effecl of co-adniinislration of TCDD and vitamin II on thc activities of steroidogcnic enzymes of rut [tstis Effect of co-administration of TCDD and vitamin E on the DNA, RNA and protein contents in testis of adult male rats
Table 24a Table 24b Table 24c Table 25a Table 25b Table 25c Table 26a Table 26b Table 26c Table 26d Table 27 LIST <strong>OF</strong> TABLES (Cuntinued) Page No. Effect of co-administration of TCDD and vitamin E on the production of superoxide anion in the crude homopenate. mitochondrial and microsome-rich liuclions ol' tcstis of adult rats 8 1 Effect of co-administration of TCDD and vitamin E on the production of nitric oxide in the crude homogenate, mitochondrial and microsome-rich fractions of testis of adult rats 82 Effect of co-administration of TCDD and vitamin E on the hydrogen peroxide generation in the crude homogenate, mitochondria1 and microsome-rich fractions of rat testis 82 Effect of co-administration of TCDD and vitamin E on the level of glutathione in the crude homogenate, mitochondria1 and microsome-rich fractions of rat testis 83 Effect of co-administration of TCDD and vitamin E on the level of vitamin E in the crude homogenate, mitochondrial and microsome-rich fractions of rat testis 83 Effect of co-administration of TCDD and vitamin E on the levels of ascorbic acid in the crude homogenate, mitochondrial and microsome-rich fractions of rat testis Effect of co-administration of TCDD and vitamin E on the activity of superoxide dismutase in the crude homogenate, mitochondrial and microsome-rich fractions of rat testis Effect of co-administration of TCDD and vitamin E on the activity of catalase in the crude hornogenate, mitochondrial and microsome-rich fractions of rat testis Effect of co-administration of TCDD and vitamin E on thc activity of glutathione reductase in the crude homogenate. mitochondria1 and microsome-rich fractions of rat testis 85 Effect of co-administration of TCDD and vitamin E on the activity of glutathione peroxidase in the crude homogenate, mitochondria1 and microsome-rich fractions of rat testis 86 Effect of co-administration of TCDD and vitamin E on the level of lipid peroxidation in the crude homoyenatc. mitochondria1 and microsome-rich fractions of rat testis 86
Page 1 and 2: FUNCTIONAL STUDIES ON THE EFFECTS O
Page 3 and 4: ACKNOWLEDGEMENTS I wish to express
Page 5 and 6: TABLE OF CONTENTS Page No ACKNOWLED
Page 7 and 8: TABLE OF CONTENTS (Continued) Deter
Page 9 and 10: TABLE OF CONTENTS (Continued) Effec
Page 11 and 12: TAULIC OF CON'I'ISN'I'S (C'untinued
Page 13: xi LIST OF TABLES (Continued) I'agc
Page 17 and 18: Fig. 1 Fig. 2 Effect of TCDD on the
Page 19 and 20: Fig. 12c Fig. 12d Fig. 13 Fig. 14a
Page 21 and 22: LIST OF FIGURES (Continued) Fig. 23
Page 23 and 24: LH M PL mg mRNA N AD NADH NADP NADP
Page 25 and 26: layers, an outer layer of visceral
Page 27 and 28: tubular epithelium and continually
Page 29 and 30: lmn~unization of monkeys against FS
Page 31 and 32: and this reaction is catalyzed by t
Page 33 and 34: extratubular environment or synthes
Page 35 and 36: the most active in protein secretio
Page 37 and 38: 1958). A rapid fall in serum testos
Page 39 and 40: have also been reported in the rats
Page 41 and 42: Effect of TCDD on heart muscle has
Page 43 and 44: 1.4 Effect of oxidative stress on m
Page 45 and 46: 2 SCOPE OF THE PRESENT STUDY There
Page 47 and 48: 3 MATERIALS AND METHODS 3.1 Animals
Page 49 and 50: Subgroup III: Administration of TCD
Page 51 and 52: choppcd with the help of sharp razo
Page 53 and 54: anti-FSH antibody. After incubation
Page 55 and 56: lust sped (500 to 700 rpm) on an or
Page 57 and 58: 3.13.4 Quantitative determinntiun u
Page 59 and 60: The plates were dried by inverting
Page 61 and 62: centrifuged at 3,500 g for I5 min o
Page 63 and 64: 3.17 Preparation of tiasue humogena
Page 65 and 66:
supcrnutant was taken. Hlunk was pr
Page 67 and 68:
3.21.4 Assay of glutathione peroxid
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4 RESULTS 4.1 Administration of TCD
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seminiferous tubules was found to b
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fractions of rat testis as compared
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4.1.11.1 Effect of TCDD on the prod
Page 78 and 79:
4.2 Co-administration of TCDD and v
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4.2.8 Effect of co-administration o
Page 82 and 83:
4.2.11.5 Effect of co-administratio
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Table I b. Effect of TCDD on the we
Page 86 and 87:
Table 4. Effect of TCDD on the seru
Page 88 and 89:
Table 7b. Effect of TCDD on the pro
Page 90 and 91:
Table 8c. Effect of TCDD on the lev
Page 92 and 93:
Table 9d. Effect of TCDD on the act
Page 94 and 95:
Table 13. Effect of TCDD on the ant
Page 96 and 97:
Table 15. Effect of TCDD on the lev
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Table 16c. Effcct of TCDD on the an
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Table 18a. Effect of co-administrat
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Table 21. Effect of co-administrati
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Table 24b. Effect of co-administrat
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Table 25c. Effect of co-administrat
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Table 26d. Effect of co-administrat
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Table 30. Effect of co-administrati
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Table 32. Effect of caadrninistrati
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Table 33c. Effcct of co-administrut
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5 DISCUSSION 5.1 Significance of th
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Measurement of weights of the acces
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compartment of the cells (Chainy el
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the reduction in daily sperm produc
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eported in the TCDD-treated rats (M
Page 127 and 128:
lilnction is to ililcrccpt lipid pc
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in the animals administered with TC
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protective effects on serum testost
Page 133:
suygcstccl that vivamin 1: conld im
Page 136 and 137:
Fig.4~. ENect of TCDD or TCDD and v
Page 138:
tE W d In w it I I (,OCX) 3s PUB (,
Page 142 and 143:
Fig. 7c. Effect of TCDD or TCDD and
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u 3 f ~ = m w * N O .- ~Slew aew en
Page 147 and 148:
Fig.lOb. ENmt of TCDD or TCDD and v
Page 151:
Fig. 1Ir Effect of TCDD or TCDD md
Page 158 and 159:
Fig. 14c. Effect of TCDD or TCDD an
Page 160 and 161:
Fig. 16b. Effect of TCDD or TCDD an
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Fig.18~. EKect of TCDD or TCDD and
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1 1.2 l4 Fig. 19b. ENect of TCDD or
Page 168 and 169:
Fig. ZOb. Elkt of TCDD or TCDD and
Page 171 and 172:
Fig. 21. Effect olTCDD or TCDD and
Page 173 and 174:
Fig. 22c. Effect of TCDD or TCDD an
Page 175 and 176:
Fig. 24b. Eflect ofTCDD or TCDD and
Page 177 and 178:
7 REFERENCES Aitken RJ, Irvine DS,
Page 179 and 180:
Chitm KC, Latchoumycandanc,C, Mathu
Page 181 and 182:
Flsher JS, Turner KJ, Brown D, Shar
Page 183 and 184:
Hornsby PJ. Regulation of cytochrom
Page 185 and 186:
Latcboumycandane C, Chitra KC, Math
Page 187 and 188:
Moore RW, Panona JA, Bookstaff RC,
Page 189 and 190:
Rommerts FFG, Cooke BA, Van Der Kem
Page 191 and 192:
Slaunwhite WR, Burgett MJ. h virro
Page 193 and 194:
1.1 Preparation of dosing solution
Page 195 and 196:
1.4.6 Wash concentrate One bottle,
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1.7.3 Estradiol controls Two vials.
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1.1 1.2 Orcinol(6%) 6 g of orcinol
Page 201 and 202:
1.16.2 Horseradish peroxidase (8 Un
Page 203 and 204:
1.20 Superoxide dismutase 1.20.1 Tr
Page 205 and 206:
1.24.2 Thiobarbituric acid (TBA; 0.
Page 207 and 208:
Chronic effect: of enclosulfan on t
Page 209:
enbw1h1.W mu IUY Wcab unpiliml~t at
Page 212 and 213:
cbniuis 11~11 b"nci:~lc ~wlive oxyg
Page 214 and 215:
DNA, RNA ;uxl Wcin wcrr abarval, wh
Page 216 and 217:
Mt~~m(10-lZsu&)vacob- Wfmn Ihehml ~
Page 218 and 219:
New Delhi, llrliil Ib SCI~KK Rcm& M
Page 220 and 221:
tiii~lc rcprmluction or rut (Cllitr
Page 222 and 223:
wciglit (b.wt.) per day for 45 days
Page 224 and 225:
0.1 00 01 " 0.8 I . .lo Dl* rcnn IW
Page 226 and 227:
Chilr:~. K.C.. L!olnn!myci!~dum. C.
Page 228 and 229:
C. hteboumyeradlos . KC. CMtn . P.P
Page 230 and 231:
I. 1 Ilal 01 2 1.7 # I c I ~ ~ L I
Page 232 and 233:
Fin. L Corrclatwn bclwfcn "perm cou
Page 235:
Iionshii nepmdvctivc mxicity ad upt
Page 240 and 241:
o. Glutathione reductage mg pmWn mg
Page 242 and 243:
IOWAME -. Tor. #558517 PME: 9 SESS:
Page 244 and 245:
JOBNAME: Rqm. Tm. M5W7 PAOB: 11 SBS
Page 246 and 247:
t 02 ELSEVIER Toricology OM) (2W1)
Page 248 and 249:
---- - wcre obtu~ncd from E-Monk. G
Page 250:
3.2. A,III~AILNI syrlo~t of ,nIroch
Page 253 and 254:
Uc,#!dy. SC. N;tdcru. S , 1% Conlrb
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